Metastasis Suppressor 1 (BRMS1) Human Breast Cancer Recombinant Protein

MTSS1: an intracellular protein that binds to actin and cortactin, and possesses tumor suppressor activity. Binds to the cytoplasmic domain of receptor protein tyrosine phosphatase delta. Senses and induces curved membranous curvatures important for cellular polarization, mobilization and endocytosis. May be related to cancer progression or tumor metastasis in a variety of organ sites. Its expression is down-regulated by MiR-135a. Downregulated in prostate cancer. Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood. Belongs to the MTSS1 family. Three isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Tumor suppressor

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: ruffle; adherens junction; endocytic vesicle; cytoplasm; actin cytoskeleton

Molecular Function: actin monomer binding; actin filament binding; identical protein binding; protein binding; receptor binding

Biological Process: plasma membrane organization and biogenesis; in utero embryonic development; actin filament polymerization; microspike biogenesis; positive regulation of actin filament bundle formation; cell motility; actin cytoskeleton organization and biogenesis; cell adhesion; bone mineralization; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of epithelial cell proliferation