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LIGHT (mTNFSF14) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146285

Description: TNFSF14 Mouse Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 168 amino acids and having a molecular mass of 18.4kDa.Introduction: TNFRSF14, a member of the TNF receptor superfamily, is a type I… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LIGHT (mTNFSF14), Recombinant Protein
Full Product Name
Recombinant Mouse LIGHT
Product Gene Name
mTNFSF14 recombinant protein
Product Synonym Names
TNFSF14 Mouse; LIGHT Mouse Recombinant; Tumor necrosis factor ligand superfamily member 14; CD258; Tnfsf14; Light
Sequence
DGGKGSWEKL IQDQRSHQAN PAAHLTGANA SLIGIGGPLL WETRLGLAFL RGLTYHDGAL VTMEPGYYYV YSKVQLSGVG CPQGLANGLP ITHGLYKRTS RYPKELELLV SRRSPCGRAN SSRVWWDSSF LGGVVHLEAG EEVVVRVPGN RLVRPRDGTR SYFGAFMV
Host
E Coli
Form/Format
TNFSF14 protein was lyophilized from a 0.2 um filtered concentrated solution in PBS pH7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Greater than 96.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Preparation and Storage
Lyophilized TNFSF14 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution TNFSF14 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Molecular Weight
26,338 Da
3D Structure
ModBase 3D Structure for Q9QYH9

Product Categories/Family for mTNFSF14 recombinant protein

Cytokines and Growth Factors; Cytokines; Tumor Necrosis Factor

Other Notes

Small volumes of mTNFSF14 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mTNFSF14 purchase

MBS146285 is a recombinant protein targeting mTNFSF14. Also known as Recombinant Mouse LIGHT. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for mTNFSF14. It may not necessarily be applicable to this product.

NCBI GI #
9507195
NCBI GeneID
50930
NCBI Accession #
NP_062291.1
UniProt Primary Accession #
Q9QYH9
UniProt Secondary Accession #
Q059Y9
UniProt Related Accession #
Q9QYH9
GenBank Nucleotide #
NM_019418.3
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 14
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 14
NCBI Official Symbol
Tnfsf14
NCBI Official Synonym Symbols
LTg; HVEML; LIGHT; Ly113; HVEM-L
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 14
UniProt Synonym Protein Names
CD_antigen: CD258Cleaved into the following 2 chains:Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form
Protein Family
Light-activated DNA-binding protein
UniProt Gene Name
Tnfsf14
UniProt Synonym Gene Names
Light
UniProt Entry Name
TNF14_MOUSE
NCBI Protein Information
tumor necrosis factor ligand superfamily member 14

UniProt Comments for mTNFSF14

TNFSF14: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Inhibitor; Membrane protein, integral

Cellular Component: extracellular space; membrane; integral to membrane; extracellular region; plasma membrane

Molecular Function: caspase inhibitor activity; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: release of cytoplasmic sequestered NF-kappaB; T cell costimulation; immune response; negative regulation of caspase activity; positive regulation of myoblast differentiation
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Research Articles on mTNFSF14

1. LIGHT protein is rapidly and transiently expressed after T-cell activation, and this expression is stronger on CD8 T cells than on CD4 T cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with mTNFSF14 recombinant protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram

Diseases associated with mTNFSF14 recombinant protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >224 publications with mTNFSF14 and Necrosis
 Inflammation Antibodies  >59 publications with mTNFSF14 and Inflammation
 Immune System Diseases Antibodies  >44 publications with mTNFSF14 and Immune System Diseases
 Disease Models, Animal Antibodies  >21 publications with mTNFSF14 and Disease Models, Animal
 Liver Diseases Antibodies  >14 publications with mTNFSF14 and Liver Diseases
 Neoplasms, Experimental Antibodies  >11 publications with mTNFSF14 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >10 publications with mTNFSF14 and Cardiovascular Diseases
 Lung Diseases Antibodies  >8 publications with mTNFSF14 and Lung Diseases
 Brain Diseases Antibodies  >7 publications with mTNFSF14 and Brain Diseases
 Breast Neoplasms Antibodies  >5 publications with mTNFSF14 and Breast Neoplasms

Organs/Tissues associated with mTNFSF14 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >15 publications with mTNFSF14 and Bone Marrow
 Skin Antibodies  >7 publications with mTNFSF14 and Skin
 Thymus Antibodies  >6 publications with mTNFSF14 and Thymus
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