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Neuromedin B (NMB) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146401

Description: NMB Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 120 amino acids (25-121) and having a molecular mass of 13.2 kDa.NMB is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Neuromedin B (NMB), Recombinant Protein
Full Product Name
Recombinant Human Neuromedin B
Product Gene Name
Product Synonym Names
NMB Human; Neuromedin B Human Recombinant; Neuromedin-B; NMB; Neuromedin-B-32; Neuromedin B
Sequence
MGSSHHH HHH SSGLVPRGSH MGSAPL SWDL PEPRSRASKI RVHSRGNLWA TGHFMGKKSL EPSSPSPLGT APHTSLRDQR LQLSHDLLGI LLLKKALGVS LSRPAPQIQY RRLLVQILQK .
Host
E Coli
Form/Format
The NMB solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.
Sterile Filtered colorless solution.
Purity/Purification
Greater than 85.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Molecular Weight
16,309 Da
OMIM
162340
3D Structure
ModBase 3D Structure for P08949

Other Notes

Small volumes of NMB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NMB purchase

MBS146401 is a recombinant protein targeting NMB. Also known as Recombinant Human Neuromedin B. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NMB. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
neuromedin-B isoform 1 preproprotein
NCBI Official Synonym Full Names
neuromedin B
NCBI Official Symbol
NMB
UniProt Protein Name
Neuromedin-B
Protein Family
UniProt Gene Name
NMB
UniProt Entry Name
NMB_HUMAN
NCBI Protein Information
neuromedin-B

NCBI Summary for NMB

This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
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UniProt Comments for NMB

NMB: Stimulates smooth muscle contraction in a manner similar to that of bombesin. Belongs to the bombesin/neuromedin-B/ranatensin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q22-qter

Cellular Component: neuron projection; extracellular region

Molecular Function: hormone activity; neuromedin B receptor binding

Biological Process: elevation of cytosolic calcium ion concentration; cell-cell signaling; neuropeptide signaling pathway; negative regulation of hormone secretion; positive regulation of cell proliferation; positive regulation of hormone secretion; glucose homeostasis; signal transduction; arachidonic acid secretion
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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