Human GPNMB Recombinant Protein – Cat# MBS146152

Glycoprotein Nmb (GPNMB) Human Recombinant Protein

Name: GPNMB Recombinant Protein; Glycoprotein Nmb; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146152
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146152

Description: GPNMB Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 476 amino acids (22-474) and having a molecular mass of 53.2 kDa.GPNMB is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Glycoprotein Nmb (GPNMB), Recombinant Protein

Full Product Name

Recombinant Human Glycoprotein Nmb

Product Gene Name

GPNMB recombinant protein

Product Synonym Names

GPNMB Human; Glycoprotein Nmb Human Recombinant; Transmembrane glycoprotein NMB; Transmembrane glycoprotein HGFIN; GPNMB; HGFIN; NMB; Glycoprotein (transmembrane) nmb

Sequence

MGSSHHH HHH SSGLVPRGSH MGSAKR FHDV LGNERPSAYM REHNQLNGWS SDENDWNEKL YPVWKRGDMR WKNSWKGGRV QAVLTSDSPA LVGSNITFAV NLIFPRCQKE DANGNIVYEK NCRNEAGLSA DPYVYNWTAW SEDSDGENGT GQSHHNVFPD GKPFPHHPGW RRWNFIYVFH TLGQYFQKLG RCSVRVSVNT ANVTLGPQLM EVTVYRRHGR AYVPIAQVKD VYVVTDQIPV FVTMFQKNDR NSSDETFLKD LPIMFDVLIH DPSHFLNYST INYKWSFGDN TGLFVSTNHT VNHTYVLNGT FSLNLTVKAA APGPCPPPPP PPRPSKPTPS LGPAGDNPLE LSRIPDENCQ INRYGHFQAT ITIVEGILEV NIIQMTDVLM PVPWPESSLI DFVVTCQGSI PTEVCTIISD PTCEITQNTV CSPVDVDEMC LLTVRRTFNG SGTYCVNLTL GDDTSLALTS TLISVP.

Host

E Coli

Form/Format

The GPNMB solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 85.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Molecular Weight

62,643 Da

OMIM

604368

3D Structure

ModBase 3D Structure for Q14956

Product Categories/Family for GPNMB recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of GPNMB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GPNMB purchase

MBS146152 is a recombinant protein targeting GPNMB. Also known as Recombinant Human Glycoprotein Nmb. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GPNMB. It may not necessarily be applicable to this product.

NCBI GI #

52694752

NCBI GeneID

10457

NCBI Accession #

NP_001005340.1

UniProt Primary Accession #

Q14956

UniProt Secondary Accession #

Q6UVX1; Q8N1A1; A4D155

UniProt Related Accession #

Q14956

GenBank Nucleotide #

NM_001005340.1

NCBI Official Full Name

transmembrane glycoprotein NMB isoform a

NCBI Official Synonym Full Names

glycoprotein (transmembrane) nmb

NCBI Official Symbol

GPNMB

NCBI Official Synonym Symbols

NMB; HGFIN

UniProt Protein Name

Transmembrane glycoprotein NMB

UniProt Synonym Protein Names

Transmembrane glycoprotein HGFIN

Protein Family

Transmembrane glycoprotein

UniProt Gene Name

GPNMB

UniProt Synonym Gene Names

HGFIN; NMB

UniProt Entry Name

GPNMB_HUMAN

NCBI Protein Information

transmembrane glycoprotein NMB; glycoprotein nmb-like protein; osteoactivin; transmembrane glycoprotein HGFIN

NCBI Summary for GPNMB

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for GPNMB

GPNMB: Could be a melanogenic enzyme. Belongs to the PMEL/NMB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 7p15

Cellular Component: integral to plasma membrane; integral to membrane; melanosome

Molecular Function: integrin binding; heparin binding

Biological Process: osteoblast differentiation; negative regulation of cell proliferation; cell adhesion; bone mineralization

Research Articles on GPNMB

1. DC-HIL+ CD14+ HLA-DR no/low cells are a potential blood marker and therapeutic target for melanoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GPNMB recombinant protein

Reference Product	PubMed Publications
TYRP1 recombinant protein	>14 publications with GPNMB and TYRP1
FLCN recombinant protein	>2 publications with GPNMB and FLCN
TREM2 recombinant protein	>1 publications with GPNMB and TREM2
TFE3 recombinant protein	>1 publications with GPNMB and TFE3

Diseases associated with GPNMB recombinant protein

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>18 publications with GPNMB and Disease Models, Animal
Inflammation Antibodies	>17 publications with GPNMB and Inflammation
Breast Neoplasms Antibodies	>11 publications with GPNMB and Breast Neoplasms
Kidney Diseases Antibodies	>10 publications with GPNMB and Kidney Diseases
Liver Diseases Antibodies	>10 publications with GPNMB and Liver Diseases
Fibrosis Antibodies	>6 publications with GPNMB and Fibrosis
Neoplasms, Experimental Antibodies	>6 publications with GPNMB and Neoplasms, Experimental
Cardiovascular Diseases Antibodies	>5 publications with GPNMB and Cardiovascular Diseases
Hypertension Antibodies	>5 publications with GPNMB and Hypertension
Necrosis Antibodies	>4 publications with GPNMB and Necrosis

Organs/Tissues associated with GPNMB recombinant protein

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>53 publications with GPNMB and Eye
Blood Antibodies	>42 publications with GPNMB and Blood
Bone Antibodies	>32 publications with GPNMB and Bone
Kidney Antibodies	>15 publications with GPNMB and Kidney
Nerve Antibodies	>15 publications with GPNMB and Nerve
Brain Antibodies	>15 publications with GPNMB and Brain
Liver Antibodies	>13 publications with GPNMB and Liver
Skin Antibodies	>11 publications with GPNMB and Skin
Muscle Antibodies	>10 publications with GPNMB and Muscle
Lung Antibodies	>8 publications with GPNMB and Lung