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Beta-1, 3-N-Acetylglucosaminyltransferase 2 (B3GNT2) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146820

Description: B3GNT2 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 375 amino acids (29-397a.a.) and having a molecular mass of 43.5kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa). B3GNT2 is… More details

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Product Overview

Online Datasheet in PDF
Product Name
Beta-1, 3-N-Acetylglucosaminyltransferase 2 (B3GNT2), Recombinant Protein
Full Product Name
Recombinant Human Beta-1,3-N-Acetylglucosaminyltransferase 2
Product Gene Name
B3GNT2 recombinant protein
Product Synonym Names
B3GNT2 Human; B3GNT2; B3GN-T2; B3GNT; B3GNT-2; B3GNT1; BETA3GNT; BGnT-2; BGNT2; N-acetyllactosaminide beta-1, 3-N-acetylglucosaminyltransferase 2; Beta-1, 3-N-acetylglucosaminyltransferase 1; BGnT-1; Beta-1, 3-Gn-T1; Beta3Gn-T1; Beta-1, 3-galactosyltransferase 7; Beta-1, 3-GalTase 7; Beta3Gal-T7; Beta3GalT7; b3Gal-T7; Beta-3-Gx-T7; beta-GlcNAc beta-1, 3-galactosyltransferase 7; betaGal beta-1, 3-N-acetylglucosaminyltransferase 2; BGnT-2; Beta-1, 3-Gn-T2; Beta-1, 3-N-acetylglucosaminyltransferase 2; Beta3Gn-T2; beta-N-acetylglucosamine beta-1, 3-galactosyltransferase 7; Beta-1, 3-N-Acetylglucosaminyltransferase 2 Human Recombinant
Sequence
ADP KSSSQEKNGK GEVIIPK EKFWKISTPP EAYWNREQEK LNRQYNPILS MLTNQTGEAG RLSNISHLNY CEPDLRVTSV VTGFNNLPDR FKDFLLYLRC RNYSLLIDQP DKCAKKPFLL LAIKSLTPHF ARRQAIRESW GQESNAGNQT VVRVFLLGQT PPEDNHPDLS DMLKFESEKH QDILMWNYRD TFFNLSLKEV LFLRWVSTSC PDTEFVFKGD DDVFVNTHHI LNYLNSLSKT KAKDLFIGDV IHNAGPHRDK KLKYYIPEVV YSGLYPPYAG GGGFLYSGHL ALRLYHITDQ VHLYPIDDVY TGMCLQKLGL VPEKHKGFRT FDIEEKNKNN ICSYVDLMLV HSRKPQEMID IWSQLQSAHL KCHHHHH H
Host
Sf9, Baculovirus cells
Form/Format
Sterile filtered colorless solution.
B3GNT2 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Molecular Weight
45,484 Da
OMIM
AF092051 mRNA
3D Structure
ModBase 3D Structure for Q9NY97

Product Categories/Family for B3GNT2 recombinant protein

Enzymes

Other Notes

Small volumes of B3GNT2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for B3GNT2 purchase

MBS146820 is a recombinant protein targeting B3GNT2. Also known as Recombinant Human Beta-1,3-N-Acetylglucosaminyltransferase 2. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for B3GNT2. It may not necessarily be applicable to this product.

NCBI GI #
977380204
NCBI GeneID
10678
NCBI Accession #
NP_001306004.1
UniProt Primary Accession #
Q9NY97
UniProt Secondary Accession #
Q54AC1; Q9NQQ9; Q9NQR0; Q9NUT9
UniProt Related Accession #
Q9NY97
GenBank Nucleotide #
NM_001319075.1
NCBI Official Full Name
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
NCBI Official Synonym Full Names
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
NCBI Official Symbol
B3GNT2
NCBI Official Synonym Symbols
B3GNT; BGNT2; B3GNT1; BGnT-2; beta-1; 3-Gn-T1; 3-Gn-T2; B3GN-T2; B3GNT-2; BETA3GNT; beta3Gn-T1; beta3Gn-T2
UniProt Protein Name
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
UniProt Synonym Protein Names
Beta-1,3-N-acetylglucosaminyltransferase 1; BGnT-1; Beta-1,3-Gn-T1; Beta3Gn-T1; Beta-1,3-galactosyltransferase 7; Beta-1,3-GalTase 7; Beta3Gal-T7; Beta3GalT7; b3Gal-T7; Beta-3-Gx-T7; UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 7; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2; BGnT-2; Beta-1,3-Gn-T2; Beta-1,3-N-acetylglucosaminyltransferase 2; Beta3Gn-T2; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 7
Protein Family
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
UniProt Gene Name
B3GNT2
UniProt Synonym Gene Names
B3GALT7; B3GNT1; BGnT-1; Beta-1,3-Gn-T1; Beta3Gn-T1; Beta-1,3-GalTase 7; Beta3Gal-T7; Beta3GalT7; b3Gal-T7; BGnT-2; Beta-1,3-Gn-T2; Beta-1,3-N-acetylglucosaminyltransferase 2; Beta3Gn-T2
NCBI Protein Information
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

NCBI Summary for B3GNT2

This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2016]
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UniProt Comments for B3GNT2

B3GNT2: Catalyzes the initiation and elongation of poly-N- acetyllactosamine chains. Belongs to the glycosyltransferase 31 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; EC 2.4.1.-; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; Glycan Metabolism - keratan sulfate biosynthesis; Membrane protein, integral; Motility/polarity/chemotaxis; Transferase

Chromosomal Location of Human Ortholog: 2p15

Cellular Component: Golgi membrane

Molecular Function: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

Biological Process: keratan sulfate biosynthetic process; O-glycan processing; poly-N-acetyllactosamine biosynthetic process
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Research Articles on B3GNT2

1. Study provides evidence that mutations in B3GNT2, B4GALT2, and ST6GALNAC2 underlie aberrant glycosylation, and contribute to the pathogenesis of molecular subsets of colon and other gastrointestinal malignancies.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with B3GNT2 recombinant protein

 Reference Product  PubMed Publications
 B4GALT1 recombinant protein  >1 publications with B3GNT2 and B4GALT1
 B4GALT2 recombinant protein  >1 publications with B3GNT2 and B4GALT2

Pathways associated with B3GNT2 recombinant protein

 Products by Pathway  Pathway Diagram
 Glycosaminoglycan Biosynthesis - Keratan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Keratan Sulfate Pathway Diagram
 Glycosaminoglycan Biosynthesis - Keratan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Keratan Sulfate Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway antibodies  Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway Diagram
 Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway antibodies  Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway Diagram
 Keratan Sulfate Biosynthesis Pathway antibodies  Keratan Sulfate Biosynthesis Pathway Diagram
 Keratan Sulfate/keratin Metabolism Pathway antibodies  Keratan Sulfate/keratin Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram

Diseases associated with B3GNT2 recombinant protein

 Disease Name  Pubmed Publications
 Arthritis, Rheumatoid Antibodies  >3 publications with B3GNT2 and Arthritis, Rheumatoid
 Graves Disease Antibodies  >2 publications with B3GNT2 and Graves Disease
 Carcinoma, Hepatocellular Antibodies  >1 publications with B3GNT2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with B3GNT2 and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with B3GNT2 and Liver Diseases
 Inflammation Antibodies  >1 publications with B3GNT2 and Inflammation

Organs/Tissues associated with B3GNT2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with B3GNT2 and Brain
 Blood Antibodies  >2 publications with B3GNT2 and Blood
 Stomach Antibodies  >1 publications with B3GNT2 and Stomach
 Trachea Antibodies  >1 publications with B3GNT2 and Trachea
 Placenta Antibodies  >1 publications with B3GNT2 and Placenta
 Bladder Antibodies  >1 publications with B3GNT2 and Bladder
 Liver Antibodies  >1 publications with B3GNT2 and Liver
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