Human SFRP4 Recombinant Protein – Cat# MBS146172

Secreted Frizzled-Related Protein 4 (SFRP4) Human Recombinant Protein

Name: SFRP4 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146172
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146172

Description: SFRP4 Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (a.a 19-346) containing a total of 341 amino acids, having a molecular mass of 39kDa (calculated), though it migrates at approximately 55kDa on SDS PAGE,… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Secreted Frizzled-Related Protein 4 (SFRP4), Recombinant Protein

Full Product Name

Recombinant Human Secreted Frizzled-Related Protein 4

Product Gene Name

SFRP4 recombinant protein

Product Synonym Names

SFRP4 Human; Secreted Frizzled-Related Protein 4 Human Recombinant; Secreted frizzled-related protein 4; sFRP-4; Frizzled protein; human endometrium; FrpHE; SFRP4; FRPHE; FRP-4

Sequence

PGDYKDD DDK PAGVRG APCE AVRIPMCRHM PWNITRMPNH LHHSTQENAI LAIEQYEELV DVNCSAVLRF FLCAMYAPIC TLEFLHDPIK PCKSVCQRAR DDCEPLMKMY NHSWPESLAC DELPVYDRGV CISPEAIVTD LPEDVKWIDI TPDMMVQERP LDVDCKRLSP DRCKCKKVKP TLATYLSKNY SYVIHAKIKA VQRSGCNEVT TVVDVKEIFK SSSPIPRTQV PLITNSSCQC PHILPHQDVL IMCYEWRSRM MLLENCLVEK WRDQLSKRSI QWEERLQEQR RTVQDKKKTA GRTSRSNPPK PKGKPPAPKP ASPKKNIKTR SAQKRTNPKR V.

Host

HEK 293

Form/Format

Filtered (0.4 um) and lyophilized from 0.5mg/ml in 0.05M phosphate buffer and 0.075M NaCl, pH 7.4.
Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Purity as determined by densitometric image analysis is greater than 90%.

Preparation and Storage

Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.

Molecular Weight

39,827 Da

OMIM

606570

3D Structure

ModBase 3D Structure for Q6FHJ7

Solubility

It is recommended to add 200 ul deionized water to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely. SFRP4 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

Product Categories/Family for SFRP4 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of SFRP4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SFRP4 purchase

MBS146172 is a recombinant protein targeting SFRP4. Also known as Recombinant Human Secreted Frizzled-Related Protein 4. Host: HEK 293.

Additional Details

NCBI/Uniprot data below describe general gene information for SFRP4. It may not necessarily be applicable to this product.

NCBI GI #

170784838

NCBI GeneID

6424

NCBI Accession #

NP_003005.2

UniProt Primary Accession #

Q6FHJ7

UniProt Secondary Accession #

O14877; Q05BG7; Q1ZYW2; Q4G124; Q6FHM0; Q6PD64; B4DYC1

UniProt Related Accession #

Q6FHJ7

GenBank Nucleotide #

NM_003014.3

NCBI Official Full Name

secreted frizzled-related protein 4

NCBI Official Synonym Full Names

secreted frizzled-related protein 4

NCBI Official Symbol

SFRP4

NCBI Official Synonym Symbols

FRP-4; FRPHE; sFRP-4

UniProt Protein Name

Secreted frizzled-related protein 4

UniProt Synonym Protein Names

Frizzled protein, human endometrium; FrpHE

Protein Family

Secreted frizzled-related protein

UniProt Gene Name

SFRP4

UniProt Synonym Gene Names

FRPHE; sFRP-4; FrpHE

UniProt Entry Name

SFRP4_HUMAN

NCBI Protein Information

secreted frizzled-related protein 4; frizzled protein, human endometrium; secreted frizzled-related protein 4; secreted frizzled-related protein 4

NCBI Summary for SFRP4

Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]

UniProt Comments for SFRP4

SFRP4: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. Belongs to the secreted frizzled-related protein (sFRP) family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7p14.1

Cellular Component: extracellular space; cell surface; cytoplasm; integral to membrane; nucleus

Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; Wnt receptor activity; protein binding

Biological Process: negative regulation of cell proliferation; positive regulation of apoptosis; multicellular organismal development; negative regulation of transcription factor activity; positive regulation of epidermal cell differentiation; positive regulation of receptor internalization; response to hormone stimulus; phosphate ion homeostasis; cell differentiation

Research Articles on SFRP4

1. Our results suggest that the sFRP3 c.970C>G and sFRP4 c.958C>A polymorphisms may be genetic factors associated with the prevalence of osteoporosis at the femoral neck in postmenopausal Korean women.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SFRP4 recombinant protein

Reference Product	PubMed Publications
WNT5A recombinant protein	>15 publications with SFRP4 and WNT5A
WNT3A recombinant protein	>12 publications with SFRP4 and WNT3A
WNT2 recombinant protein	>7 publications with SFRP4 and WNT2
WNT7B recombinant protein	>3 publications with SFRP4 and WNT7B
WNT11 recombinant protein	>2 publications with SFRP4 and WNT11
WNT2B recombinant protein	>2 publications with SFRP4 and WNT2B
WNT10B recombinant protein	>2 publications with SFRP4 and WNT10B
WNT6 recombinant protein	>1 publications with SFRP4 and WNT6
WNT8A recombinant protein	>1 publications with SFRP4 and WNT8A

Pathways associated with SFRP4 recombinant protein

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Wnt Signaling Pathway antibodies	Wnt Signaling Pathway Diagram
Wnt Signaling Pathway antibodies	Wnt Signaling Pathway Diagram
Wnt Signaling Pathway antibodies	Wnt Signaling Pathway Diagram

Diseases associated with SFRP4 recombinant protein

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>21 publications with SFRP4 and Adenocarcinoma
Kidney Diseases Antibodies	>14 publications with SFRP4 and Kidney Diseases
Colorectal Neoplasms Antibodies	>11 publications with SFRP4 and Colorectal Neoplasms
Breast Neoplasms Antibodies	>9 publications with SFRP4 and Breast Neoplasms
Cell Transformation, Neoplastic Antibodies	>9 publications with SFRP4 and Cell Transformation, Neoplastic
Ovarian Neoplasms Antibodies	>8 publications with SFRP4 and Ovarian Neoplasms
Endometrial Neoplasms Antibodies	>8 publications with SFRP4 and Endometrial Neoplasms
Respiratory Tract Diseases Antibodies	>8 publications with SFRP4 and Respiratory Tract Diseases
Inflammation Antibodies	>7 publications with SFRP4 and Inflammation
Cardiovascular Diseases Antibodies	>6 publications with SFRP4 and Cardiovascular Diseases

Organs/Tissues associated with SFRP4 recombinant protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>41 publications with SFRP4 and Bone
Eye Antibodies	>21 publications with SFRP4 and Eye
Kidney Antibodies	>20 publications with SFRP4 and Kidney
Connective Tissue Antibodies	>15 publications with SFRP4 and Connective Tissue
Ovary Antibodies	>11 publications with SFRP4 and Ovary
Uterus Antibodies	>11 publications with SFRP4 and Uterus
Muscle Antibodies	>10 publications with SFRP4 and Muscle
Liver Antibodies	>9 publications with SFRP4 and Liver
Brain Antibodies	>8 publications with SFRP4 and Brain
Lung Antibodies	>8 publications with SFRP4 and Lung