Human MGLL Active Protein – Cat# MBS146830

Monoglyceride Lipase (MGLL) Human Active Protein

Name: MGLL Active Protein; Monoglyceride Lipase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146830
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146830

Description: MGLL Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 333 amino acids (1-313 a.a.) and having a molecular mass of 36.4kDa. The MGLL is purified by… More details

$250 / 0.001 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Monoglyceride Lipase (MGLL), Active Protein

Full Product Name

Recombinant Human Monoglyceride Lipase, Active

Product Gene Name

MGLL active protein

Product Synonym Names

MGLL Human, Active; Monoglyceride lipase; MGL; HU-K5; Lysophospholipase homolog; Lysophospholipase-like; Monoacylglycerol lipase; MAGL; MGLL; HUK5; Monoglyceride Lipase Human Recombinant, Active

Sequence

MGSSHHH HHH SSGLVPRGSH METGPE DPSS MPEESSPRRT PQSIPYQDLP HLVNADGQYL FCRYWKPTGT PKALIFVSHG AGEHSGRYEE LARMLMGLDL LVFAHDHVGH GQSEGERMVV SDFHVFVRDV LQHVDSMQKD YPGLPVFLLG HSMGGAIAIL TAAERPGHFA GMVLISPLVL ANPESATTFK VLAAKVLNLV LPNLSLGPID SSVLSRNKTE VDIYNSDPLI CRAGLKVCFG IQLLNAVSRV ERALPKLTVP FLLLQGSADR LCDSKGAYLL MELAKSQDKT LKIYEGAYHV LHKELPEVTN SVFHEINMWV SQRTATAGTA SPP.

Host

E Coli

Form/Format

Sterile filtered colorless solution.
The MGLL solution (0.5mg/ml) contains 20mM Tris-HCl Buffer (pH 8.0) and 10% Glycerol.

Purity/Purification

Greater than 85.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Molecular Weight

31,149 Da

OMIM

U67963 mRNA

3D Structure

ModBase 3D Structure for Q99685

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity is > 170 units/mg, and is defined as the amount of enzyme that hydrolyze 1.0 umole of p-nitrophenyl butyrate to pnitrophenol per minute at pH 7.5 at 25C.

Product Categories/Family for MGLL active protein

Enzymes

Other Notes

Small volumes of MGLL active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MGLL purchase

MBS146830 is an active protein targeting MGLL. Also known as Recombinant Human Monoglyceride Lipase, Active. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MGLL. It may not necessarily be applicable to this product.

NCBI GI #

51242953

NCBI GeneID

11343

NCBI Accession #

NP_001003794.1

UniProt Primary Accession #

Q99685

UniProt Secondary Accession #

Q6IBG9; Q96AA5; B3KRC2; B7Z9D1

UniProt Related Accession #

Q99685

GenBank Nucleotide #

NM_001003794.2

NCBI Official Full Name

monoglyceride lipase isoform 2

NCBI Official Synonym Full Names

monoglyceride lipase

NCBI Official Symbol

MGLL

NCBI Official Synonym Symbols

MGL; HUK5; MAGL; HU-K5

UniProt Protein Name

Monoglyceride lipase

UniProt Synonym Protein Names

HU-K5

Protein Family

Monoglyceride lipase

UniProt Gene Name

MGLL

UniProt Synonym Gene Names

MAGL

NCBI Protein Information

monoglyceride lipase

NCBI Summary for MGLL

This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

UniProt Comments for MGLL

MGLL: Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth. Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family.

Protein type: EC 3.1.1.23; Lipid Metabolism - glycerolipid; Phospholipase

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: cytosol; endoplasmic reticulum membrane; extrinsic to membrane; membrane; nucleoplasm; plasma membrane

Molecular Function: acylglycerol lipase activity; lysophospholipase activity; protein homodimerization activity

Biological Process: acylglycerol catabolic process; arachidonic acid metabolic process; inflammatory response; lipid metabolic process; regulation of inflammatory response; regulation of sensory perception of pain; regulation of signal transduction

Research Articles on MGLL

1. there was evidence that MGLL rs604300 genotype interacts with early life adversity to predict threat-related basolateral amygdala habituation, a neural phenotype linked to the endocannabinoid system and addiction

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MGLL active protein

Reference Product	PubMed Publications
PNPLA2 active protein	>3 publications with MGLL and PNPLA2
LIPE active protein	>3 publications with MGLL and LIPE
LPL active protein	>1 publications with MGLL and LPL

Pathways associated with MGLL active protein

Products by Pathway	Pathway Diagram
Acyl Chain Remodeling Of DAG And TAG Pathway antibodies	Acyl Chain Remodeling Of DAG And TAG Pathway Diagram
Acylglycerol Degradation Pathway antibodies	Acylglycerol Degradation Pathway Diagram
Acylglycerol Degradation Pathway antibodies	Acylglycerol Degradation Pathway Diagram
Arachidonate Production From DAG Pathway antibodies	Arachidonate Production From DAG Pathway Diagram
Effects Of PIP2 Hydrolysis Pathway antibodies	Effects Of PIP2 Hydrolysis Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Glycerolipid Metabolism Pathway antibodies	Glycerolipid Metabolism Pathway Diagram
Glycerolipid Metabolism Pathway antibodies	Glycerolipid Metabolism Pathway Diagram

Diseases associated with MGLL active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>4 publications with MGLL and Inflammation
Disease Models, Animal Antibodies	>3 publications with MGLL and Disease Models, Animal
Fatty Liver Antibodies	>3 publications with MGLL and Fatty Liver
Breast Neoplasms Antibodies	>2 publications with MGLL and Breast Neoplasms
Liver Diseases Antibodies	>2 publications with MGLL and Liver Diseases
Cardiovascular Diseases Antibodies	>1 publications with MGLL and Cardiovascular Diseases
Weight Gain Antibodies	>1 publications with MGLL and Weight Gain
Weight Loss Antibodies	>1 publications with MGLL and Weight Loss
Prenatal Exposure Delayed Effects Antibodies	>1 publications with MGLL and Prenatal Exposure Delayed Effects
Necrosis Antibodies	>1 publications with MGLL and Necrosis

Organs/Tissues associated with MGLL active protein

Organ/Tissue Name	Pubmed Publications
Adipose Tissue Antibodies	>5 publications with MGLL and Adipose Tissue
Blood Antibodies	>5 publications with MGLL and Blood
Liver Antibodies	>4 publications with MGLL and Liver
Muscle Antibodies	>3 publications with MGLL and Muscle
Intestine Antibodies	>3 publications with MGLL and Intestine
Connective Tissue Antibodies	>2 publications with MGLL and Connective Tissue
Brain Antibodies	>2 publications with MGLL and Brain
Vascular Antibodies	>1 publications with MGLL and Vascular
Skin Antibodies	>1 publications with MGLL and Skin
Pancreas Antibodies	>1 publications with MGLL and Pancreas