Human DCTN2 Recombinant Protein – Cat# MBS146883

Dynactin 2 (DCTN2) Human Recombinant Protein

Name: DCTN2 Recombinant Protein; Dynactin 2; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146883
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146883

Description: Dynactin 2 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 426 amino acids (1-403 a.a) and having a molecular mass of 46.9kDa.DCTN2 is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Dynactin 2 (DCTN2), Recombinant Protein

Full Product Name

Recombinant Human Dynactin 2 (1-403 a.a.)

Product Gene Name

DCTN2 recombinant protein

Product Synonym Names

DCTN2 (1-403) Human; Dynactin 2 (P50); 50 KDa Dynein-Associated Polypeptide; Dynactin Complex 50 KDa Subunit; P50 Dynamitin; DCTN50; 50 KD Dynein-Associated Polypeptide; Epididymis Secretory Protein Li 77; Dynactin Complex 50 KD Subunit; DYNAMITIN; HEL-S-77; DCTN-50; RBP50; Dynactin 2 (1-403 a.a.) Human Recombinant

Sequence

MGSSHHH HHH SSGLVPRGSH MGSMAD PKYA DLPGIARNEP DVYETSDLPE DDQAEFDAEL EELTSTSVEH IIVNPNAAYD KFKDKRVGTK GLDFSDRIGK TKRTGYESGE YEMLGEGLGV KETPQQKYQR LLHEVQELTT EVEKIKTTVK ESATEEKLTP VLLAKQLAAL KQQLVASHLE KLLGPDAAIN LTDPDGALAK RLLLQLEATK NSKGGSGGKT TGTPPDSSLV TYELHSRPEQ DKFSQAAKVA ELEKRLTELE TAVRCDQDAQ NPLSAGLQGA CLMETVELLQ AKVSALDLAV LDQVEARLQS VLGKVNEIAK HKASVEDADT QSKVHQLYET IQRWSPIAST LPELVQRLVT IKQLHEQAMQ FGQLLTHLDT TQQMIANSLK DNTTLLTQVQ TTMRENLATV EGNFASIDER MKKLGK

Host

E Coli

Form/Format

Sterile filtered colorless solution.
DCTN2 protein solution (0.5mg/ml) containing 20mM Tris-HCl (pH8.0), 10% glycerol, 0.15M NaCl and 1mM DTT.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Molecular Weight

44,473 Da

OMIM

U50733 mRNA

3D Structure

ModBase 3D Structure for Q13561

Product Categories/Family for DCTN2 recombinant protein

Recombinant & Natural Proteins

Other Notes

Small volumes of DCTN2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DCTN2 purchase

MBS146883 is a recombinant protein targeting DCTN2. Also known as Recombinant Human Dynactin 2 (1-403 a.a.). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for DCTN2. It may not necessarily be applicable to this product.

NCBI GI #

387527972

NCBI GeneID

10540

NCBI Accession #

NP_001248341.1

UniProt Primary Accession #

Q13561

UniProt Secondary Accession #

Q86YN2; Q9BW17; B2RBK5

UniProt Related Accession #

Q13561

GenBank Nucleotide #

NM_001261412.1

NCBI Official Full Name

dynactin subunit 2 isoform 2

NCBI Official Synonym Full Names

dynactin subunit 2

NCBI Official Symbol

DCTN2

NCBI Official Synonym Symbols

RBP50; DCTN50; HEL-S-77; DYNAMITIN

UniProt Protein Name

Dynactin subunit 2

UniProt Synonym Protein Names

50 kDa dynein-associated polypeptide; Dynactin complex 50 kDa subunit; DCTN-50; p50 dynamitin

Protein Family

Dynactin

UniProt Gene Name

DCTN2

UniProt Synonym Gene Names

DCTN50; DCTN-50

NCBI Protein Information

dynactin subunit 2

NCBI Summary for DCTN2

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]

UniProt Comments for DCTN2

dynactin 2: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. Belongs to the dynactin subunit 2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: centrosome; cytoplasm; cytosol; dynactin complex; kinetochore; vesicle

Molecular Function: identical protein binding; protein binding; spectrin binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; cell proliferation; ER to Golgi vesicle-mediated transport; G2/M transition of mitotic cell cycle; mitosis; mitotic spindle organization and biogenesis

Research Articles on DCTN2

1. This is the first time a haplotype on chromosome 12 containing sequence variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A has been linked to an inherited neuropathy in humans.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DCTN2 recombinant protein

Reference Product	PubMed Publications
GNAO1 recombinant protein	>1 publications with DCTN2 and GNAO1

Pathways associated with DCTN2 recombinant protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
Centrosome Maturation Pathway antibodies	Centrosome Maturation Pathway Diagram
G2/M Transition Pathway antibodies	G2/M Transition Pathway Diagram
Huntington's Disease Pathway antibodies	Huntington's Disease Pathway Diagram
Huntington's Disease Pathway antibodies	Huntington's Disease Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Loss Of Nlp From Mitotic Centrosomes Pathway antibodies	Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
Loss Of Proteins Required For Interphase Microtubule OrganizationÃ‚Â From The Centrosome Pathway antibodies	Loss Of Proteins Required For Interphase Microtubule OrganizationÃ‚Â From The Centrosome Pathway Diagram

Diseases associated with DCTN2 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>2 publications with DCTN2 and Neoplasms
Adenocarcinoma Antibodies	>1 publications with DCTN2 and Adenocarcinoma
Breast Neoplasms Antibodies	>1 publications with DCTN2 and Breast Neoplasms

Organs/Tissues associated with DCTN2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with DCTN2 and Brain
Spinal Cord Antibodies	>1 publications with DCTN2 and Spinal Cord
Nerve Antibodies	>1 publications with DCTN2 and Nerve
Bone Antibodies	>1 publications with DCTN2 and Bone
Liver Antibodies	>1 publications with DCTN2 and Liver