Disulfide Isomerase A6 (PDIA6) Active Protein

Name: PDIA6 Active Protein; Disulfide Isomerase A6; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS146841
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146841

Description: PDIA6 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 442 amino acids (20-440 a.a.) and having a molecular mass of 48.5kDa. The PDIA6 is purified by… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Disulfide Isomerase A6 (PDIA6), Active Protein

Full Product Name

Recombinant Human Protein Disulfide Isomerase A6, Active

Product Gene Name

PDIA6 active protein

Product Synonym Names

PDIA6 Human, Active; Protein disulfide-isomerase A6; Endoplasmic reticulum protein 5; ER protein 5; ERp5; Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7; PDIA6; ERP5; P5; TXNDC7; Protein Disulfide Isomerase A6 Human Recombinant, Active

Sequence

MGSSHHH HHH SSGLVPRGSH MLYSSS DDVI ELTPSNFNRE VIQSDSLWLV EFYAPWCGHC QRLTPEWKKA ATALKDVVKV GAVDADKHHS LGGQYGVQGF PTIKIFGSNK NRPEDYQGGR TGEAIVDAAL SALRQLVKDR LGGRSGGYSS GKQGRSDSSS KKDVIELTDD SFDKNVLDSE DVWMVEFYAP WCGHCKNLEP EWAAAASEVK EQTKGKVKLA AVDATVNQVL ASRYGIRGFP TIKIFQKGES PVDYDGGRTR SDIVSRALDL FSDNAPPPEL LEIINEDIAK RTCEEHQLCV VAVLPHILDT GAAGRNSYLE VLLKLADKYK KKMWGWLWTE AGAQSELETA LGIGGFGYPA MAAINARKMK FALLKGSFSE QGINEFLREL SFGRGSTAPV GGGAFPTIVE REPWDGRDGE LPVEDDIDLS DVELDDLGKD EL

Host

E Coli

Form/Format

Sterile filtered colorless solution.
The PDIA6 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 2mM DTT and 50mM NaCl.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Molecular Weight

53,261 Da

OMIM

D49489 mRNA

3D Structure

ModBase 3D Structure for Q15084

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity > 20_A650/cm/min/mg. Enzymatic activity was confirmed by measuring the aggregation of insulin in the presence of DTT.

Product Categories/Family for PDIA6 active protein

Enzymes

Other Notes

Small volumes of PDIA6 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDIA6 purchase

MBS146841 is an active protein targeting PDIA6. Also known as Recombinant Human Protein Disulfide Isomerase A6, Active. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PDIA6. It may not necessarily be applicable to this product.

NCBI GI #

544186032

NCBI GeneID

10130

NCBI Accession #

NP_001269633.1

UniProt Primary Accession #

Q15084

UniProt Secondary Accession #

Q53RC7; Q6ZSH5; Q99778; B3KY95; B5MCQ5; B7Z254; B7Z4M8; F8WA83

UniProt Related Accession #

Q15084

GenBank Nucleotide #

NM_001282704.1

NCBI Official Full Name

protein disulfide-isomerase A6 isoform a

NCBI Official Synonym Full Names

protein disulfide isomerase family A member 6

NCBI Official Symbol

PDIA6

NCBI Official Synonym Symbols

P5; ERP5; TXNDC7

UniProt Protein Name

Protein disulfide-isomerase A6

UniProt Synonym Protein Names

Endoplasmic reticulum protein 5; ER protein 5; ERp5; Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7

Protein Family

Protein disulfide-isomerase

UniProt Gene Name

PDIA6

UniProt Synonym Gene Names

ERP5; P5; TXNDC7; ER protein 5; ERp5

NCBI Protein Information

protein disulfide-isomerase A6

NCBI Summary for PDIA6

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

UniProt Comments for PDIA6

May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.

Research Articles on PDIA6

1. ACE and PDIA6 were identified as potential HSPA2-interacting proteins; this assemblage resides in membrane raft microdomains located in the peri-acrosomal region of the sperm head.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PDIA6 active protein

Reference Product	PubMed Publications
PDIA4 active protein	>5 publications with PDIA6 and PDIA4
HSPA5 active protein	>4 publications with PDIA6 and HSPA5
HSP90B1 active protein	>2 publications with PDIA6 and HSP90B1

Pathways associated with PDIA6 active protein

Products by Pathway	Pathway Diagram
IRE1alpha Activates Chaperones Pathway antibodies	IRE1alpha Activates Chaperones Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram
Unfolded Protein Response (UPR) Pathway antibodies	Unfolded Protein Response (UPR) Pathway Diagram
XBP1(S) Activates Chaperone Genes Pathway antibodies	XBP1(S) Activates Chaperone Genes Pathway Diagram

Diseases associated with PDIA6 active protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>3 publications with PDIA6 and Nervous System Diseases
Liver Diseases Antibodies	>2 publications with PDIA6 and Liver Diseases
Kidney Diseases Antibodies	>2 publications with PDIA6 and Kidney Diseases
Inflammation Antibodies	>2 publications with PDIA6 and Inflammation
Brain Diseases Antibodies	>1 publications with PDIA6 and Brain Diseases
Cardiovascular Diseases Antibodies	>1 publications with PDIA6 and Cardiovascular Diseases
Carcinoma, Hepatocellular Antibodies	>1 publications with PDIA6 and Carcinoma, Hepatocellular
Disease Models, Animal Antibodies	>1 publications with PDIA6 and Disease Models, Animal

Organs/Tissues associated with PDIA6 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>6 publications with PDIA6 and Blood
Lung Antibodies	>4 publications with PDIA6 and Lung
Brain Antibodies	>4 publications with PDIA6 and Brain
Liver Antibodies	>3 publications with PDIA6 and Liver
Vascular Antibodies	>2 publications with PDIA6 and Vascular
Kidney Antibodies	>2 publications with PDIA6 and Kidney
Pancreas Antibodies	>2 publications with PDIA6 and Pancreas
Muscle Antibodies	>2 publications with PDIA6 and Muscle
Bone Marrow Antibodies	>2 publications with PDIA6 and Bone Marrow
Heart Antibodies	>2 publications with PDIA6 and Heart