Human MMP10 Recombinant Protein – Cat# MBS146623

Matrix Metalloproteinase 10 (MMP10) Human Recombinant Protein

Name: MMP10 Recombinant Protein; Matrix Metalloproteinase 10; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146623
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146623

Description: MMP10 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 401 amino acids (99-476a.a) and having a molecular mass of 45.4kDa. MMP10 is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Matrix Metalloproteinase 10 (MMP10), Recombinant Protein

Full Product Name

Recombinant Human Matrix Metalloproteinase 10

Product Gene Name

MMP10 recombinant protein

Product Synonym Names

MMP10 Human; Matrix Metallopeptidase 10 Human Recombinant; SL-2; STMY2; Stromelysin-2; Matrix metalloproteinase-10; MMP-10; Transin-2; MMP10

Sequence

MGSSHHH HHH SSGLVPRGSH MGSFSS FPGM PKWRKTHLTY RIVNYTPDLP RDAVDSAIEK ALKVWEEVTP LTFSRLYEGE ADIMISFAVK EHGDFYSFDG PGHSLAHAYP PGPGLYGDIH FDDDEKWTED ASGTNLFLVA AHELGHSLGL FHSANTEALM YPLYNSFTEL AQFRLSQDDV NGIQSLYGPP PASTEEPLVP TKSVPSGSEM PAKCDPALSF DAISTLRGEY LFFKDRYFWR RSHWNPEPEF HLISAFWPSL PSYLDAAYEV NSRDTVFIFK GNEFWAIRGN EVQAGYPRGI HTLGFPPTIR KIDAAVSDKE KKKTYFFAAD KYWRFDENSQ SMEQGFPRLI ADDFPGVEPK VDAVLQAFGF FYFFSGSSQF EFDPNARMVT HILKSNSWLH C

Host

E Coli

Form/Format

The MMP10 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 90% as determined by SDS-PAGE.

Molecular Weight

54,151 Da

OMIM

185260

3D Structure

ModBase 3D Structure for P09238

Product Categories/Family for MMP10 recombinant protein

Enzymes; Matrix Metalloproteinase

Other Notes

Small volumes of MMP10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MMP10 purchase

MBS146623 is a recombinant protein targeting MMP10. Also known as Recombinant Human Matrix Metalloproteinase 10. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP10. It may not necessarily be applicable to this product.

NCBI GI #

4505205

NCBI GeneID

4319

NCBI Accession #

NP_002416.1

UniProt Primary Accession #

P09238

UniProt Secondary Accession #

Q53HH9; B2R9X9

UniProt Related Accession #

P09238

GenBank Nucleotide #

NM_002425.2

NCBI Official Full Name

stromelysin-2 preproprotein

NCBI Official Synonym Full Names

matrix metallopeptidase 10

NCBI Official Symbol

MMP10

NCBI Official Synonym Symbols

SL-2; STMY2

UniProt Protein Name

Stromelysin-2

UniProt Synonym Protein Names

Matrix metalloproteinase-10; MMP-10; Transin-2

Protein Family

Stromelysin

UniProt Gene Name

MMP10

UniProt Synonym Gene Names

STMY2; SL-2; MMP-10

UniProt Entry Name

MMP10_HUMAN

NCBI Protein Information

stromelysin-2; MMP-10; matrix metallopeptidase 10 (stromelysin 2); matrix metalloprotease 10; matrix metalloproteinase 10 (stromelysin 2); matrix metalloproteinase-10; transin 2; transin-2

NCBI Summary for MMP10

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

UniProt Comments for MMP10

MMP10: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase. Belongs to the peptidase M10A family.

Protein type: Secreted; EC 3.4.24.22; Secreted, signal peptide; Protease; Extracellular matrix

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: zinc ion binding; metalloendopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; proteolysis; regulation of cell migration

Research Articles on MMP10

1. Taken together, our findings show that MMP-10 can play a significant role in tumor growth and progression, and that MMP-10 perturbation may represent a rational strategy for cancer treatment.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MMP10 recombinant protein

Reference Product	PubMed Publications
MMP1 recombinant protein	>41 publications with MMP10 and MMP1
MMP2 recombinant protein	>21 publications with MMP10 and MMP2
MMP7 recombinant protein	>15 publications with MMP10 and MMP7
TIMP1 recombinant protein	>14 publications with MMP10 and TIMP1
VEGFA recombinant protein	>9 publications with MMP10 and VEGFA
TNF recombinant protein	>7 publications with MMP10 and TNF
FOS recombinant protein	>6 publications with MMP10 and FOS

Pathways associated with MMP10 recombinant protein

Products by Pathway	Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Collagen Degradation Pathway antibodies	Collagen Degradation Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Matrix Metalloproteinases Pathway antibodies	Matrix Metalloproteinases Pathway Diagram

Diseases associated with MMP10 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>30 publications with MMP10 and Inflammation
Necrosis Antibodies	>16 publications with MMP10 and Necrosis
Adenocarcinoma Antibodies	>14 publications with MMP10 and Adenocarcinoma
Cardiovascular Diseases Antibodies	>14 publications with MMP10 and Cardiovascular Diseases
Lung Diseases Antibodies	>11 publications with MMP10 and Lung Diseases
Neoplasm Metastasis Antibodies	>11 publications with MMP10 and Neoplasm Metastasis
Lung Neoplasms Antibodies	>7 publications with MMP10 and Lung Neoplasms
Intestinal Neoplasms Antibodies	>6 publications with MMP10 and Intestinal Neoplasms
Heart Diseases Antibodies	>5 publications with MMP10 and Heart Diseases
Breast Neoplasms Antibodies	>5 publications with MMP10 and Breast Neoplasms

Organs/Tissues associated with MMP10 recombinant protein

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>32 publications with MMP10 and Vascular
Muscle Antibodies	>18 publications with MMP10 and Muscle
Lung Antibodies	>15 publications with MMP10 and Lung
Skin Antibodies	>10 publications with MMP10 and Skin
Mouth Antibodies	>8 publications with MMP10 and Mouth
Uterus Antibodies	>8 publications with MMP10 and Uterus
Brain Antibodies	>7 publications with MMP10 and Brain
Liver Antibodies	>6 publications with MMP10 and Liver
Intestine Antibodies	>4 publications with MMP10 and Intestine
Ovary Antibodies	>4 publications with MMP10 and Ovary