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Chitinase 3-Like 1 (CHI3L1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146347

Description: CHI3L1 Human Recombinant produced in CHO is a single, glycosylated polypeptide chain containing 408 amino acids (1-383) and having a molecular mass of 45.5kDa. CHI3L1 is fused to a 25 amino acid myc-His-tag at C-terminus & purified by proprietary… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Chitinase 3-Like 1 (CHI3L1), Recombinant Protein
Full Product Name
Recombinant Human Chitinase 3-Like 1
Product Gene Name
CHI3L1 recombinant protein
Product Synonym Names
CHI3L1 Human; Chitinase 3-Like 1 Human Recombinant; Chitinase 3-like 1; CHI3L1; Chitinase-3-like protein 1; 39 kDa synovial protein; Cartilage glycoprotein 39; CGP-39; GP-39; hCGP-39
Sequence
MGVKASQTGF VVLVLLQCCS AYKLVCYYTS WSQYREGDGS CFPDALDRFL CTHIIYSFAN ISNDHIDTWE WNDVTLYGML NTLKNRNPNL KTLLSVGGWN FGSQRFSKIA SNTQSRRTFI KSVPPFLRTH GFDGLDLAWL YPGRRDKQHF TTLIKEMKAE FIKEAQPGKK QLLLSAALSA GKVTIDSSYD IAKISQHLDF ISIMTYDFHG AWRGTTGHHS PLFRGQEDAS PDRFSNTDYA VGYMLRLGAP ASKLVMGIPT FGRSFTLASS ETGVGAPISG PGIPGRFTKE AGTLAYYEIC DFLRGATVHR ILGQQVPYAT KGNQWVGYDD QESVKSKVQY LKDRQLAGAM VWALDLDDFQ GSFCGQDLRF PLTNAIKDAL AATKLGP EQK LISEEDLNSA VDHHHHHH .
Host
Chinese Hamster Ovarian Cells (CHO)
Form/Format
The CHI3L1 solution (0.25mg/ml) contains Phosphate-Buffered Saline (pH 7.4).
Sterile Filtered colorless solution.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Molecular Weight
19,310 Da
OMIM
610603
3D Structure
ModBase 3D Structure for Q96Q83

Product Categories/Family for CHI3L1 recombinant protein

Enzymes

Other Notes

Small volumes of CHI3L1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHI3L1 purchase

MBS146347 is a recombinant protein targeting CHI3L1. Also known as Recombinant Human Chitinase 3-Like 1. Host: Chinese Hamster Ovarian Cells (CHO).

Additional Details

NCBI/Uniprot data below describe general gene information for CHI3L1. It may not necessarily be applicable to this product.

NCBI GI #
21040275
NCBI GeneID
221120
NCBI Accession #
NP_631917.1
UniProt Primary Accession #
Q96Q83
UniProt Secondary Accession #
Q3SYI0; Q6NX57; Q96BU8; A6NDJ1
UniProt Related Accession #
Q96Q83
GenBank Nucleotide #
NM_139178.3
NCBI Official Full Name
alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
NCBI Official Synonym Full Names
alkB, alkylation repair homolog 3 (E. coli)
NCBI Official Symbol
ALKBH3
NCBI Official Synonym Symbols
ABH3; PCA1; DEPC1; DEPC-1
UniProt Protein Name
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
UniProt Synonym Protein Names
Alkylated DNA repair protein alkB homolog 3; DEPC-1; Prostate cancer antigen 1
Protein Family
Chitinase-3-like protein
UniProt Gene Name
ALKBH3
UniProt Synonym Gene Names
ABH3; DEPC1
UniProt Entry Name
ALKB3_HUMAN
NCBI Protein Information
alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; alkylated DNA repair protein alkB homolog 3; prostate cancer antigen 1; prostate cancer antigen-1

NCBI Summary for CHI3L1

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
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UniProt Comments for CHI3L1

ALKBH3: Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Belongs to the alkB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Demethylase; EC 1.14.11.-; Hydrolase; DNA repair, damage

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus

Molecular Function: protein binding; L-ascorbic acid binding; ferrous iron binding; DNA-N1-methyladenine dioxygenase activity; DNA demethylase activity

Biological Process: cell proliferation; DNA dealkylation; DNA repair
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Research Articles on CHI3L1

1. ALKBH3 contributes to development of urothelial carcinomas by accelerating their survival, angiogenesis, and invasion

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CHI3L1 recombinant protein

 Reference Product  PubMed Publications
 ALKBH1 recombinant protein  >6 publications with CHI3L1 and ALKBH1
 FTO recombinant protein  >2 publications with CHI3L1 and FTO
 ALKBH4 recombinant protein  >1 publications with CHI3L1 and ALKBH4
 ALKBH8 recombinant protein  >1 publications with CHI3L1 and ALKBH8

Pathways associated with CHI3L1 recombinant protein

 Products by Pathway  Pathway Diagram
 ABH3 Mediated Reversal Of Alkylation Damage Pathway antibodies  ABH3 Mediated Reversal Of Alkylation Damage Pathway Diagram
 DNA Damage Reversal Pathway antibodies  DNA Damage Reversal Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Reversal Of Alkylation Damage By DNA Dioxygenases Pathway antibodies  Reversal Of Alkylation Damage By DNA Dioxygenases Pathway Diagram

Diseases associated with CHI3L1 recombinant protein

 Disease Name  Pubmed Publications
 Pancreatic Diseases Antibodies  >2 publications with CHI3L1 and Pancreatic Diseases
 Inflammation Antibodies  >1 publications with CHI3L1 and Inflammation
 Obesity Antibodies  >1 publications with CHI3L1 and Obesity
 Hyperplasia Antibodies  >1 publications with CHI3L1 and Hyperplasia
 Respiratory Tract Diseases Antibodies  >1 publications with CHI3L1 and Respiratory Tract Diseases
 Necrosis Antibodies  >1 publications with CHI3L1 and Necrosis

Organs/Tissues associated with CHI3L1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >4 publications with CHI3L1 and Prostate
 Bladder Antibodies  >1 publications with CHI3L1 and Bladder
 Pancreas Antibodies  >1 publications with CHI3L1 and Pancreas
 Intestine Antibodies  >1 publications with CHI3L1 and Intestine
 Lung Antibodies  >1 publications with CHI3L1 and Lung
 Brain Antibodies  >1 publications with CHI3L1 and Brain
 Vascular Antibodies  >1 publications with CHI3L1 and Vascular
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