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Sperm Autoantigenic (SPA17) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146557

Description: SPA17 Human Recombinant produced in E Coli is a single polypeptide chain containing 174 amino acids (1-151) and having a molecular mass of 19.8kDa. SPA17 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic… More details

$250 / 0.002 mg +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Sperm Autoantigenic (SPA17), Recombinant Protein
Full Product Name
Recombinant Human Sperm Autoantigenic Protein 17
Product Gene Name
Product Synonym Names
SPA17 Human; Sperm Autoantigenic Protein 17 Human Recombinant; CT22; SP17; SP17-1; Sperm surface protein Sp17; Cancer/testis antigen 22; Sperm autoantigenic protein 17; Sperm protein 17; SPA17
Sequence
MGSSHHH HHH SSGLVPRGSH MGSMSI PFSN THYRIPQGFG NLLEGLTREI LREQPDNIPA FAAAYFESLL EKREKTNFDP AEWGSKVEDR FYNNHAFEEQ EPPEKSDPKQ EESQISGKEE ETSVTILDSS EEDKEKEEVA AVKIQAAFRG HIAREEAKKM KTNSLQNEEK EENK
Host
E Coli
Form/Format
The SPA17 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Sterile Filtered colorless solution.
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Molecular Weight
17,406 Da
OMIM
608621
3D Structure
ModBase 3D Structure for Q15506

Other Notes

Small volumes of SPA17 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SPA17 purchase

MBS146557 is a recombinant protein targeting SPA17. Also known as Recombinant Human Sperm Autoantigenic Protein 17. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SPA17. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
sperm surface protein Sp17
NCBI Official Synonym Full Names
sperm autoantigenic protein 17
NCBI Official Symbol
SPA17
NCBI Official Synonym Symbols
CT22; SP17; SP17-1
UniProt Protein Name
Sperm surface protein Sp17
UniProt Synonym Protein Names
Cancer/testis antigen 22; CT22; Sp17-1; Sperm autoantigenic protein 17; Sperm protein 17
Protein Family
UniProt Gene Name
SPA17
UniProt Synonym Gene Names
SP17; CT22; Sperm protein 17
UniProt Entry Name
SP17_HUMAN
NCBI Protein Information
sperm surface protein Sp17; cancer/testis antigen 22; sperm protein 17

NCBI Summary for SPA17

This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]
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UniProt Comments for SPA17

SPA17: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

Protein type: Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 11q24.2

Cellular Component: membrane; cytoplasm

Molecular Function: calmodulin binding

Biological Process: binding of sperm to zona pellucida; single fertilization; spermatogenesis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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