Sorbin and SH3 Domain Containing 3 (SORBS3) Human Recombinant Protein

This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

vinexin: an adapter protein that contains three SH3 domains and is involved in the reorganization of actin cytoskeleton. Two alternatively spliced isoforms have been described. Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain. Both isoforms localize at focal adhesion and cell-cell adhesion sites; vinexin beta was also found in the nucleus. Interacts with DLG5 through its third SH3 domain. Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC) through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with SAFB2.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold; Cell adhesion; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: cytoskeleton; focal adhesion; nucleus; cytosol

Molecular Function: protein binding; structural constituent of cytoskeleton; transcription factor binding; vinculin binding

Biological Process: positive regulation of MAPKKK cascade; muscle contraction; positive regulation of stress fiber formation; actin filament organization; positive regulation of cytoskeleton organization and biogenesis; negative regulation of transcription from RNA polymerase II promoter; cell adhesion; cell-substrate adhesion