Human NRTN Active Protein – Cat# MBS146161

Neurturin (NRTN) Human Active Protein

Name: NRTN Active Protein; Neurturin; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146161
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146161

Description: NRTN Human Recombinant produced in E Coli is a homodimeric non-glycosylated polypeptide chains consisting of two 102 amino acids and having a molecular mass of 23.4kDa. Introduction: NRTN belongs to the GDNF family of ligands, a distant member of… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Neurturin (NRTN), Active Protein

Full Product Name

Recombinant Human Neurturin

Product Gene Name

NRTN active protein

Product Synonym Names

NRTN Human; Neurturin Human Recombinant; Neurturin

Sequence

ARLGARPCGL RELEVRVSEL GLGYASDETV LFRYCAGACE AAARVYDLGL RRLRQRRRLR RERVRAQPCC RPTAYEDEVS FLDAHSRYHT VHELSARECA CV

Host

E Coli

Form/Format

NRTN protein was lyophilized from a 0.2 um filtered concentrated solution in 30 mM Citrate Sodium, pH 4.2, 400 mM NaCl, with 0.02 % Tween-20.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 96.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized NRTN although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution NRTN should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Molecular Weight

22,405 Da

OMIM

602018

3D Structure

ModBase 3D Structure for Q99748

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized NRTN in sterile 18M?-cm H2O not less than 0.5mg/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

Fully biologically active when compared to standard. The biologically active as determined by its binding ability in a functional ELISA.

Product Categories/Family for NRTN active protein

Cytokines and Growth Factors; Neurotrophins

Other Notes

Small volumes of NRTN active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NRTN purchase

MBS146161 is an active protein targeting NRTN. Also known as Recombinant Human Neurturin. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NRTN. It may not necessarily be applicable to this product.

NCBI GI #

4758826

NCBI GeneID

4902

NCBI Accession #

NP_004549.1

UniProt Primary Accession #

Q99748

UniProt Secondary Accession #

B2RPE8

UniProt Related Accession #

Q99748

GenBank Nucleotide #

NM_004558.3

NCBI Official Full Name

neurturin preproprotein

NCBI Official Synonym Full Names

neurturin

NCBI Official Symbol

NRTN

NCBI Official Synonym Symbols

NTN

UniProt Protein Name

Neurturin

Protein Family

Neurturin

UniProt Gene Name

NRTN

UniProt Entry Name

NRTN_HUMAN

NCBI Protein Information

neurturin; prepro-neurturin

NCBI Summary for NRTN

Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Jul 2008]

UniProt Comments for NRTN

NRTN: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Belongs to the TGF-beta family. GDNF subfamily.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: axon; extracellular region

Molecular Function: growth factor activity; receptor binding

Biological Process: nervous system development; axon guidance; MAPKKK cascade; nerve development; neural crest cell migration; neurite development; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Hirschsprung Disease, Susceptibility To, 1

Research Articles on NRTN

1. In the cochlea, NTN immunostaining was found in the supporting cells of organ of Corti, including Deiters' cells, Hensen cells as well as Claudius' cells. In the spiral ganglia, NTN was seen in both the cell bodies and the nerve fibers of neurons.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NRTN active protein

Reference Product	PubMed Publications
GDNF active protein	>145 publications with NRTN and GDNF
RET active protein	>109 publications with NRTN and RET
GFRA2 active protein	>43 publications with NRTN and GFRA2
GFRA1 active protein	>36 publications with NRTN and GFRA1
ARTN active protein	>22 publications with NRTN and ARTN
PSPN active protein	>11 publications with NRTN and PSPN
GFRA3 active protein	>7 publications with NRTN and GFRA3
NCAM1 active protein	>4 publications with NRTN and NCAM1

Pathways associated with NRTN active protein

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
NCAM Signaling For Neurite Out-growth Pathway antibodies	NCAM Signaling For Neurite Out-growth Pathway Diagram
NCAM1 Interactions Pathway antibodies	NCAM1 Interactions Pathway Diagram

Diseases associated with NRTN active protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>29 publications with NRTN and Nervous System Diseases
Nerve Degeneration Antibodies	>23 publications with NRTN and Nerve Degeneration
Congenital Abnormalities Antibodies	>8 publications with NRTN and Congenital Abnormalities
Hirschsprung Disease Antibodies	>8 publications with NRTN and Hirschsprung Disease
Inflammation Antibodies	>5 publications with NRTN and Inflammation
Weight Loss Antibodies	>3 publications with NRTN and Weight Loss
Necrosis Antibodies	>2 publications with NRTN and Necrosis
Hypertrophy Antibodies	>2 publications with NRTN and Hypertrophy
Fetal Death Antibodies	>2 publications with NRTN and Fetal Death
Kidney Neoplasms Antibodies	>2 publications with NRTN and Kidney Neoplasms

Organs/Tissues associated with NRTN active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>67 publications with NRTN and Brain
Eye Antibodies	>17 publications with NRTN and Eye
Muscle Antibodies	>14 publications with NRTN and Muscle
Intestine Antibodies	>14 publications with NRTN and Intestine
Pancreas Antibodies	>3 publications with NRTN and Pancreas
Lung Antibodies	>1 publications with NRTN and Lung