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Erythropoietin-Alpha (EPO) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146280

Description: 800x600 EPO a Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 189 amino acids (28-193a.a.) and having a molecular mass of 20.9kDa.EPO a is fused to a 23 amino acid His-tag at N-terminus & purified… More details

$250 / 0.002 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
Erythropoietin-alpha (EPO), Recombinant Protein
Full Product Name
Recombinant Human Erythropoietin-alpha, His Tag
Product Gene Name
EPO recombinant protein
Product Synonym Names
EPO a Human, His; Erythropoietin-alpha Human Recombinant, His Tag; 800x600 Erythropoietin; EP; INN=Epoetin; EPO a; Erythropoietin-alpha; EPO. 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UnhideWhenUsed="false" Name="Colorful Grid Accent 6"/> UnhideWhenUsed="false" QFormat="true" Name="Subtle Emphasis"/> UnhideWhenUsed="false" QFormat="true" Name="Intense Emphasis"/> UnhideWhenUsed="false" QFormat="true" Name="Subtle Reference"/> UnhideWhenUsed="false" QFormat="true" Name="Intense Reference"/> UnhideWhenUsed="false" QFormat="true" Name="Book Title"/> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Calibri"; "sans-serif"; }; EPO a His
Sequence
MGSSHHHHHH SSGLVPRGSH MGSAPP RLIC DSRVLERYLL EAKEAENITT GCAEHCSLNE NITVPDTKVN FYAWKRMEVG QQAVEVWQGL ALLSEAVLRG QALLVNSSQP WEPLQLHVDK AVSGLRSLTT LLRALRAQKE AISPPDAASA APLRTITADT FRKLFRVYSN FLRGKLKLYT GEACRTGDR.
Host
E Coli
Form/Format
800x600 800x600 EPO a protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. Normal 0 false false false EN-US X-NONE HE MicrosoftInternetExplorer4 DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleC
Purity/Purification
Greater than 80% as determined by SDS-PAGE.
Molecular Weight
21,307 Da
OMIM
133170
3D Structure
ModBase 3D Structure for P01588

Product Categories/Family for EPO recombinant protein

Cytokines and Growth Factors; Growth Factors; Erythropoietin

Other Notes

Small volumes of EPO recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EPO purchase

MBS146280 is a recombinant protein targeting EPO. Also known as Recombinant Human Erythropoietin-alpha, His Tag. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for EPO. It may not necessarily be applicable to this product.

NCBI GI #
62240997
NCBI GeneID
2056
NCBI Accession #
NP_000790.2
UniProt Primary Accession #
P01588
UniProt Secondary Accession #
Q2M2L6; Q549U2; Q9UDZ0; Q9UEZ5; Q9UHA0
UniProt Related Accession #
P01588
GenBank Nucleotide #
NM_000799.2
NCBI Official Full Name
erythropoietin
NCBI Official Synonym Full Names
erythropoietin
NCBI Official Symbol
EPO
NCBI Official Synonym Symbols
EP; MVCD2
UniProt Protein Name
Erythropoietin
UniProt Synonym Protein Names
INN: Epoetin
Protein Family
Erythropoietin
UniProt Gene Name
EPO
UniProt Entry Name
EPO_HUMAN
NCBI Protein Information
erythropoietin; epoetin

NCBI Summary for EPO

This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008]
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UniProt Comments for EPO

EPO: Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the EPO/TPO family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: extracellular space; cell surface; extracellular region

Molecular Function: protein binding; erythropoietin receptor binding; hormone activity; protein kinase activator activity

Biological Process: hemoglobin biosynthetic process; erythrocyte maturation; blood circulation; apoptosis; positive regulation of transcription, DNA-dependent; response to lipopolysaccharide; response to testosterone stimulus; signal transduction; response to salt stress; response to vitamin A; peptidyl-serine phosphorylation; response to hyperoxia; positive regulation of tyrosine phosphorylation of Stat5 protein; response to estrogen stimulus; positive regulation of protein kinase activity; positive regulation of cell proliferation; positive regulation of Ras protein signal transduction; response to axon injury; response to electrical stimulus; positive regulation of neuron differentiation; embryo implantation; positive regulation of DNA replication; aging

Disease: Microvascular Complications Of Diabetes, Susceptibility To, 2
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Research Articles on EPO

1. Studies indicate that the signalling mediated by EPO is required for normal brain development.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with EPO recombinant protein

 Reference Product  PubMed Publications
 EPOR recombinant protein  >727 publications with EPO and EPOR
 JAK2 recombinant protein  >326 publications with EPO and JAK2
 TNF recombinant protein  >285 publications with EPO and TNF
 HIF1A recombinant protein  >260 publications with EPO and HIF1A
 STAT3 recombinant protein  >82 publications with EPO and STAT3
 VEGFA recombinant protein  >47 publications with EPO and VEGFA
 GATA2 recombinant protein  >28 publications with EPO and GATA2
 TFRC recombinant protein  >4 publications with EPO and TFRC

Pathways associated with EPO recombinant protein

 Products by Pathway  Pathway Diagram
 Cellular Response To Hypoxia Pathway antibodies  Cellular Response To Hypoxia Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 EPO Receptor Signaling Pathway antibodies  EPO Receptor Signaling Pathway Diagram
 EPO Signaling Pathway antibodies  EPO Signaling Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 HIF-2-alpha Transcription Factor Network Pathway antibodies  HIF-2-alpha Transcription Factor Network Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with EPO recombinant protein

 Disease Name  Pubmed Publications
 Anemia Antibodies  >2805 publications with EPO and Anemia
 Kidney Diseases Antibodies  >1371 publications with EPO and Kidney Diseases
 Renal Insufficiency Antibodies  >1006 publications with EPO and Renal Insufficiency
 Kidney Failure, Chronic Antibodies  >926 publications with EPO and Kidney Failure, Chronic
 Vascular Diseases Antibodies  >885 publications with EPO and Vascular Diseases
 Nervous System Diseases Antibodies  >693 publications with EPO and Nervous System Diseases
 Inflammation Antibodies  >594 publications with EPO and Inflammation
 Central Nervous System Diseases Antibodies  >521 publications with EPO and Central Nervous System Diseases
 Necrosis Antibodies  >368 publications with EPO and Necrosis
 Heart Diseases Antibodies  >366 publications with EPO and Heart Diseases

Organs/Tissues associated with EPO recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >809 publications with EPO and Brain
 Eye Antibodies  >159 publications with EPO and Eye
 Testis Antibodies  >33 publications with EPO and Testis
 Prostate Antibodies  >32 publications with EPO and Prostate
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