Soluble RANK Receptor (sRANK) Human Active Protein

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]

TNFRSF11A: Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts (via cytoplasmic domain) with GAB2. Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q22.1

Cellular Component: integral to membrane; external side of plasma membrane

Molecular Function: protein binding; tumor necrosis factor receptor activity; transmembrane receptor activity; cytokine binding; metal ion binding; receptor activity

Biological Process: circadian thermoregulation; positive regulation of JNK activity; ossification; adaptive immune response; response to lipopolysaccharide; osteoclast differentiation; signal transduction; lymph node development; activation of NF-kappaB transcription factor; monocyte chemotaxis; response to radiation; cell-cell signaling; tumor necrosis factor-mediated signaling pathway; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of transcription factor activity

Disease: Osteopetrosis, Autosomal Recessive 7; Familial Expansile Osteolysis; Paget Disease Of Bone