Human DRAXIN Recombinant Protein – Cat# MBS1464145

DRAXIN Human Recombinant Protein

Name: DRAXIN Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1464145
Price: 440 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1464145

Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord.… More details

$440 / 0.02 mg (Yeast) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Draxin, Recombinant Protein

Full Product Name

Recombinant Human Draxin

Product Gene Name

DRAXIN recombinant protein

Product Synonym Names

Dorsal inhibitory axon guidance protein; Dorsal repulsive axon guidance protein; Neucrin

Sequence

GALAPGTPAR NLPENHIDLP GPALWTPQAS HHRRRGPGKK EWGPGLPSQA QDGAVVTATR QASRLPEAEG LLPEQSPAGL LQDKDLLLGL ALPYPEKENR PPGWERTRKR SREHKRRRDR LRLHQGRALV RGPSSLMKKA ELSEAQVLDA AMEESSTSLA PTMFFLTTFE AAPATEESLI LPVTSLRPQQ AQPRSDGEVM PTLDMALFDW TDYEDLKPDG WPSAKKKEKH RGKLSSDGNE TSPAEGEPCD HHQDCLPGTC CDLREHLCTP HNRGLNNKCF DDCMCVEGLR CYAKFHRNRR VTRRKGRCVE PETANGDQGS FINV

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

52 kDa

Sequence Positions

26-349aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

612682

3D Structure

ModBase 3D Structure for Q8NBI3

Species

Homo sapiens (Human)

Product Categories/Family for DRAXIN recombinant protein

Neuroscience

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for DRAXIN recombinant protein

"Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling." Miyake A., Takahashi Y., Miwa H., Shimada A., Konishi M., Itoh N. Biochem. Biophys. Res. Commun. 390:1051-1055(2009)

Other Notes

Small volumes of DRAXIN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DRAXIN purchase

MBS1464145 is a recombinant protein targeting DRAXIN. Also known as Recombinant Human Draxin. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for DRAXIN. It may not necessarily be applicable to this product.

NCBI GI #

86990448

NCBI GeneID

374946

NCBI Accession #

NP_940947.3

UniProt Primary Accession #

Q8NBI3

UniProt Secondary Accession #

Q5SNX0; Q6UWK8; B6EV15

GenBank Nucleotide #

NM_198545.3

NCBI Official Full Name

draxin

NCBI Official Synonym Full Names

dorsal inhibitory axon guidance protein

NCBI Official Symbol

DRAXIN

NCBI Official Synonym Symbols

UNQ3119; neucrin; AGPA3119; C1orf187

UniProt Protein Name

Draxin

UniProt Synonym Protein Names

Dorsal inhibitory axon guidance protein

Protein Family

Draxin

UniProt Gene Name

DRAXIN

UniProt Entry Name

DRAXI_HUMAN

NCBI Protein Information

draxin

UniProt Comments for DRAXIN

DRAXIN: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. Belongs to the draxin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: extracellular region

Molecular Function: protein binding

Biological Process: axon guidance; commissural neuron differentiation in the spinal cord; dorsal spinal cord development; forebrain development; negative regulation of axon extension; negative regulation of neuron apoptosis; Wnt receptor signaling pathway

Research Articles on DRAXIN

1. results suggest that draxin functions as a repulsive guidance cue for PCN migration. However, we observed no significant differences in PCN distribution between draxin(-/-) and wild type embryos.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with DRAXIN recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>10 publications with DRAXIN and Brain
Embryonic Tissue Antibodies	>4 publications with DRAXIN and Embryonic Tissue