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Folate Hydrolase 1 (FOLH1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146805

Description: FOLH1 Mouse Recombinant produced in in Sf9 Baculovirus cells is a single, non-glycosylated polypeptide chain containing 717 amino acids (45-752a.a) and having a molecular mass of 80.5kDa (Migrates at 70-100kDa on SDS-PAGE under reducing… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Folate Hydrolase 1 (FOLH1), Recombinant Protein
Full Product Name
Recombinant Mouse Folate Hydrolase 1
Product Gene Name
FOLH1 recombinant protein
Product Synonym Names
FOLH1 Mouse; Folh1; GCP2; mopsm; Glutamate carboxypeptidase 2; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; FGCP; Glutamate carboxypeptidase II; GCPII; Naalad1; Folate Hydrolase 1 Mouse Recombinant
Sequence
ADPKPSNEAT GNVSHSGMKK EFLHELKAEN IKKFLYNFTR TPHLAGTQNN FELAKQIHDQ WKEFGLDLVE LSHYDVLLSY PNKTHPNYIS IINEDGNEIF KTSLSEQPPP GYENISDVVP PYSAFSPQGT PEGDLVYVNY ARTEDFFKLE REMKISCSGK IVIARYGKVF RGNMVKNAQL AGAKGMILYS DPADYFVPAV KSYPDGWNLP GGGVQRGNVL NLNGAGDPLT PGYPANEHAY RHELTNAVGL PSIPVHPIGY DDAQKLLEHM GGPAPPDSSW KGGLKVPYNV GPGFAGNFST QKVKMHIHSY TKVTRIYNVI GTLKGALEPD RYVILGGHRD AWVFGGIDPQ SGAAVVHEIV RSFGTLKKKG RRPRRTILFA SWDAEEFGLL GSTEWAEEHS RLLQERGVAY INADSSIEGN YTLRVDCTPL MYSLVYNLTK ELQSPDEGFE GKSLYDSWKE KSPSPEFIGM PRISKLGSGN DFEVFFQRLG IASGRARYTK NWKTNKVSSY PLYHSVYETY ELVVKFYDPT FKYHLTVAQV RGAMVFELAN SIVLPFDCQS YAVALKKYAD TIYNISMKHP QEMKAYMISF DSLFSAVNNF TDVASKFNQR LQELDKSNPI LLRIMNDQLM YLERAFIDPL GLPGRPFYRH IIYAPSSHNK YAGESFPGIY DALFDISSKV NASKAWNEVK RQISIATFTV QAAAETLREV AHHHHHH
Host
Sf9, Baculovirus cells
Form/Format
Sterile filtered colorless solution.
The FOLH1 solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Purity/Purification
Greater than 85% as determined by SDS-PAGE.
Molecular Weight
84,574 Da
3D Structure
ModBase 3D Structure for O35409

Product Categories/Family for FOLH1 recombinant protein

Enzymes

Other Notes

Small volumes of FOLH1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FOLH1 purchase

MBS146805 is a recombinant protein targeting FOLH1. Also known as Recombinant Mouse Folate Hydrolase 1. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for FOLH1. It may not necessarily be applicable to this product.

NCBI GI #
228008369
NCBI GeneID
53320
NCBI Accession #
NP_001153178.1
UniProt Primary Accession #
O35409
UniProt Secondary Accession #
Q0VDM5; Q9DCC2
UniProt Related Accession #
O35409
GenBank Nucleotide #
NM_001159706.1
NCBI Official Full Name
glutamate carboxypeptidase 2 isoform 2
NCBI Official Synonym Full Names
folate hydrolase 1
NCBI Official Symbol
Folh1
NCBI Official Synonym Symbols
GCP2; mopsm
UniProt Protein Name
Glutamate carboxypeptidase 2
UniProt Synonym Protein Names
Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; FGCP; Glutamate carboxypeptidase II; GCPII; Membrane glutamate carboxypeptidase; mGCP; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; Prostate-specific membrane antigen homolog; Pteroylpoly-gamma-glutamate carboxypeptidase
Protein Family
Glutamate carboxypeptidase
UniProt Gene Name
Folh1
UniProt Synonym Gene Names
Mopsm; Naalad1; FGCP; GCPII; mGCP; NAALADase I
NCBI Protein Information
glutamate carboxypeptidase 2

UniProt Comments for FOLH1

FOLH1: Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Belongs to the peptidase M28 family. M28B subfamily. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.17.21; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 7|7 D3

Cellular Component: integral to membrane; integral to plasma membrane

Molecular Function: carboxypeptidase activity; dipeptidase activity; peptidase activity

Biological Process: folic acid and derivative metabolic process; positive regulation of apoptosis; proteolysis
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Research Articles on FOLH1

1. Data support the hypothesis that the neuroprotective efficacy of glutamate carboxypeptidase II knockout in traumatic brain injury is mediated via a reduction in oxidative stress.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with FOLH1 recombinant protein

 Products by Pathway  Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 One Carbon Metabolism Pathway antibodies  One Carbon Metabolism Pathway Diagram
 Vitamin Digestion And Absorption Pathway antibodies  Vitamin Digestion And Absorption Pathway Diagram
 Vitamin Digestion And Absorption Pathway antibodies  Vitamin Digestion And Absorption Pathway Diagram
 Glutamate Removal From Folates Pathway antibodies  Glutamate Removal From Folates Pathway Diagram
 Glutathione-mediated Detoxification Pathway antibodies  Glutathione-mediated Detoxification Pathway Diagram

Diseases associated with FOLH1 recombinant protein

 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >9 publications with FOLH1 and Prostatic Neoplasms
 Brain Diseases Antibodies  >3 publications with FOLH1 and Brain Diseases
 Heart Diseases Antibodies  >2 publications with FOLH1 and Heart Diseases
 Nervous System Diseases Antibodies  >2 publications with FOLH1 and Nervous System Diseases
 Death Antibodies  >2 publications with FOLH1 and Death
 Lung Neoplasms Antibodies  >2 publications with FOLH1 and Lung Neoplasms
 Necrosis Antibodies  >2 publications with FOLH1 and Necrosis
 Musculoskeletal Diseases Antibodies  >1 publications with FOLH1 and Musculoskeletal Diseases
 Nerve Degeneration Antibodies  >1 publications with FOLH1 and Nerve Degeneration
 Hypertension Antibodies  >1 publications with FOLH1 and Hypertension

Organs/Tissues associated with FOLH1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10 publications with FOLH1 and Blood
 Brain Antibodies  >7 publications with FOLH1 and Brain
 Kidney Antibodies  >4 publications with FOLH1 and Kidney
 Eye Antibodies  >2 publications with FOLH1 and Eye
 Liver Antibodies  >1 publications with FOLH1 and Liver
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