Human KRT16 Recombinant Protein – Cat# MBS146291

Cytokeratin 16 (KRT16) Human Recombinant Protein

Name: KRT16 Recombinant Protein; Cytokeratin 16; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146291
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146291

Description: KRT16 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 496 amino acids (1-473) and having a molecular mass of 53.7 kDa.KRT16 is fused to a 23 amino acid His-Tag at N-terminus and purified by… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cytokeratin 16 (KRT16), Recombinant Protein

Full Product Name

Recombinant Human Cytokeratin 16

Product Gene Name

KRT16 recombinant protein

Product Synonym Names

KRT16 Human; Cytokeratin 16 Human Recombinant; Keratin; type I cytoskeletal 16; Cytokeratin 16; KRT16; Cytokeratin-16; CK-16; Keratin-16; K16; KRT16A; FNEPPK; K1CP; NEPPK

Sequence

MGSSHHH HHH SSGLVPRGSH MGSMTT CSRQ FTSSSSMKGS CGIGGGIGGG SSRISSVLAG GSCRAPSTYG GGLSVSSRFS SGGACGLGGG YGGGFSSSSS FGSGFGGGYG GGLGAGFGGG LGAGFGGGFA GGDGLLVGSE KVTMQNLNDR LASYLDKVRA LEEANADLEV KIRDWYQRQR PSEIKDYSPY FKTIEDLRNK IIAATIENAQ PILQIDNARL AADDFRTKYE HELALRQTVE ADVNGLRRVL DELTLARTDL EMQIEGLKEE LAYLRKNHEE EMLALRGQTG GDVNVEMDAA PGVDLSRILN EMRDQYEQMA EKNRRDAETW FLSKTEELNK EVASNSELVQ SSRSEVTELR RVLQGLEIEL QSQLSMKASL ENSLEETKGR YCMQLSQIQG LIGSVEEQLA QLRCEMEQQS QEYQILLDVK TRLEQEIATY RRLLEGEDAH LSSQQASGQS YSSREVFTSS SSSSSRQTRP ILKEQSSSSF SQGQSS.

Host

E Coli

Form/Format

The KRT16 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Molecular Weight

51,268 Da

OMIM

144200

3D Structure

ModBase 3D Structure for P08779

Product Categories/Family for KRT16 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Cytokeratin

Other Notes

Small volumes of KRT16 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KRT16 purchase

MBS146291 is a recombinant protein targeting KRT16. Also known as Recombinant Human Cytokeratin 16. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for KRT16. It may not necessarily be applicable to this product.

NCBI GI #

24430192

NCBI GeneID

3868

NCBI Accession #

NP_005548.2

UniProt Primary Accession #

P08779

UniProt Secondary Accession #

P30654; Q16402; Q9UBG8; A8K488

UniProt Related Accession #

P08779

GenBank Nucleotide #

NM_005557.3

NCBI Official Full Name

keratin, type I cytoskeletal 16

NCBI Official Synonym Full Names

keratin 16, type I

NCBI Official Symbol

KRT16

NCBI Official Synonym Symbols

K16; PC1; CK16; K1CP; NEPPK; FNEPPK; KRT16A

UniProt Protein Name

Keratin, type I cytoskeletal 16

UniProt Synonym Protein Names

Cytokeratin-16; CK-16; Keratin-16; K16

Protein Family

Keratin

UniProt Gene Name

KRT16

UniProt Synonym Gene Names

KRT16A; CK-16; K16

UniProt Entry Name

K1C16_HUMAN

NCBI Protein Information

keratin, type I cytoskeletal 16; CK-16; cytokeratin 16; cytokeratin-16; focal non-epidermolytic palmoplantar keratoderma

NCBI Summary for KRT16

The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]

UniProt Comments for KRT16

K16: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6. K16 and K17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cytoskeleton; intermediate filament; nucleus

Molecular Function: protein binding; structural constituent of cytoskeleton

Biological Process: epidermis development; intermediate filament cytoskeleton organization and biogenesis; cytoskeleton organization and biogenesis; keratinocyte migration; hair cycle; keratinocyte differentiation; cell proliferation; keratinization; innate immune response; morphogenesis of an epithelium; inflammatory response; negative regulation of cell migration; aging

Disease: Palmoplantar Keratoderma, Nonepidermolytic, Focal; Pachyonychia Congenita 1

Research Articles on KRT16

1. The wider spectrum of KRT16 mutations suggests that changes in codons 125, 127, and 132 are most commonly responsible for PC-1 and that proline substitution mutations at codons 127 or 128 may produce more severe disease

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with KRT16 recombinant protein

Reference Product	PubMed Publications
KRT17 recombinant protein	>25 publications with KRT16 and KRT17
KRT14 recombinant protein	>4 publications with KRT16 and KRT14
SPRR1A recombinant protein	>2 publications with KRT16 and SPRR1A
FLG recombinant protein	>1 publications with KRT16 and FLG

Diseases associated with KRT16 recombinant protein

Disease Name	Pubmed Publications
Pachyonychia Congenita Antibodies	>28 publications with KRT16 and Pachyonychia Congenita
Inflammation Antibodies	>3 publications with KRT16 and Inflammation
Carcinoma, Squamous Cell Antibodies	>2 publications with KRT16 and Carcinoma, Squamous Cell
Neoplasms, Experimental Antibodies	>2 publications with KRT16 and Neoplasms, Experimental
Necrosis Antibodies	>2 publications with KRT16 and Necrosis
Breast Neoplasms Antibodies	>2 publications with KRT16 and Breast Neoplasms
Keratoderma, Palmoplantar, Epidermolytic Antibodies	>2 publications with KRT16 and Keratoderma, Palmoplantar, Epidermolytic
Skin Neoplasms Antibodies	>1 publications with KRT16 and Skin Neoplasms
Neoplasm Metastasis Antibodies	>1 publications with KRT16 and Neoplasm Metastasis
Testicular Diseases Antibodies	>1 publications with KRT16 and Testicular Diseases

Organs/Tissues associated with KRT16 recombinant protein

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>24 publications with KRT16 and Skin
Blood Antibodies	>6 publications with KRT16 and Blood
Mouth Antibodies	>6 publications with KRT16 and Mouth
Embryonic Tissue Antibodies	>2 publications with KRT16 and Embryonic Tissue
Connective Tissue Antibodies	>1 publications with KRT16 and Connective Tissue
Kidney Antibodies	>1 publications with KRT16 and Kidney
Brain Antibodies	>1 publications with KRT16 and Brain
Intestine Antibodies	>1 publications with KRT16 and Intestine
Larynx Antibodies	>1 publications with KRT16 and Larynx