Mouse GLO1 Active Protein – Cat# MBS146801

Glyoxalase-I (GLO1) Mouse Active Protein

Name: GLO1 Active Protein; Glyoxalase-I; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS146801
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146801

Description: GLO1 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 192 amino acids (1-184a.a.) and having a molecular mass of 21.8kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Glyoxalase-I (GLO1), Active Protein

Full Product Name

Recombinant Mouse Glyoxalase-I

Product Gene Name

GLO1 active protein

Product Synonym Names

GLO1 Mouse; Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; Glyoxalase-I Mouse Recombinant

Sequence

MAEPQPASSG LTDETAFSCC SDPDPSTKDF LLQQTMLRIK DPKKSLDFYT RVLGLTLLQK LDFPAMKFSL YFLAYEDKND IPKDKSEKTA WTFSRKATLE LTHNWGTEDD ETQSYHNGNS DPRGFGHIGI AVPDVYSACK RFEELGVKFV KKPDDGKMKG LAFIQDPDGY WIEILNPNKI ATIILEH HHH HH

Host

Sf9, Baculovirus cells

Form/Format

Sterile filtered colorless solution.
GLO1 protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Molecular Weight

20,810 Da

3D Structure

ModBase 3D Structure for Q9CPU0

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity is > 210 units/mg, and is defined as the amount of enzyme that will form 1.0 umol of S-lactoylglutathione from methylglyoxal and reduced glutathione per minute at pH 6.5 at 25C.

Product Categories/Family for GLO1 active protein

Enzymes

Other Notes

Small volumes of GLO1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GLO1 purchase

MBS146801 is an active protein targeting GLO1. Also known as Recombinant Mouse Glyoxalase-I. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for GLO1. It may not necessarily be applicable to this product.

NCBI GI #

165932333

NCBI GeneID

109801

NCBI Accession #

NP_001107032.1

UniProt Primary Accession #

Q9CPU0

UniProt Secondary Accession #

Q543L3; Q8R3T1

UniProt Related Accession #

Q9CPU0

GenBank Nucleotide #

NM_001113560.1

NCBI Official Full Name

lactoylglutathione lyase

NCBI Official Synonym Full Names

glyoxalase 1

NCBI Official Symbol

Glo1

NCBI Official Synonym Symbols

GLY1; Qglo; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s; AW550643; 0610009E22Rik; 1110008E19Rik; 2510049H23Rik

UniProt Protein Name

Lactoylglutathione lyase

UniProt Synonym Protein Names

Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase

Protein Family

Lactoylglutathione lyase

UniProt Gene Name

Glo1

UniProt Synonym Gene Names

Glx I

NCBI Protein Information

lactoylglutathione lyase

UniProt Comments for GLO1

GLO1: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Belongs to the glyoxalase I family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - pyruvate; EC 4.4.1.5; Lyase

Chromosomal Location of Human Ortholog: 17 A3.3|17 15.69 cM

Molecular Function: lactoylglutathione lyase activity; zinc ion binding

Biological Process: carbohydrate metabolic process; glutathione metabolic process; methylglyoxal catabolic process to D-lactate; methylglyoxal metabolic process; negative regulation of apoptosis; osteoclast differentiation; regulation of transcription from RNA polymerase II promoter

Research Articles on GLO1

1. Glo1 knockdown does not have major short term effects on the energy expenditure or the formation of atherosclerotic plaques.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with GLO1 active protein

Products by Pathway	Pathway Diagram
Pyruvate Metabolism Pathway antibodies	Pyruvate Metabolism Pathway Diagram
Pyruvate Metabolism Pathway antibodies	Pyruvate Metabolism Pathway Diagram
Methylglyoxal Degradation I Pathway antibodies	Methylglyoxal Degradation I Pathway Diagram

Diseases associated with GLO1 active protein

Disease Name	Pubmed Publications
Mental Disorders Antibodies	>17 publications with GLO1 and Mental Disorders
Neoplasms Antibodies	>16 publications with GLO1 and Neoplasms
Nervous System Diseases Antibodies	>10 publications with GLO1 and Nervous System Diseases
Lung Diseases Antibodies	>8 publications with GLO1 and Lung Diseases
Anxiety Disorders Antibodies	>8 publications with GLO1 and Anxiety Disorders
Carcinoma Antibodies	>6 publications with GLO1 and Carcinoma
Cardiovascular Diseases Antibodies	>6 publications with GLO1 and Cardiovascular Diseases
Drug Toxicity Antibodies	>6 publications with GLO1 and Drug Toxicity
Necrosis Antibodies	>5 publications with GLO1 and Necrosis
Autistic Disorder Antibodies	>5 publications with GLO1 and Autistic Disorder

Organs/Tissues associated with GLO1 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>122 publications with GLO1 and Blood
Brain Antibodies	>14 publications with GLO1 and Brain
Liver Antibodies	>8 publications with GLO1 and Liver
Lung Antibodies	>6 publications with GLO1 and Lung
Kidney Antibodies	>6 publications with GLO1 and Kidney
Prostate Antibodies	>3 publications with GLO1 and Prostate
Bone Antibodies	>3 publications with GLO1 and Bone
Joint Antibodies	>2 publications with GLO1 and Joint
Bladder Antibodies	>2 publications with GLO1 and Bladder
Intestine Antibodies	>2 publications with GLO1 and Intestine