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Serine/Threonine-Protein Kinase Sgk3 (SGK3) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1466980

This gene is a member of the SerThr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride… More details

$1295 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Serine/threonine-protein kinase Sgk3 (SGK3), Recombinant Protein
Full Product Name
Recombinant Human Serine/threonine-protein kinase Sgk3 (SGK3)
Product Gene Name
SGK3 recombinant protein
Product Synonym Gene Name
SGK3
Sequence
MQRDHTMDYK ESCPSVSIPS SDEHREKKKR FTVYKVLVSV GRSEWFVFRR YAEFDKLYNT LKKQFPAMAL KIPAKRIFGD NFDPDFIKQR RAGLNEFIQN LVRYPELYNH PDVRAFLQMD SPKHQSDPSE DEDERSSQKL HSTSQNINLG PSGNPHAKPT DFDFLKVIGK GSFGKVLLAK RKLDGKFYAV KVLQKKIVLN RKEQKHIMAE RNVLLKNVKH PFLVGLHYSF QTTEKLYFVL DFVNGGELFF HLQRERSFPE HRARFYAAEI ASALGYLHSI KIVYRDLKPE NILLDSVGHV VLTDFGLCKE GIAISDTTTT FCGTPEYLAP EVIRKQPYDN TVDWWCLGAV LYEMLYGLPP FYCRDVAEMY DNILHKPLSL RPGVSLTAWS ILEELLEKDR QNRLGAKEDF LEIQNHPFFE SLSWADLVQK KIPPPFNPNV AGPDDIRNFD TAFTEETVPY SVCVSSDYSI VNASVLEADD AFVGFSYAPP SEDLFL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
53,306 Da
Sequence Positions
1-496, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
607591
3D Structure
ModBase 3D Structure for Q96BR1
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SGK3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SGK3 purchase

MBS1466980 is a recombinant protein targeting SGK3. Also known as Recombinant Human Serine/threonine-protein kinase Sgk3 (SGK3). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for SGK3. It may not necessarily be applicable to this product.

NCBI GI #
75813626
NCBI GeneID
23678
NCBI Accession #
NP_001028750.1
UniProt Primary Accession #
Q96BR1
UniProt Secondary Accession #
Q9P1Q7; Q9UKG5; A8K5W3; B3KQC2
UniProt Related Accession #
Q96BR1
GenBank Nucleotide #
NM_001033578.2
NCBI Official Full Name
serine/threonine-protein kinase Sgk3 isoform 1
NCBI Official Synonym Full Names
serum/glucocorticoid regulated kinase family member 3
NCBI Official Symbol
SGK3
NCBI Official Synonym Symbols
CISK; SGK2; SGKL
UniProt Protein Name
Serine/threonine-protein kinase Sgk3
UniProt Synonym Protein Names
Cytokine-independent survival kinase; Serum/glucocorticoid-regulated kinase 3; Serum/glucocorticoid-regulated kinase-like
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
SGK3
UniProt Synonym Gene Names
CISK; SGKL
NCBI Protein Information
serine/threonine-protein kinase Sgk3

NCBI Summary for SGK3

This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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UniProt Comments for SGK3

Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na+ channels: SCNN1A/ENAC and SCN5A, K+ channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca2+ channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na+/dicarboxylate cotransporter: SLC13A2/NADC1, Na+-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na+/H+ exchanger: SLC9A3/NHE3, and the Na+/K+ ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.
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Research Articles on SGK3

1. These findings highlight the importance of the hVps34-SGK3 pathway in counteracting inhibition of PI3K/Akt signalling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SGK3 recombinant protein

 Reference Product  PubMed Publications
 PDK1 recombinant protein  >16 publications with SGK3 and PDK1
 PDPK1 recombinant protein  >7 publications with SGK3 and PDPK1
 GSK3A recombinant protein  >1 publications with SGK3 and GSK3A
 GSK3B recombinant protein  >1 publications with SGK3 and GSK3B
 SLC9A3R2 recombinant protein  >1 publications with SGK3 and SLC9A3R2

Pathways associated with SGK3 recombinant protein

 Products by Pathway  Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Organs/Tissues associated with SGK3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >18 publications with SGK3 and Kidney
 Blood Antibodies  >12 publications with SGK3 and Blood
 Brain Antibodies  >12 publications with SGK3 and Brain
 Intestine Antibodies  >6 publications with SGK3 and Intestine
 Skin Antibodies  >6 publications with SGK3 and Skin
 Liver Antibodies  >4 publications with SGK3 and Liver
 Bone Antibodies  >4 publications with SGK3 and Bone
 Embryonic Tissue Antibodies  >3 publications with SGK3 and Embryonic Tissue
 Ear Antibodies  >3 publications with SGK3 and Ear
 Bone Marrow Antibodies  >2 publications with SGK3 and Bone Marrow
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