Human MMP14 Recombinant Protein – Cat# MBS146774

Matrix Metalloproteinase-14 (MMP14) Human Recombinant Protein

Name: MMP14 Recombinant Protein; Matrix Metalloproteinase-14; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146774
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146774

Description: MMP14 Human Recombinant produced in Sf9 Baculovirus cells is a single, non-glycosylated polypeptide chain containing 527 amino acids (21-538a.a) and having a molecular mass of 59.9kDa. (Molecular size on SDS-PAGE will appear at approximately… More details

$250 / 0.001 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Matrix Metalloproteinase-14 (MMP14), Recombinant Protein

Full Product Name

Recombinant Human Matrix Metalloproteinase-14

Product Gene Name

MMP14 recombinant protein

Product Synonym Names

MMP14 Human; Matrix Metallopeptidase 14; Matrix Metallopeptidase 14 (Membrane-Inserted); Membrane-Type-1 Matrix Metalloproteinase; Membrane Type 1 Metalloprotease; EC 3.4.24.80; MT-MMP 1; MT1-MMP; MMP-14; MMP-X1; MT1MMP; MTMMP1; Matrix Metalloproteinase 14 (Membrane-Inserted); Membrane-Type Matrix Metalloproteinase 1; Matrix Metalloproteinase-14; EC 3.4.24; MT-MMP; WNCHRS; Matrix metalloproteinase-14; Membrane-type matrix metalloproteinase 1; Matrix Metalloproteinase-14 Human Recombinant

Sequence

ADL ALASLGSAQS SSFSPEA WLQQYGYLPP GDLRTHTQRS PQSLSAAIAA MQKFYGLQVT GKADADTMKA MRRPRCGVPD KFGAEIKANV RRKRYAIQGL KWQHNEITFC IQNYTPKVGE YATYEAIRKA FRVWESATPL RFREVPYAYI REGHEKQADI MIFFAEGFHG DSTPFDGEGG FLAHAYFPGP NIGGDTHFDS AEPWTVRNED LNGNDIFLVA VHELGHALGL EHSSDPSAIM APFYQWMDTE NFVLPDDDRR GIQQLYGGES GFPTKMPPQP RTTSRPSVPD KPKNPTYGPN ICDGNFDTVA MLRGEMFVFK ERWFWRVRNN QVMDGYPMPI GQFWRGLPAS INTAYERKDG KFVFFKGDKH WVFDEASLEP GYPKHIKELG RGLPTDKIDA ALFWMPNGKT YFFRGNKYYR FNEELRAVDS EYPKNIKVWE GIPESPRGSF MGSDEVFTYF YKGNKYWKFN NQKLKVEPGY PKSALRDWMG CPSGGRPDEG TEEETEVIII EVDEEGGGAV SHHHHHH .

Host

Sf9, Baculovirus cells

Form/Format

Sterile filtered colorless solution.
MMP14 protein solution (0.25mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

Purity/Purification

Greater than 90% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Molecular Weight

65,894 Da

OMIM

D26512 mRNA

3D Structure

ModBase 3D Structure for P50281

Product Categories/Family for MMP14 recombinant protein

Enzymes

Other Notes

Small volumes of MMP14 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MMP14 purchase

MBS146774 is a recombinant protein targeting MMP14. Also known as Recombinant Human Matrix Metalloproteinase-14. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP14. It may not necessarily be applicable to this product.

NCBI GI #

4826834

NCBI GeneID

4323

NCBI Accession #

NP_004986.1

UniProt Primary Accession #

P50281

UniProt Secondary Accession #

Q6GSF3; Q92678; A8K5L0

UniProt Related Accession #

P50281

GenBank Nucleotide #

NM_004995.3

NCBI Official Full Name

matrix metalloproteinase-14 preproprotein

NCBI Official Synonym Full Names

matrix metallopeptidase 14

NCBI Official Symbol

MMP14

NCBI Official Synonym Symbols

MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1

UniProt Protein Name

Matrix metalloproteinase-14

UniProt Synonym Protein Names

MMP-X1; Membrane-type matrix metalloproteinase 1; MT-MMP 1; MTMMP1; Membrane-type-1 matrix metalloproteinase; MT1-MMP; MT1MMP

Protein Family

Matrix metalloproteinase

UniProt Gene Name

MMP14

UniProt Synonym Gene Names

MMP-14; MT-MMP 1; MTMMP1; MT1-MMP; MT1MMP

NCBI Protein Information

matrix metalloproteinase-14

NCBI Summary for MMP14

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]

UniProt Comments for MMP14

Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.

Research Articles on MMP14

1. possible involvement of membrane-type 1 matrix metalloproteinase processing of erythropoietin-producing hepatocellular receptor-2in invasiveness of cutaneous cutaneous squamous cell carcinoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MMP14 recombinant protein

Reference Product	PubMed Publications
MMP2 recombinant protein	>118 publications with MMP14 and MMP2
MMP13 recombinant protein	>45 publications with MMP14 and MMP13
TIMP2 recombinant protein	>26 publications with MMP14 and TIMP2
TIMP3 recombinant protein	>10 publications with MMP14 and TIMP3
TIMP4 recombinant protein	>5 publications with MMP14 and TIMP4
CLDN1 recombinant protein	>3 publications with MMP14 and CLDN1
LRP1 recombinant protein	>2 publications with MMP14 and LRP1
CCL7 recombinant protein	>2 publications with MMP14 and CCL7
CAV1 recombinant protein	>2 publications with MMP14 and CAV1
ACAN recombinant protein	>1 publications with MMP14 and ACAN

Pathways associated with MMP14 recombinant protein

Products by Pathway	Pathway Diagram
AGE/RAGE Pathway antibodies	AGE/RAGE Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Degradation Of Collagen Pathway antibodies	Degradation Of Collagen Pathway Diagram
Degradation Of Collagen Pathway antibodies	Degradation Of Collagen Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
GnRH Signaling Pathway antibodies	GnRH Signaling Pathway Diagram
GnRH Signaling Pathway antibodies	GnRH Signaling Pathway Diagram

Diseases associated with MMP14 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>231 publications with MMP14 and Neoplasms
Neoplasm Invasiveness Antibodies	>95 publications with MMP14 and Neoplasm Invasiveness
Neoplasm Metastasis Antibodies	>73 publications with MMP14 and Neoplasm Metastasis
Breast Neoplasms Antibodies	>51 publications with MMP14 and Breast Neoplasms
Adenocarcinoma Antibodies	>43 publications with MMP14 and Adenocarcinoma
Cardiovascular Diseases Antibodies	>31 publications with MMP14 and Cardiovascular Diseases
Inflammation Antibodies	>30 publications with MMP14 and Inflammation
Lung Neoplasms Antibodies	>21 publications with MMP14 and Lung Neoplasms
Fibrosis Antibodies	>18 publications with MMP14 and Fibrosis
Liver Neoplasms Antibodies	>18 publications with MMP14 and Liver Neoplasms

Organs/Tissues associated with MMP14 recombinant protein

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>84 publications with MMP14 and Vascular
Blood Antibodies	>77 publications with MMP14 and Blood
Bone Antibodies	>54 publications with MMP14 and Bone
Lung Antibodies	>46 publications with MMP14 and Lung
Muscle Antibodies	>38 publications with MMP14 and Muscle
Embryonic Tissue Antibodies	>31 publications with MMP14 and Embryonic Tissue
Connective Tissue Antibodies	>29 publications with MMP14 and Connective Tissue
Brain Antibodies	>24 publications with MMP14 and Brain
Skin Antibodies	>21 publications with MMP14 and Skin
Mouth Antibodies	>20 publications with MMP14 and Mouth