Phosphatase 1 (PPP1R3B) Recombinant Protein

This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011]

PPP1R3B: Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes.

Protein type: Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: intracellular membrane-bound organelle; glycogen granule; protein phosphatase type 1 complex

Molecular Function: enzyme binding; protein phosphatase regulator activity; phosphoprotein phosphatase activity

Biological Process: glycogen metabolic process; regulation of glycogen catabolic process; dephosphorylation; regulation of catalytic activity; regulation of glycogen biosynthetic process