Human WFDC2 Recombinant Protein – Cat# MBS146331

WAP Four-Disulfide Core Domain 2 (WFDC2) Human Recombinant Protein

Name: WFDC2 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146331
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146331

Description: WFDC2 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain (31-124) containing 104 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 11.3kDa (calculated).Introduction: WAP… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

WAP Four-Disulfide Core Domain 2 (WFDC2), Recombinant Protein

Full Product Name

Recombinant Human WAP Four-Disulfide Core Domain 2

Product Gene Name

WFDC2 recombinant protein

Product Synonym Names

WFDC2 Human; WAP Four-Disulfide Core Domain 2 Human Recombinant; WAP four-disulfide core domain protein 2; Epididymal secretory protein E4; Major epididymis-specific protein E4; Putative protease inhibitor WAP5; WFDC2; HE4; WAP5; EDDM4; dJ461P17.6

Sequence

MKHHHHH HASEKT GVCPELQ ADQNCTQECV SDSECADNLK CCSAGCATFC SLPNDKEGSC PQVNINFPQL GLCRDQCQVD SQCPGQMKCC RNGCGKVSCV TPNF.

Host

E Coli

Form/Format

WFDC2 filtered (0.4 um) and lyophilized from 0.5mg/ml in PBS buffer, pH 7.5.
Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Purity as determined by densitometric image analysis is greater than 95%.

Preparation and Storage

Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.

Molecular Weight

11,043 Da

3D Structure

ModBase 3D Structure for Q14508

Solubility

It is recommended to add 200 ul deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. WFDC2 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

Product Categories/Family for WFDC2 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of WFDC2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WFDC2 purchase

MBS146331 is a recombinant protein targeting WFDC2. Also known as Recombinant Human WAP Four-Disulfide Core Domain 2. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for WFDC2. It may not necessarily be applicable to this product.

NCBI GI #

56699495

NCBI GeneID

10406

NCBI Accession #

NP_006094.3

UniProt Primary Accession #

Q14508

UniProt Secondary Accession #

Q6IB27; Q8WXV9; Q8WXW0; Q8WXW1; Q8WXW2; Q96KJ1; A2A2A5; A2A2A6; A6PVD5

UniProt Related Accession #

Q14508

GenBank Nucleotide #

NM_006103.3

NCBI Official Full Name

WAP four-disulfide core domain protein 2

NCBI Official Synonym Full Names

WAP four-disulfide core domain 2

NCBI Official Symbol

WFDC2

NCBI Official Synonym Symbols

HE4; WAP5; EDDM4; dJ461P17.6

UniProt Protein Name

WAP four-disulfide core domain protein 2

UniProt Synonym Protein Names

Epididymal secretory protein E4; Major epididymis-specific protein E4; Putative protease inhibitor WAP5

Protein Family

WAP four-disulfide core domain protein

UniProt Gene Name

WFDC2

UniProt Synonym Gene Names

HE4; WAP5

UniProt Entry Name

WFDC2_HUMAN

NCBI Protein Information

WAP four-disulfide core domain protein 2; WAP domain containing protein HE4-V4; epididymal protein 4; epididymal secretory protein E4; epididymis-specific, whey-acidic protein type, four-disulfide core; major epididymis-specific protein E4; putative protease inhibitor WAP5

NCBI Summary for WFDC2

This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]

UniProt Comments for WFDC2

WFDC2: a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: extracellular space

Molecular Function: serine-type endopeptidase inhibitor activity; aspartic-type endopeptidase inhibitor activity; endopeptidase inhibitor activity; cysteine protease inhibitor activity

Biological Process: spermatogenesis; proteolysis

Research Articles on WFDC2

1. the HE4 marker appears to be helpful in forecasting of optimal cytoreduction and possibly also of the prediction of response to platinum analogues used in first-line treatment of ovarian cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with WFDC2 recombinant protein

Disease Name	Pubmed Publications
Ovarian Neoplasms Antibodies	>108 publications with WFDC2 and Ovarian Neoplasms
Carcinoma Antibodies	>43 publications with WFDC2 and Carcinoma
Endometrial Neoplasms Antibodies	>24 publications with WFDC2 and Endometrial Neoplasms
Adenocarcinoma Antibodies	>21 publications with WFDC2 and Adenocarcinoma
Lung Neoplasms Antibodies	>12 publications with WFDC2 and Lung Neoplasms
Breast Neoplasms Antibodies	>7 publications with WFDC2 and Breast Neoplasms
Infertility, Female Antibodies	>3 publications with WFDC2 and Infertility, Female
Fibrosis Antibodies	>2 publications with WFDC2 and Fibrosis
Cardiovascular Diseases Antibodies	>2 publications with WFDC2 and Cardiovascular Diseases
Inflammation Antibodies	>2 publications with WFDC2 and Inflammation

Organs/Tissues associated with WFDC2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Epididymis Antibodies	>78 publications with WFDC2 and Epididymis
Ovary Antibodies	>14 publications with WFDC2 and Ovary
Lung Antibodies	>12 publications with WFDC2 and Lung
Uterus Antibodies	>6 publications with WFDC2 and Uterus
Prostate Antibodies	>4 publications with WFDC2 and Prostate
Kidney Antibodies	>3 publications with WFDC2 and Kidney
Trachea Antibodies	>3 publications with WFDC2 and Trachea
Heart Antibodies	>2 publications with WFDC2 and Heart
Mammary Gland Antibodies	>2 publications with WFDC2 and Mammary Gland
Muscle Antibodies	>2 publications with WFDC2 and Muscle