Human ORC6 Recombinant Protein – Cat# MBS146208

Origin Recognition Complex (ORC6) Human Recombinant Protein

Name: ORC6 Recombinant Protein; Origin Recognition Complex; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146208
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146208

Description: ORC6 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 275 amino acids (1-252) and having a molecular mass of 30.5kDa.ORC6 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Origin Recognition Complex (ORC6), Recombinant Protein

Full Product Name

Recombinant Human Origin Recognition Complex, Subunit 6

Product Gene Name

ORC6 recombinant protein

Product Synonym Names

ORC6 Human; Origin Recognition Complex, Subunit 6 Human Recombinant; Origin Recognition Complex Subunit 6; Origin Recognition Complex Subunit 6 Homolog-Like (Yeast); ORC6L

Sequence

MGSSHHH HHH SSGLVPRGSH MGSMGS ELIG RLAPRLGLAE PDMLRKAEEY LRLSRVKCVG LSARTTETSS AVMCLDLAAS WMKCPLDRAY LIKLSGLNKE TYQSCLKSFE CLLGLNSNIG IRDLAVQFSC IEAVNMASKI LKSYESSLPQ TQQVDLDLSR PLFTSAALLS ACKILKLKVD KNKMVATSGV KKAIFDRLCK QLEKIGQQVD REPGDVATPP RKRKKIVVEA PAKEMEKVEE MPHKPQKDED LTQDYEEWKR KILENAASAQ KATAE

Host

E Coli

Form/Format

The ORC6 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 2mM DTT and 40% glycerol.
Sterile Filtered clear solution.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Molecular Weight

28,107 Da

OMIM

607213

3D Structure

ModBase 3D Structure for Q9Y5N6

Product Categories/Family for ORC6 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of ORC6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ORC6 purchase

MBS146208 is a recombinant protein targeting ORC6. Also known as Recombinant Human Origin Recognition Complex, Subunit 6. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for ORC6. It may not necessarily be applicable to this product.

NCBI GI #

7657427

NCBI GeneID

23594

NCBI Accession #

NP_055136.1

UniProt Primary Accession #

Q9Y5N6

UniProt Secondary Accession #

B3KN89

UniProt Related Accession #

Q9Y5N6

GenBank Nucleotide #

NM_014321.3

NCBI Official Full Name

origin recognition complex subunit 6

NCBI Official Synonym Full Names

origin recognition complex, subunit 6

NCBI Official Symbol

ORC6

NCBI Official Synonym Symbols

ORC6L

UniProt Protein Name

Origin recognition complex subunit 6

Protein Family

ORC1-type DNA replication protein

UniProt Gene Name

ORC6

UniProt Synonym Gene Names

ORC6L

UniProt Entry Name

ORC6_HUMAN

NCBI Protein Information

origin recognition complex subunit 6

NCBI Summary for ORC6

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]

UniProt Comments for ORC6

ORC6L: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4. Belongs to the ORC6 family.

Protein type: DNA replication

Chromosomal Location of Human Ortholog: 16q12

Cellular Component: nucleoplasm; membrane; plasma membrane; nuclear origin of replication recognition complex; nucleus; origin recognition complex

Molecular Function: protein binding; DNA binding

Biological Process: mitotic cell cycle; DNA replication; DNA-dependent DNA replication; G1/S transition of mitotic cell cycle

Disease: Meier-gorlin Syndrome 3

Research Articles on ORC6

1. findings show that Orc6 not only interacts with Orc1-Orc5 but also with the initiation factor Cdc6, and that Orc6 functions at different stages of the replication initiation process.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ORC6 recombinant protein

Reference Product	PubMed Publications
CDC6 recombinant protein	>23 publications with ORC6 and CDC6
CDC45 recombinant protein	>2 publications with ORC6 and CDC45
MCM5 recombinant protein	>1 publications with ORC6 and MCM5
MCM4 recombinant protein	>1 publications with ORC6 and MCM4
CDC7 recombinant protein	>1 publications with ORC6 and CDC7

Pathways associated with ORC6 recombinant protein

Products by Pathway	Pathway Diagram
Activation Of ATR In Response To Replication Stress Pathway antibodies	Activation Of ATR In Response To Replication Stress Pathway Diagram
Activation Of The Pre-replicative Complex Pathway antibodies	Activation Of The Pre-replicative Complex Pathway Diagram
Assembly Of The ORC Complex At The Origin Of Replication Pathway antibodies	Assembly Of The ORC Complex At The Origin Of Replication Pathway Diagram
Assembly Of The Pre-replicative Complex Pathway antibodies	Assembly Of The Pre-replicative Complex Pathway Diagram
CDC6 Association With The ORC:origin Complex Pathway antibodies	CDC6 Association With The ORC:origin Complex Pathway Diagram
CDT1 Association With The CDC6:ORC:origin Complex Pathway antibodies	CDT1 Association With The CDC6:ORC:origin Complex Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Checkpoints Pathway antibodies	Cell Cycle Checkpoints Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram

Diseases associated with ORC6 recombinant protein

Disease Name	Pubmed Publications
Meier-Gorlin syndrome Antibodies	>7 publications with ORC6 and Meier-Gorlin syndrome
Nervous System Diseases Antibodies	>1 publications with ORC6 and Nervous System Diseases

Organs/Tissues associated with ORC6 recombinant protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>5 publications with ORC6 and Bone
Ear Antibodies	>4 publications with ORC6 and Ear
Blood Antibodies	>1 publications with ORC6 and Blood
Muscle Antibodies	>1 publications with ORC6 and Muscle
Mouth Antibodies	>1 publications with ORC6 and Mouth