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LIM Domain Only 1 (LMO1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146154

Description: LMO1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids (1-156 a.a) and having a molecular mass of 20.2kDa.LMO1 is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
LIM Domain Only 1 (LMO1), Recombinant Protein
Full Product Name
Recombinant Human LIM Domain Only 1
Product Gene Name
Product Synonym Names
LMO1 Human; LIM Domain Only 1 Human Recombinant; Rhombotin-1; Cysteine-rich protein TTG-1; LIM domain only protein 1; T-cell translocation protein 1; RBTN1; RHOM1; TTG1; LMO-1; LMO1
Sequence
MGSSHHH HHH SSGLVPRGSH MGSMMV LDKE DGVPMLSVQP KGKQKGCAGC NRKIKDRYLL KALDKYWHED CLKCACCDCR LGEVGSTLYT KANLILCRRD YLRLFGTTGN CAACSKLIPA FEMVMRARDN VYHLDCFACQ LCNQRFCVGD KFFLKNNMIL CQMDYEEGQL NGTFESQVQ< /u>
Host
E Coli
Form/Format
Sterile Filtered colorless solution.
Purity/Purification
Greater than 85.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Molecular Weight
17,697 Da
OMIM
186921
3D Structure
ModBase 3D Structure for P25800

Other Notes

Small volumes of LMO1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LMO1 purchase

MBS146154 is a recombinant protein targeting LMO1. Also known as Recombinant Human LIM Domain Only 1. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for LMO1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
rhombotin-1 isoform b
NCBI Official Synonym Full Names
LIM domain only 1 (rhombotin 1)
NCBI Official Symbol
LMO1
NCBI Official Synonym Symbols
TTG1; RBTN1; RHOM1
UniProt Protein Name
Rhombotin-1
UniProt Synonym Protein Names
Cysteine-rich protein TTG-1; LIM domain only protein 1; LMO-1; T-cell translocation protein 1
Protein Family
UniProt Gene Name
LMO1
UniProt Synonym Gene Names
RBTN1; RHOM1; TTG1; LMO-1
UniProt Entry Name
RBTN1_HUMAN
NCBI Protein Information
rhombotin-1; LIM domain only protein 1; LMO-1; T-cell translocation gene 1; T-cell translocation protein 1; cysteine-rich protein TTG-1

NCBI Summary for LMO1

This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]
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UniProt Comments for LMO1

LMO1: May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.

Protein type: Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: nucleus

Molecular Function: zinc ion binding

Biological Process: positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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