Human GDA Active Protein – Cat# MBS146829

Guanine Deaminase (GDA) Human Active Protein

Name: GDA Active Protein; Guanine Deaminase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146829
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146829

Description: GDA Human Recombinant produced in E Coli is a single polypeptide chain containing 477 amino acids (1-454) and having a molecular mass of 53kDa.GDA is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Guanine Deaminase (GDA), Active Protein

Full Product Name

Recombinant Human Guanine Deaminase, Active

Product Gene Name

GDA active protein

Product Synonym Names

GDA Human, Active; Guanine Deaminase; Guanine Aminohydrolase; Guanine Aminase; P51-Nedasin; EC 3.5.4.3; GUANASE; GAH; Cytoplasmic PSD95 Interactor; KIAA1258; NEDASIN; CYPIN; Guanine Deaminase Human Recombinant, Active

Sequence

MGSSHHH HHH SSGLVPRGSH MGSMCA AQMP PLAHIFRGTF VHSTWTCPME VLRDHLLGVS DSGKIVFLEE ASQQEKLAKE WCFKPCEIRE LSHHEFFMPG LVDTHIHASQ YSFAGSSIDL PLLEWLTKYT FPAEHRFQNI DFAEEVYTRV VRRTLKNGTT TACYFATIHT DSSLLLADIT DKFGQRAFVG KVCMDLNDTF PEYKETTEES IKETERFVSE MLQKNYSRVK PIVTPRFSLS CSETLMGELG NIAKTRDLHI QSHISENRDE VEAVKNLYPS YKNYTSVYDK NNLLTNKTVM AHGCYLSAEE LNVFHERGAS IAHCPNSNLS LSSGFLNVLE VLKHEVKIGL GTDVAGGYSY SMLDAIRRAV MVSNILLINK VNEKSLTLKE VFRLATLGGS QALGLDGEIG NFEVGKEFDA ILINPKASDS PIDLFYGDFF GDISEAVIQK FLYLGDDRNI EEVYVGGKQV VPFSSSV

Host

E Coli

Form/Format

GDA protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 0.15M NaCl, 10% glycerol, 1mM DTT.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

OMIM

AF095286 mRNA

3D Structure

ModBase 3D Structure for Q9Y2T3

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity is > 2, 000 pmol/min/ug, and is defined as the amount of enzyme that convert guanine to xanthine per minute at pH 8.0 at 37C.

Physical Appearance

Sterile filtered colorless solution.

Product Categories/Family for GDA active protein

Enzymes

Other Notes

Small volumes of GDA active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDA purchase

MBS146829 is an active protein targeting GDA. Also known as Recombinant Human Guanine Deaminase, Active. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GDA. It may not necessarily be applicable to this product.

NCBI GI #

335335014

NCBI GeneID

9615

NCBI Accession #

NP_001229434.1

UniProt Primary Accession #

Q9Y2T3

UniProt Secondary Accession #

Q5SZC7; Q9H335; Q9ULG2; B4DTY5

UniProt Related Accession #

Q9Y2T3

GenBank Nucleotide #

NM_001242505.2

NCBI Official Full Name

guanine deaminase isoform a

NCBI Official Synonym Full Names

guanine deaminase

NCBI Official Symbol

GDA

NCBI Official Synonym Symbols

CYPIN; GUANASE; NEDASIN

UniProt Protein Name

Guanine deaminase

UniProt Synonym Protein Names

Guanine aminohydrolase; GAH; p51-nedasin

Protein Family

Guanine deaminase

UniProt Gene Name

GDA

UniProt Synonym Gene Names

KIAA1258; Guanase; Guanine aminase; GAH

NCBI Protein Information

guanine deaminase

NCBI Summary for GDA

This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

UniProt Comments for GDA

GDA: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. Belongs to the ATZ/TRZ family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.5.4.3; Hydrolase; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 9q21.13

Cellular Component: cytosol; intracellular

Molecular Function: guanine deaminase activity

Biological Process: guanine metabolic process; nervous system development; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; purine nucleotide catabolic process

Research Articles on GDA

1. This protein has been found differentially expressed in thalami from patients with schizophrenia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GDA active protein

Reference Product	PubMed Publications
ADA active protein	>4 publications with GDA and ADA
PNP active protein	>3 publications with GDA and PNP
XDH active protein	>2 publications with GDA and XDH
HPRT1 active protein	>1 publications with GDA and HPRT1

Pathways associated with GDA active protein

Products by Pathway	Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Nucleotides Pathway antibodies	Metabolism Of Nucleotides Pathway Diagram
Purine Catabolism Pathway antibodies	Purine Catabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Guanosine Nucleotides Degradation Pathway antibodies	Guanosine Nucleotides Degradation Pathway Diagram
Guanosine Nucleotides Degradation III Pathway antibodies	Guanosine Nucleotides Degradation III Pathway Diagram
Purine Nucleotides Degradation Pathway antibodies	Purine Nucleotides Degradation Pathway Diagram

Diseases associated with GDA active protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>222 publications with GDA and Cardiovascular Diseases
Kidney Diseases Antibodies	>113 publications with GDA and Kidney Diseases
Heart Diseases Antibodies	>111 publications with GDA and Heart Diseases
Carcinoma Antibodies	>106 publications with GDA and Carcinoma
Liver Diseases Antibodies	>82 publications with GDA and Liver Diseases
Hypertension Antibodies	>72 publications with GDA and Hypertension
Necrosis Antibodies	>65 publications with GDA and Necrosis
Renal Insufficiency Antibodies	>61 publications with GDA and Renal Insufficiency
Disease Models, Animal Antibodies	>47 publications with GDA and Disease Models, Animal
Inflammation Antibodies	>47 publications with GDA and Inflammation

Organs/Tissues associated with GDA active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>207 publications with GDA and Brain
Liver Antibodies	>180 publications with GDA and Liver
Muscle Antibodies	>163 publications with GDA and Muscle
Kidney Antibodies	>157 publications with GDA and Kidney
Bone Antibodies	>132 publications with GDA and Bone
Lung Antibodies	>76 publications with GDA and Lung
Intestine Antibodies	>73 publications with GDA and Intestine
Pancreas Antibodies	>51 publications with GDA and Pancreas
Uterus Antibodies	>45 publications with GDA and Uterus
Mouth Antibodies	>36 publications with GDA and Mouth