Human TSLPR Recombinant Protein – Cat# MBS146767

Thymic Stromal Lymphopoietin Receptor (TSLPR) Human Recombinant Protein

Name: TSLPR Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146767
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146767

Description: TSLPR Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 218 amino acids (23-231) and having a molecular mass of 25.2kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Thymic Stromal Lymphopoietin Receptor (TSLPR), Recombinant Protein

Full Product Name

Recombinant Human Thymic Stromal Lymphopoietin Receptor Sf9

Product Gene Name

TSLPR recombinant protein

Product Synonym Names

TSLPR Human, Sf9; Cytokine receptor-like factor 2; CRLF2; Cytokine receptor-like factor 2; Cytokine receptor-like 2; IL-XR; Thymic stromal lymphopoietin protein receptor; TSLP receptor; CRL2; ILXR; TSLPR; Cytokine receptor-like factor 2 isoform 1; CRLF2Y; Thymic Stromal Lymphopoietin Receptor Human Recombinant, Sf9

Sequence

ADPQGGAAEG VQIQIIYFNL ETVQVTWNAS KYSRTNLTFH YRFNGDEAYD QCTNYLLQEG HTSGCLLDAE QRDDILYFSI RNGTHPVFTA SRWMVYYLKP SSPKHVRFSW HQDAVTVTCS DLSYGDLLYE VQYRSPFDTE WQSKQENTCN VTIEGLDAEK CYSFWVRVKA MEDVYGPDTY PSDWSEVTCW QRGEIRDACA ETPTPPKPKL SKHHHHH H.

Host

Sf9, Baculovirus cells

Form/Format

Sterile filtered clear solution.
TSLPR protein solution (1mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Molecular Weight

29,360 Da

OMIM

AF142570 mRNA

3D Structure

ModBase 3D Structure for Q9HC73

Product Categories/Family for TSLPR recombinant protein

Cytokines and Growth Factors

Other Notes

Small volumes of TSLPR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TSLPR purchase

MBS146767 is a recombinant protein targeting TSLPR. Also known as Recombinant Human Thymic Stromal Lymphopoietin Receptor Sf9. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for TSLPR. It may not necessarily be applicable to this product.

NCBI GI #

589269166

NCBI GeneID

64109

NCBI Accession #

NP_001012288.2

UniProt Primary Accession #

Q9HC73

UniProt Secondary Accession #

Q5G7M1; Q9H5R3; J3QKD1

UniProt Related Accession #

Q9HC73

GenBank Nucleotide #

NM_001012288.2

NCBI Official Full Name

cytokine receptor-like factor 2 isoform 2

NCBI Official Synonym Full Names

cytokine receptor-like factor 2

NCBI Official Symbol

CRLF2

NCBI Official Synonym Symbols

CRL2; TSLPR; CRLF2Y

UniProt Protein Name

Cytokine receptor-like factor 2

UniProt Synonym Protein Names

Cytokine receptor-like 2; IL-XR; Thymic stromal lymphopoietin protein receptor; TSLP receptor

UniProt Gene Name

CRLF2

UniProt Synonym Gene Names

CRL2; ILXR; TSLPR; TSLP receptor

NCBI Protein Information

cytokine receptor-like factor 2

NCBI Summary for TSLPR

This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

UniProt Comments for TSLPR

CRLF2: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22.33 and Yp11.2

Research Articles on TSLPR

1. In adult B-cell acute lymphoblastic leukemia without recurrent fusion genes , high CRLF2 expression is associated with distinct clinico-biological features and an unfavourable prognosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TSLPR recombinant protein

Reference Product	PubMed Publications
TSLP recombinant protein	>62 publications with TSLPR and TSLP
JAK2 recombinant protein	>36 publications with TSLPR and JAK2
JAK1 recombinant protein	>11 publications with TSLPR and JAK1
IL7R recombinant protein	>9 publications with TSLPR and IL7R
PTPN6 recombinant protein	>1 publications with TSLPR and PTPN6
TYK2 recombinant protein	>1 publications with TSLPR and TYK2
JAK3 recombinant protein	>1 publications with TSLPR and JAK3

Pathways associated with TSLPR recombinant protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
TSLP Signaling Pathway antibodies	TSLP Signaling Pathway Diagram

Diseases associated with TSLPR recombinant protein

Disease Name	Pubmed Publications
Precursor Cell Lymphoblastic Leukemia-Lymphoma Antibodies	>62 publications with TSLPR and Precursor Cell Lymphoblastic Leukemia-Lymphoma
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Antibodies	>39 publications with TSLPR and Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Inflammation Antibodies	>29 publications with TSLPR and Inflammation
Nervous System Diseases Antibodies	>11 publications with TSLPR and Nervous System Diseases
Necrosis Antibodies	>9 publications with TSLPR and Necrosis
Cell Transformation, Neoplastic Antibodies	>5 publications with TSLPR and Cell Transformation, Neoplastic
Disease Models, Animal Antibodies	>5 publications with TSLPR and Disease Models, Animal
Death Antibodies	>2 publications with TSLPR and Death
Fibrosis Antibodies	>2 publications with TSLPR and Fibrosis
Lung Injury Antibodies	>1 publications with TSLPR and Lung Injury