Asialoglycoprotein Receptor 2 (ASGR2) Human Recombinant Protein

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

ASGP-R: cell surface receptor that mediates the endocytosis of plasma glycoproteins in which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. It transports these glycoproteins via a series of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociates. Then the receptor is recycled back to the cell surface. There are four alternatively spliced transcript variants of this gene.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p

Cellular Component: integral to membrane

Molecular Function: protein binding; asialoglycoprotein receptor activity; carbohydrate binding

Biological Process: receptor-mediated endocytosis; cell surface receptor linked signal transduction; glycoprotein metabolic process; lipid homeostasis; regulation of protein stability; bone mineralization