Horse hIL 1RA Active Protein – Cat# MBS146266

Interleukin-1 Receptor Antagonist (hIL 1RA) Horse Active Protein

Name: hIL 1RA Active Protein; Interleukin-1 Receptor Antagonist; Horse; MyBioSource
Brand: MyBioSource
SKU: MBS146266
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146266

Description: Recombinant Horse Interleukin-1 Receptor Antagonist produced in E Coli cells is a single, non-glycosylated, polypeptide chain containing 152 amino acids and having a molecular mass of 17.4kDa. The IL-1RA is purified by proprietary chromatographic… More details

$250 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin-1 Receptor Antagonist (hIL 1RA), Active Protein

Full Product Name

Recombinant Horse Interleukin-1 Receptor Antagonist

Product Gene Name

hIL 1RA active protein

Product Synonym Names

IL 1RA Horse; Interleukin-1 Receptor Antagonist Horse Recombinant; Interleukin-1 receptor antagonist protein; IL-1RN; IL-1ra; IRAP; IL1 inhibitor; IL1RN; IL1RA

Sequence

HPLGKRPCKM QAFRIWDVNQ KTFYMRNNQL VAGYLQESNT KLQEKIDVVP IEPDALFLGL HGRKLCLACV KSGDEIRFQL EAVNITDLSK NKEENKRFTF IRSNSGPTTS FESAACPGWF LCTAQEADRP VSLTNKPKES FMVTKFYLQE DQ.

Host

E Coli

Form/Format

The IL-1RA was lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Molecular Weight

20,460 Da

3D Structure

ModBase 3D Structure for O18999

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized IL-1RA in sterile water not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

The ED50 as determined by inhibiting IL-1alpha-dependent proliferation of murine D10.G4.1 helper T cells is less than 3.0 ug/ml, corresponding to a specific activity of > 333 IU/mg in the presence of 50 pg/ml rHuIL-1alpha.

Product Categories/Family for hIL 1RA active protein

Cytokines and Growth Factors; Cytokines; Interleukin

Other Notes

Small volumes of hIL 1RA active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for hIL 1RA purchase

MBS146266 is an active protein targeting hIL 1RA. Also known as Recombinant Horse Interleukin-1 Receptor Antagonist. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for hIL 1RA. It may not necessarily be applicable to this product.

NCBI GI #

126723134

NCBI GeneID

100034236

NCBI Accession #

NP_001075994.1

UniProt Primary Accession #

O18999

UniProt Secondary Accession #

O77745; Q9TSJ0

UniProt Related Accession #

O18999

GenBank Nucleotide #

NM_001082525.1

NCBI Official Full Name

interleukin-1 receptor antagonist protein

NCBI Official Symbol

IL1RN

NCBI Official Synonym Symbols

IL-1RA

UniProt Protein Name

Interleukin-1 receptor antagonist protein

UniProt Synonym Protein Names

IL1 inhibitor

Protein Family

Interleukin-1 receptor antagonist protein

UniProt Gene Name

IL1RN

UniProt Synonym Gene Names

IL1RA; IL-1RN; IL-1ra; IRAP

UniProt Entry Name

IL1RA_HORSE

NCBI Protein Information

interleukin-1 receptor antagonist protein; IL-1RN; IL1 inhibitor; IRAP; interleukin-1 receptor antagonist secretory form

UniProt Comments for hIL 1RA

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.

Research Articles on hIL 1RA

1. Expression of IL-1RN in the endometrium is likely regulated by estradiol and progesterone and suggest that IL-1RN regulates the degree of IL-1 signal transduction and thereby plays an important role in the establishment of equine pregnancy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with hIL 1RA active protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>778 publications with hIL 1RA and Necrosis
Inflammation Antibodies	>697 publications with hIL 1RA and Inflammation
Arthritis, Rheumatoid Antibodies	>302 publications with hIL 1RA and Arthritis, Rheumatoid
Cardiovascular Diseases Antibodies	>190 publications with hIL 1RA and Cardiovascular Diseases
Disease Models, Animal Antibodies	>165 publications with hIL 1RA and Disease Models, Animal
Skin Diseases Antibodies	>126 publications with hIL 1RA and Skin Diseases
Lung Diseases Antibodies	>111 publications with hIL 1RA and Lung Diseases
Pain Antibodies	>82 publications with hIL 1RA and Pain
Kidney Diseases Antibodies	>80 publications with hIL 1RA and Kidney Diseases
Heart Diseases Antibodies	>76 publications with hIL 1RA and Heart Diseases

Organs/Tissues associated with hIL 1RA active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1072 publications with hIL 1RA and Blood