• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CCR4-NOT Transcription Complex, Subunit 8 (CNOT8) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146335

Description: CNOT8 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 315 amino acids (1-292) and having a molecular mass of 35.9 kDa.CNOT8 is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

$250 / 0.005 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CCR4-NOT Transcription Complex, Subunit 8 (CNOT8), Recombinant Protein
Full Product Name
Recombinant Human CCR4-NOT Transcription Complex, Subunit 8
Product Gene Name
CNOT8 recombinant protein
Product Synonym Names
CNOT8 Human; CCR4-NOT Transcription Complex, Subunit 8 Human Recombinant; CCR4-NOT transcription complex subunit 8; CAF1; CALIF; hCAF1; POP2; CAF1-like protein; CAF2; CCR4-associated factor 8; Caf1b; CNOT8
Sequence
MGSSHHH HHH SSGLVPRGSH MGSMPA ALVE NSQVICEVWA SNLEEEMRKI REIVLSYSYI AMDTEFPGVV VRPIGEFRSS IDYQYQLLRC NVDLLKIIQL GLTFTNEKGE YPSGINTWQF NFKFNLTEDM YSQDSIDLLA NSGLQFQKHE EEGIDTLHFA ELLMTSGVVL CDNVKWLSFH SGYDFGYMVK LLTDSRLPEE EHEFFHILNL FFPSIYDVKY LMKSCKNLKG GLQEVADQLD LQRIGRQHQA GSDSLLTGMA FFRMKELFFE DSIDDAKYCG RLYGLGTGVA QKQNEDVDSA QEKMSILAII NNMQQ.
Host
E Coli
Form/Format
The CNOT8 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Sterile Filtered colorless solution.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Molecular Weight
27,415 Da
OMIM
603731
3D Structure
ModBase 3D Structure for Q9UFF9

Product Categories/Family for CNOT8 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of CNOT8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CNOT8 purchase

MBS146335 is a recombinant protein targeting CNOT8. Also known as Recombinant Human CCR4-NOT Transcription Complex, Subunit 8. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CNOT8. It may not necessarily be applicable to this product.

NCBI GI #
666637944
NCBI GeneID
9337
NCBI Accession #
NP_001288002.1
UniProt Primary Accession #
Q9UFF9
UniProt Secondary Accession #
O95709; Q7Z521; Q9H6Y1; B0AZS3; B2RAR8; B7Z8R1; D3DQI8
UniProt Related Accession #
Q9UFF9
GenBank Nucleotide #
NM_001301073.1
NCBI Official Full Name
CCR4-NOT transcription complex subunit 8 isoform 1
NCBI Official Synonym Full Names
CCR4-NOT transcription complex, subunit 8
NCBI Official Symbol
CNOT8
NCBI Official Synonym Symbols
CAF1; POP2; CALIF; Caf1b; hCAF1
UniProt Protein Name
CCR4-NOT transcription complex subunit 8
UniProt Synonym Protein Names
CAF1-like protein; CALIFp; CAF2; CCR4-associated factor 8; Caf1b
Protein Family
CCR4-NOT transcription complex
UniProt Gene Name
CNOT8
UniProt Synonym Gene Names
CALIF; POP2; CALIFp
UniProt Entry Name
CNOT8_HUMAN
NCBI Protein Information
CCR4-NOT transcription complex subunit 8; CAF1-like protein; CAF2; CALIFp; CCR4-associated factor 8; PGK promoter directed over production

UniProt Comments for CNOT8

CNOT8: Ubiquitous transcription factor required for a diverse set of processes. The CCR4-NOT complex functions as general transcription regulation complex. Belongs to the CAF1 family.

Protein type: EC 3.1.13.4

Chromosomal Location of Human Ortholog: 5q31-q33

Cellular Component: intracellular; cytosol; nucleus; CCR4-NOT complex

Molecular Function: protein binding; 3'-5'-exoribonuclease activity; poly(A)-specific ribonuclease activity; RNA binding; metal ion binding; transcription factor activity

Biological Process: regulation of translation; negative regulation of cell proliferation; poly(A) tail shortening; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of cell proliferation; gene expression; miRNA-mediated gene silencing; mRNA catabolic process, deadenylation-dependent decay
Show more

Research Articles on CNOT8

1. The loss of CAF-1 p48 subunit causes a strong defect in packaging DNA into nucleosomes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CNOT8 recombinant protein

 Reference Product  PubMed Publications
 BTG1 recombinant protein  >7 publications with CNOT8 and BTG1
 CNOT1 recombinant protein  >7 publications with CNOT8 and CNOT1
 BTG2 recombinant protein  >6 publications with CNOT8 and BTG2
 CNOT6L recombinant protein  >5 publications with CNOT8 and CNOT6L
 CNOT6 recombinant protein  >5 publications with CNOT8 and CNOT6
 CNOT3 recombinant protein  >3 publications with CNOT8 and CNOT3
 CNOT10 recombinant protein  >1 publications with CNOT8 and CNOT10
 CNOT4 recombinant protein  >1 publications with CNOT8 and CNOT4
 CNOT2 recombinant protein  >1 publications with CNOT8 and CNOT2

Pathways associated with CNOT8 recombinant protein

 Products by Pathway  Pathway Diagram
 Deadenylation Of MRNA Pathway antibodies  Deadenylation Of MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram

Diseases associated with CNOT8 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with CNOT8 and Inflammation
 Necrosis Antibodies  >2 publications with CNOT8 and Necrosis
 Genital Diseases, Male Antibodies  >1 publications with CNOT8 and Genital Diseases, Male

Organs/Tissues associated with CNOT8 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with CNOT8 and Brain
 Nerve Antibodies  >1 publications with CNOT8 and Nerve
 Kidney Antibodies  >1 publications with CNOT8 and Kidney
 Eye Antibodies  >1 publications with CNOT8 and Eye
 Vascular Antibodies  >1 publications with CNOT8 and Vascular
 Muscle Antibodies  >1 publications with CNOT8 and Muscle
 Blood Antibodies  >1 publications with CNOT8 and Blood
 Testis Antibodies  >1 publications with CNOT8 and Testis
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000