Human MPZL1 Recombinant Protein – Cat# MBS146168

Myelin Protein Zero-Like 1 (MPZL1) Human Recombinant Protein

Name: MPZL1 Recombinant Protein; Myelin Protein Zero-Like 1; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146168
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146168

Description: MPZL1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 148 amino acids (38-162) and having a molecular mass of 16.1kDa.MPZL1 is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Myelin Protein Zero-Like 1 (MPZL1), Recombinant Protein

Full Product Name

Recombinant Human Myelin Protein Zero-Like 1

Product Gene Name

MPZL1 recombinant protein

Product Synonym Names

MPZL1 Human; Myelin Protein Zero-Like 1 Human Recombinant; Myelin Protein Zero-Like 1; PZRa; PZR; Protein Zero-Related; PZRb; Immunoglobulin Family Transmembrane Protein; Myelin Protein Zero-Like Protein 1; MPZL1b; Protein Zero Related; PZR1b

Sequence

MGSSHHH HHH SSGLVPRGSH MGSLEV YTPK EIFVANGTQG KLTCKFKSTS TTGGLTSVSW SFQPEGADTT VSFFHYSQGQ VYLGNYPPFK DRISWAGDLD KKDASINIEN MQFIHNGTYI CDVKNPPDIV VQPGHIRLYV VEKENLPV.& nbsp;

Host

E Coli

Form/Format

The MPZL1 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 20% glycerol.
Sterile filtered colorless solution.

Purity/Purification

Greater than 90% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Molecular Weight

12,354 Da

OMIM

604376

3D Structure

ModBase 3D Structure for O95297

Product Categories/Family for MPZL1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Myelin Oligodendrocyte Glycoprotein

Other Notes

Small volumes of MPZL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MPZL1 purchase

MBS146168 is a recombinant protein targeting MPZL1. Also known as Recombinant Human Myelin Protein Zero-Like 1. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MPZL1. It may not necessarily be applicable to this product.

NCBI GI #

226054871

NCBI GeneID

9019

NCBI Accession #

NP_001139663.1

UniProt Primary Accession #

O95297

UniProt Secondary Accession #

Q5R332; Q8IX11; Q9BWZ3; Q9NYK4; Q9UL20; B2REB9; B2REC0

UniProt Related Accession #

O95297

GenBank Nucleotide #

NM_001146191.1

NCBI Official Full Name

myelin protein zero-like protein 1 isoform c

NCBI Official Synonym Full Names

myelin protein zero-like 1

NCBI Official Symbol

MPZL1

NCBI Official Synonym Symbols

PZR; PZRa; PZRb; PZR1b; MPZL1b

UniProt Protein Name

Myelin protein zero-like protein 1

UniProt Synonym Protein Names

Protein zero-related

Protein Family

Myelin protein zero-like protein

UniProt Gene Name

MPZL1

UniProt Synonym Gene Names

PZR

UniProt Entry Name

MPZL1_HUMAN

NCBI Protein Information

myelin protein zero-like protein 1; immunoglobulin family transmembrane protein; protein zero related; protein zero-related

UniProt Comments for MPZL1

PZR: an immunoglobulin superfamily cell surface protein. Contains two tyrosine-based inhibition motifs (ITIMs) responsible for binding of SHP-2. When phosphorylated, it can specifically bind SHP-2, blocking its translocation, and interupting its function. Treatment of several cell lines with ConA caused tyrosine phosphorylation of PZR. Two alternatively spliced isoforms have been reported. One isoform, PZR1b, lacks the ITIMs and has a dominant negative effect upon full-length PZR and its recruitment of SHP-2.

Protein type: Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q24.2

Cellular Component: focal adhesion; cell surface; integral to plasma membrane

Molecular Function: protein binding; structural molecule activity

Biological Process: cell-cell signaling; transmembrane receptor protein tyrosine kinase signaling pathway

Research Articles on MPZL1

1. MPZL1 is a target gene within the 1q24.1-24.2 amplicon that plays a pivotal role in HCC cell migration and tumor metastasis, and a novel MPZL1/Src/cortactin signaling cascade.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MPZL1 recombinant protein

Reference Product	PubMed Publications
SRC recombinant protein	>5 publications with MPZL1 and SRC
PTPN11 recombinant protein	>5 publications with MPZL1 and PTPN11
PTPN6 recombinant protein	>2 publications with MPZL1 and PTPN6

Pathways associated with MPZL1 recombinant protein

Products by Pathway	Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram

Diseases associated with MPZL1 recombinant protein

Disease Name	Pubmed Publications
Carcinoma, Hepatocellular Antibodies	>2 publications with MPZL1 and Carcinoma, Hepatocellular
Carcinoma Antibodies	>2 publications with MPZL1 and Carcinoma
Lung Neoplasms Antibodies	>1 publications with MPZL1 and Lung Neoplasms
Lung Diseases Antibodies	>1 publications with MPZL1 and Lung Diseases
Edema Antibodies	>1 publications with MPZL1 and Edema
Atrophy Antibodies	>1 publications with MPZL1 and Atrophy
Disease Models, Animal Antibodies	>1 publications with MPZL1 and Disease Models, Animal
Liver Diseases Antibodies	>1 publications with MPZL1 and Liver Diseases
Liver Neoplasms Antibodies	>1 publications with MPZL1 and Liver Neoplasms
Adenocarcinoma Antibodies	>1 publications with MPZL1 and Adenocarcinoma

Organs/Tissues associated with MPZL1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>3 publications with MPZL1 and Nerve
Blood Antibodies	>2 publications with MPZL1 and Blood
Embryonic Tissue Antibodies	>2 publications with MPZL1 and Embryonic Tissue
Muscle Antibodies	>2 publications with MPZL1 and Muscle
Liver Antibodies	>1 publications with MPZL1 and Liver
Kidney Antibodies	>1 publications with MPZL1 and Kidney
Eye Antibodies	>1 publications with MPZL1 and Eye
Vascular Antibodies	>1 publications with MPZL1 and Vascular
Pancreas Antibodies	>1 publications with MPZL1 and Pancreas
Placenta Antibodies	>1 publications with MPZL1 and Placenta