Human GZMH Recombinant Protein – Cat# MBS146809

Granzyme-H (GZMH) Human Recombinant Protein

Name: GZMH Recombinant Protein; Granzyme-H; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146809
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146809

Description: GZMH produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 234 amino acids (19-246 a.a.) and having a molecular mass of 26.2kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). GZMH is… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Granzyme-H (GZMH), Recombinant Protein

Full Product Name

Recombinant Human Granzyme-H, Sf9

Product Gene Name

GZMH recombinant protein

Product Synonym Names

GZMH Human, sf9; Granzyme H; Granzyme H (Cathepsin G-Like 2; Protein H-CCPX); Cytotoxic T-Lymphocyte Proteinase; Cathepsin G-Like 2; CTSGL2; CCP-X; CSP-C; Cytotoxic T-Lymphocyte-Associated Serine Esterase 1; Cathepsin G-Like 2; Protein H-CCPX; Cytotoxin Serine Protease-C; Cytotoxic Serine Protease C; Protein H-CCPX; EC 3.4.21.79; EC 3.4.21; EC 3.4.21; CTLA1; CGL-2; CGL2; Granzyme-H Human Recombinant, sf9

Sequence

EEIIGGHEAK PHSRPYMAFV QFLQEKSRKR CGGILVRKDF VLTAAHCQGS SINVTLGAHN IKEQERTQQF IPVKRPIPHP AYNPKNFSND IMLLQLERKA KWTTAVRPLR LPSSKAQVKP GQLCSVAGWG YVSMSTLATT LQEVLLTVQK DCQCERLFHG NYSRATEICV GDPKKTQTGF KGDSGGPLVC KDVAQGILSY GNKKGTPPGV YIKVSHFLPW IKRTMKRLHH HHHH

Host

Sf9, Baculovirus cells

Form/Format

Sterile filtered colorless solution.
GZMH protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Molecular Weight

12,609 Da

OMIM

J02907 Genomic DNA

3D Structure

ModBase 3D Structure for P20718

Product Categories/Family for GZMH recombinant protein

Enzymes

Other Notes

Small volumes of GZMH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GZMH purchase

MBS146809 is a recombinant protein targeting GZMH. Also known as Recombinant Human Granzyme-H, Sf9. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for GZMH. It may not necessarily be applicable to this product.

NCBI GI #

399124767

NCBI GeneID

2999

NCBI Accession #

NP_001257710.1

UniProt Primary Accession #

P20718

UniProt Secondary Accession #

Q6XGZ0; Q6XGZ1; G3V2C5

UniProt Related Accession #

P20718

GenBank Nucleotide #

NM_001270781.1

NCBI Official Full Name

granzyme H isoform 3

NCBI Official Synonym Full Names

granzyme H

NCBI Official Symbol

GZMH

NCBI Official Synonym Symbols

CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2

UniProt Protein Name

Granzyme H

UniProt Synonym Protein Names

CCP-X; Cathepsin G-like 2; CTSGL2; Cytotoxic T-lymphocyte proteinase; Cytotoxic serine protease C; CSP-C

Protein Family

Granzyme

UniProt Gene Name

GZMH

UniProt Synonym Gene Names

CGL2; CTSGL2; CTSGL2; CSP-C

NCBI Protein Information

granzyme H

NCBI Summary for GZMH

This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015]

UniProt Comments for GZMH

GZMF: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Belongs to the peptidase S1 family. Granzyme subfamily.

Protein type: EC 3.4.21.-; Protease

Chromosomal Location of Human Ortholog: 14q12

Cellular Component: cytoplasm; intracellular membrane-bound organelle; membrane

Molecular Function: serine-type endopeptidase activity

Biological Process: immune response; protein processing

Research Articles on GZMH

1. Granzyme H did directly process DFF45, potentially leading to DNA damage.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with GZMH recombinant protein

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Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies	Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
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Peptide Hormone Metabolism Pathway antibodies	Peptide Hormone Metabolism Pathway Diagram
Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies	Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram

Diseases associated with GZMH recombinant protein

Disease Name	Pubmed Publications
Death Antibodies	>8 publications with GZMH and Death
Carcinoma Antibodies	>1 publications with GZMH and Carcinoma
Necrosis Antibodies	>1 publications with GZMH and Necrosis
Inflammation Antibodies	>1 publications with GZMH and Inflammation

Organs/Tissues associated with GZMH recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>17 publications with GZMH and Blood