Human Bone BMP6 Recombinant Protein – Cat# MBS146213

Morphogenetic Protein-6 (BMP6) Human Bone Recombinant Protein

Name: BMP6 Recombinant Protein; Morphogenetic Protein-6; Human Bone; MyBioSource
Brand: MyBioSource
SKU: MBS146213
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146213

Description: BMP6 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 164 amino acids (375-513) and having a molecular mass of 18kDa.BMP6 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Morphogenetic protein-6 (BMP6), Recombinant Protein

Full Product Name

Recombinant Human Bone Morphogenetic protein-6

Product Gene Name

BMP6 recombinant protein

Product Synonym Names

BMP6 Human; Bone Morphogenetic protein-6 Human Recombinant; Bone morphogenetic protein 6; BMP-6; VG-1-related protein; VG-1-R; VGR-1; BMP6; VGR; VGR1

Sequence

MGSSHHH HHH SSGLVPRGSH MGSHMS ASSR RRQQSRNRST QSQDVARVSS ASDYNSSELK TACRKHELYV SFQDLGWQDW IIAPKGYAAN YCDGECSFPL NAHMNATNHA IVQTLVHLMN PEYVPKPCCA PTKLNAISVL YFDDNSNVIL KKYRNMVVRA CGCH

Host

E Coli

Form/Format

The BMP6 solution (0.25mg/ml) contains 10mM Sodium citrate buffer (pH 3.5) and 10% glycerol.
Sterile filtered colorless solution.

Purity/Purification

Greater than 85.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Molecular Weight

57,226 Da

OMIM

112266

3D Structure

ModBase 3D Structure for P22004

Product Categories/Family for BMP6 recombinant protein

Cytokines and Growth Factors; Cytokines; Bone Morphogenetic Protein

Other Notes

Small volumes of BMP6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMP6 purchase

MBS146213 is a recombinant protein targeting BMP6. Also known as Recombinant Human Bone Morphogenetic protein-6. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BMP6. It may not necessarily be applicable to this product.

NCBI GI #

4502425

NCBI GeneID

654

NCBI Accession #

NP_001709.1

UniProt Primary Accession #

P22004

UniProt Secondary Accession #

Q5TCP3

UniProt Related Accession #

P22004

GenBank Nucleotide #

NM_001718.4

NCBI Official Full Name

bone morphogenetic protein 6 preproprotein

NCBI Official Synonym Full Names

bone morphogenetic protein 6

NCBI Official Symbol

BMP6

NCBI Official Synonym Symbols

VGR; VGR1

UniProt Protein Name

Bone morphogenetic protein 6

UniProt Synonym Protein Names

VG-1-related protein; VG-1-R; VGR-1

Protein Family

Bone morphogenetic protein

UniProt Gene Name

BMP6

UniProt Synonym Gene Names

VGR; BMP-6; VG-1-R; VGR-1

UniProt Entry Name

BMP6_HUMAN

NCBI Protein Information

bone morphogenetic protein 6; BMP-6; VG-1-R; VG-1-related protein; VGR-1; Vg1-related sequence; vegetal related growth factor (TGFB-related); vegetal-related (TGFB related) cytokine

NCBI Summary for BMP6

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]

UniProt Comments for BMP6

BMP6: Induces cartilage and bone formation. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6p24-p23

Cellular Component: extracellular space; cytoplasm

Molecular Function: growth factor activity; protein heterodimerization activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: cellular iron ion homeostasis; response to glucocorticoid stimulus; BMP signaling pathway; regulation of apoptosis; response to magnesium ion; positive regulation of endothelial cell differentiation; positive regulation of aldosterone biosynthetic process; male genitalia development; kidney development; inflammatory response; skeletal development; response to iron ion; endochondral ossification; response to retinoic acid; positive regulation of bone mineralization; osteoblast differentiation; positive regulation of osteoblast differentiation; positive regulation of chondrocyte differentiation; positive regulation of protein secretion; eye development; regulation of MAPKKK cascade; cartilage development; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; response to activity; positive regulation of neuron differentiation; positive regulation of epithelial cell proliferation; growth

Research Articles on BMP6

1. Data indicated that hypermethylation modifications contributed to the regulation of BMP6 and induced an epithelial-to-mesenchymal transition phenotype of breast cancer during the acquisition of drug resistance.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BMP6 recombinant protein

Reference Product	PubMed Publications
BMPR2 recombinant protein	>59 publications with BMP6 and BMPR2
BMPR1A recombinant protein	>33 publications with BMP6 and BMPR1A
SMAD5 recombinant protein	>27 publications with BMP6 and SMAD5
BMPR1B recombinant protein	>16 publications with BMP6 and BMPR1B
ACVR2A recombinant protein	>4 publications with BMP6 and ACVR2A
NOG recombinant protein	>2 publications with BMP6 and NOG

Pathways associated with BMP6 recombinant protein

Products by Pathway	Pathway Diagram
BMP Receptor Signaling Pathway antibodies	BMP Receptor Signaling Pathway Diagram
BMP Signaling Pathway antibodies	BMP Signaling Pathway Diagram
BMP Signaling Pathway antibodies	BMP Signaling Pathway Diagram
Endochondral Ossification Pathway antibodies	Endochondral Ossification Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram
Id Signaling Pathway antibodies	Id Signaling Pathway Diagram
Ovarian Steroidogenesis Pathway antibodies	Ovarian Steroidogenesis Pathway Diagram
Ovarian Steroidogenesis Pathway antibodies	Ovarian Steroidogenesis Pathway Diagram
TGF-beta Signaling Pathway antibodies	TGF-beta Signaling Pathway Diagram

Diseases associated with BMP6 recombinant protein

Disease Name	Pubmed Publications
Anemia Antibodies	>33 publications with BMP6 and Anemia
Inflammation Antibodies	>33 publications with BMP6 and Inflammation
Disease Models, Animal Antibodies	>29 publications with BMP6 and Disease Models, Animal
Hemochromatosis Antibodies	>26 publications with BMP6 and Hemochromatosis
Liver Diseases Antibodies	>18 publications with BMP6 and Liver Diseases
Adenocarcinoma Antibodies	>17 publications with BMP6 and Adenocarcinoma
Fibrosis Antibodies	>13 publications with BMP6 and Fibrosis
Kidney Diseases Antibodies	>12 publications with BMP6 and Kidney Diseases
Necrosis Antibodies	>12 publications with BMP6 and Necrosis
Nervous System Diseases Antibodies	>11 publications with BMP6 and Nervous System Diseases

Organs/Tissues associated with BMP6 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>89 publications with BMP6 and Blood
Connective Tissue Antibodies	>45 publications with BMP6 and Connective Tissue
Ovary Antibodies	>37 publications with BMP6 and Ovary
Brain Antibodies	>32 publications with BMP6 and Brain
Embryonic Tissue Antibodies	>32 publications with BMP6 and Embryonic Tissue
Vascular Antibodies	>26 publications with BMP6 and Vascular
Prostate Antibodies	>25 publications with BMP6 and Prostate
Kidney Antibodies	>19 publications with BMP6 and Kidney
Mouth Antibodies	>13 publications with BMP6 and Mouth
Lung Antibodies	>12 publications with BMP6 and Lung