Midkine (MDK) Rat Active Protein

Name: MDK Active Protein; Midkine; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS146411
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146411

Description: Midkine Rat Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 120 amino acids and having a molecular mass of 13.2kDa.The Midkine Rat is purified by proprietary chromatographic techniques.Introduction:… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Midkine (Mdk), Active Protein

Full Product Name

Recombinant Rat Midkine

Product Gene Name

Mdk active protein

Product Synonym Names

Midkine Rat; Midkine Rat Recombinant; Midkine; MK; Mdk; rMidkine

Sequence

VAKKKDKVKK GSECSEWTWG PCTPSSKDCG MGFREGTCGA QTQRIHCKVP CNWKKEFGAD CKYKFESWGA CDGSTGTKAR QGTLKKARYN AQCQETIRVT KPCTSKTKSK AKAKKGKGKD

Host

E Coli

Form/Format

Lyophilized from a 0.2 um filtered concentrated solution in 1xPBS, pH 7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized Midkine Rat although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Midkine Rat should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.

Molecular Weight

15,406 Da

3D Structure

ModBase 3D Structure for Q9R1S9

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized Midkine Rat in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration range of 10-100 ng/ml.

Product Categories/Family for Mdk active protein

Cytokines and Growth Factors; Neurotrophins; Midkine

Other Notes

Small volumes of Mdk active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Mdk purchase

MBS146411 is an active protein targeting Mdk. Also known as Recombinant Rat Midkine. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Mdk. It may not necessarily be applicable to this product.

NCBI GI #

13540681

NCBI GeneID

81517

NCBI Accession #

NP_110486.1

UniProt Primary Accession #

Q9R1S9

UniProt Related Accession #

Q9R1S9

GenBank Nucleotide #

NM_030859.2

NCBI Official Full Name

midkine

NCBI Official Synonym Full Names

midkine

NCBI Official Symbol

Mdk

UniProt Protein Name

Midkine

Protein Family

Midkine

UniProt Gene Name

Mdk

UniProt Synonym Gene Names

UniProt Entry Name

MK_RAT

NCBI Protein Information

midkine; MK

NCBI Summary for Mdk

heparin-binding growth factor; involved in early fetal development of the rat adrenal [RGD, Feb 2006]

UniProt Comments for Mdk

Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development ().

Research Articles on Mdk

1. We hypothesize a role for these cytokines in mediating, at least in part, acute neuroprotective effects and chronic neurotrophic adaptations that contribute to drug dependence.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Mdk active protein

Products by Pathway	Pathway Diagram
NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies	NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By NOTCH Pathway antibodies	Signaling By NOTCH Pathway Diagram
Signaling By NOTCH2 Pathway antibodies	Signaling By NOTCH2 Pathway Diagram

Diseases associated with Mdk active protein

Disease Name	Pubmed Publications
Kidney Diseases Antibodies	>25 publications with Mdk and Kidney Diseases
Nervous System Diseases Antibodies	>21 publications with Mdk and Nervous System Diseases
Adenocarcinoma Antibodies	>18 publications with Mdk and Adenocarcinoma
Inflammation Antibodies	>13 publications with Mdk and Inflammation
Brain Diseases Antibodies	>13 publications with Mdk and Brain Diseases
Congenital Abnormalities Antibodies	>12 publications with Mdk and Congenital Abnormalities
Disease Models, Animal Antibodies	>12 publications with Mdk and Disease Models, Animal
Skin Diseases Antibodies	>9 publications with Mdk and Skin Diseases
Neoplasms, Experimental Antibodies	>8 publications with Mdk and Neoplasms, Experimental
Pain Antibodies	>8 publications with Mdk and Pain

Organs/Tissues associated with Mdk active protein

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>28 publications with Mdk and Kidney
Brain Antibodies	>23 publications with Mdk and Brain
Embryonic Tissue Antibodies	>10 publications with Mdk and Embryonic Tissue
Heart Antibodies	>6 publications with Mdk and Heart
Connective Tissue Antibodies	>4 publications with Mdk and Connective Tissue
Eye Antibodies	>2 publications with Mdk and Eye