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Core 1 Beta3-Gal-T1 (C1GALT1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146272

Description: C1GALT1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 357 amino acids (30-363 a.a) and having a molecular mass of 41.4kDa.C1GALT1 is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

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Product Overview

Online Datasheet in PDF
Product Name
Core 1 Beta3-Gal-T1 (C1GALT1), Recombinant Protein
Full Product Name
Recombinant Human Core 1 Beta3-Gal-T1
Product Gene Name
C1GALT1 recombinant protein
Product Synonym Names
C1GALT1 Human; Core 1 Beta3-Gal-T1 Human Recombinant; Core 1 Synthase; Glycoprotein-N-Acetylgalactosamine 3-Beta-Galactosyltransferase 1; Core 1 Beta3-Gal-T1; Core 1 O-Glycan T-Synthase; Core 1 UDP-Galactose:N-Acetylgalactosamine-Alpha-R Beta 1; 3 Galactosyltransferase 1; B3Gal-T8; EC 2.4.1.122; Core 1 Beta3-Gal-T; C1GALT; T-synthase; Glycoprotein-N-Acetylgalactosamine 3-Beta-Galactosyltransferase 1; Beta-1; 3-galactosyltransferase; C1GalT1; Core 1 Beta1; 3-Galactosyltransferase 1
Sequence
MGSSHHH HHH SSGLVPRGSH MGSLLG EKVD TQPNVLHNDP HARHSDDNGQ NHLEGQMNFN ADSSQHKDEN TDIAENLYQK VRILCWVMTG PQNLEKKAKH VKATWAQRCN KVLFMSSEEN KDFPAVGLKT KEGRDQLYWK TIKAFQYVHE HYLEDADWFL KADDDTYVIL DNLRWLLSKY DPEEPIYFGR RFKPYVKQGY MSGGAGYVLS KEALKRFVDA FKTDKCTHSS SIEDLALGRC MEIMNVEAGD SRDTIGKETF HPFVPEHHLI KGYLPRTFWY WNYNYYPPVE GPGCCSDLAV SFHYVDSTTM YELEYLVYHL RPYGYLYRYQ PTLPERILKE ISQANKNEDT KVKLGNP
Host
E Coli
Form/Format
C1GALT1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.
Sterile Filtered clear solution.
Purity/Purification
Greater than 80.0% as determined by SDS-PAGE.
Molecular Weight
35,935 Da
OMIM
610555
3D Structure
ModBase 3D Structure for Q9NS00

Product Categories/Family for C1GALT1 recombinant protein

Enzymes; Transferase

Other Notes

Small volumes of C1GALT1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for C1GALT1 purchase

MBS146272 is a recombinant protein targeting C1GALT1. Also known as Recombinant Human Core 1 Beta3-Gal-T1. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for C1GALT1. It may not necessarily be applicable to this product.

NCBI GI #
9910144
NCBI GeneID
56913
NCBI Accession #
NP_064541.1
UniProt Primary Accession #
Q9NS00
UniProt Secondary Accession #
Q96QH4; Q9BTU1
UniProt Related Accession #
Q9NS00
GenBank Nucleotide #
NM_020156.4
NCBI Official Full Name
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
NCBI Official Synonym Full Names
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
NCBI Official Symbol
C1GALT1
NCBI Official Synonym Symbols
C1GALT; T-synthase
UniProt Protein Name
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
UniProt Synonym Protein Names
B3Gal-T8; Core 1 O-glycan T-synthase; Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; Beta-1,3-galactosyltransferase; Core 1 beta1,3-galactosyltransferase 1; C1GalT1; Core 1 beta3-Gal-T1
Protein Family
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase
UniProt Gene Name
C1GALT1
UniProt Synonym Gene Names
Beta-1,3-galactosyltransferase; C1GalT1; Core 1 beta3-Gal-T1
UniProt Entry Name
C1GLT_HUMAN
NCBI Protein Information
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; B3Gal-T8; core 1 O-glycan T-synthase; core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; core 1 beta3-Gal-T1; core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1

NCBI Summary for C1GALT1

The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis.[provided by RefSeq, Sep 2010]
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UniProt Comments for C1GALT1

C1GALT1: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development. Belongs to the glycosyltransferase 31 family. Beta3- Gal-T subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; EC 2.4.1.122; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7p21.3

Cellular Component: Golgi membrane; integral to membrane

Molecular Function: protein binding; metal ion binding; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity

Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; angiogenesis; kidney development; post-translational protein modification
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Research Articles on C1GALT1

1. C1GALT1 overexpression modifies O-glycans on FGFR2 and enhances its phosphorylation to promote the invasive behavior and cancer stem-like property in colon cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with C1GALT1 recombinant protein

 Reference Product  PubMed Publications
 C1GALT1C1 recombinant protein  >13 publications with C1GALT1 and C1GALT1C1
 ST3GAL2 recombinant protein  >1 publications with C1GALT1 and ST3GAL2
 ST6GALNAC1 recombinant protein  >1 publications with C1GALT1 and ST6GALNAC1

Pathways associated with C1GALT1 recombinant protein

 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Mucin Type O-Glycan Biosynthesis Pathway antibodies  Mucin Type O-Glycan Biosynthesis Pathway Diagram
 Mucin Type O-Glycan Biosynthesis Pathway antibodies  Mucin Type O-Glycan Biosynthesis Pathway Diagram
 O-glycan Biosynthesis, Mucin Type Core Pathway antibodies  O-glycan Biosynthesis, Mucin Type Core Pathway Diagram
 O-glycan Biosynthesis, Mucin Type Core Pathway antibodies  O-glycan Biosynthesis, Mucin Type Core Pathway Diagram
 O-linked Glycosylation Pathway antibodies  O-linked Glycosylation Pathway Diagram
 O-linked Glycosylation Of Mucins Pathway antibodies  O-linked Glycosylation Of Mucins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Mucin Core 1 And Core 2 O-glycosylation Pathway antibodies  Mucin Core 1 And Core 2 O-glycosylation Pathway Diagram

Diseases associated with C1GALT1 recombinant protein

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >17 publications with C1GALT1 and Kidney Diseases
 Carcinoma Antibodies  >4 publications with C1GALT1 and Carcinoma
 Proteinuria Antibodies  >4 publications with C1GALT1 and Proteinuria
 Adenocarcinoma Antibodies  >3 publications with C1GALT1 and Adenocarcinoma
 Inflammation Antibodies  >2 publications with C1GALT1 and Inflammation
 Neoplasm Metastasis Antibodies  >2 publications with C1GALT1 and Neoplasm Metastasis
 Liver Diseases Antibodies  >2 publications with C1GALT1 and Liver Diseases
 Blood Coagulation Disorders Antibodies  >2 publications with C1GALT1 and Blood Coagulation Disorders
 Carcinoma, Hepatocellular Antibodies  >2 publications with C1GALT1 and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >1 publications with C1GALT1 and Breast Neoplasms

Organs/Tissues associated with C1GALT1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >9 publications with C1GALT1 and Kidney
 Eye Antibodies  >3 publications with C1GALT1 and Eye
 Ovary Antibodies  >3 publications with C1GALT1 and Ovary
 Bone Antibodies  >3 publications with C1GALT1 and Bone
 Intestine Antibodies  >2 publications with C1GALT1 and Intestine
 Liver Antibodies  >2 publications with C1GALT1 and Liver
 Bone Marrow Antibodies  >2 publications with C1GALT1 and Bone Marrow
 Uterus Antibodies  >1 publications with C1GALT1 and Uterus
 Stomach Antibodies  >1 publications with C1GALT1 and Stomach
 Placenta Antibodies  >1 publications with C1GALT1 and Placenta
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