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Meprin A Beta (MEP1B) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146892

Description: MEP1B produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 642 amino acids (21-654aa) and having a molecular mass of 72.6kDa. (Molecular size on SDS-PAGE will appear at approximately 70-100kDa). MEP1Bis expressed… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Meprin A Beta (MEP1B), Recombinant Protein
Full Product Name
Recombinant Mouse Meprin A Beta
Product Gene Name
MEP1B recombinant protein
Product Synonym Names
MEP1B Mouse; Meprin A subunit beta (EC: 3.4.24.63); Endopeptidase-2; Meprin B; Mep1b; Mep-1b; Meprin A Beta Mouse Recombinant
Sequence
LPAPEKFVKD IDGGIDQDIF DINQGLGLDL FEGDIKLEAN GKNSIIGDHK RWPHTIPYVL EDSLEMNAKG VILNAFERYR LKTCIDFKPW SGEANYISVF KGSGCWSSVG NIHAGKQELS IGTNCDRIAT VQHEFLHALG FWHEQSRADR DDYVIIVWDR IQPGKEHNFN IYNDSVSDSL NVPYDYTSVM HYSKTAFQNG TESTIVTRIS EFEDVIGQRM DFSDYDLLKL NQLYNCTSSL SFMDSCDFEL ENICGMIQSS GDSADWQRVS QVLSGPESDH SKMGQCKDSG FFMHFNTSIL NEGATAMLES RLLYPKRGFQ CLEFYLYNSG SGNDQLNIYT REYTTGQQGG VLTLQRQIKE VPIGSWQLHY VTLQVTKKFR VVFEGLRGPG TSSGGLSIDD INLSETRCPH HIWHIQNFTQ ILGGQDTSVY SPPFYSSKGY AFQIYMDLRS STNVGIYFHL ISGANDDQLQ WPCPWQQATM TLLDQNPDIR QRMFNQRSIT TDPTMTSDNG SYFWDRPSKV GVTDVFPNGT QFSRGIGYGT TVFITRERLK SREFIKGDDI YILLTVEDIS HLNSTSAVPD PVPTLAVHNA CSEVVCQNGG ICVVQDGRAE CKCPAGEDWW YMGKRCEKRG STRDVEH HHH HH.
Host
Sf9 Insect cells
Form/Format
Sterile filtered colorless solution.
MEP1B protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Molecular Weight
80,348 Da
3D Structure
ModBase 3D Structure for Q61847

Product Categories/Family for MEP1B recombinant protein

Recombinant & Natural Proteins

Other Notes

Small volumes of MEP1B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MEP1B purchase

MBS146892 is a recombinant protein targeting MEP1B. Also known as Recombinant Mouse Meprin A Beta. Host: Sf9 Insect cells.

Additional Details

NCBI/Uniprot data below describe general gene information for MEP1B. It may not necessarily be applicable to this product.

NCBI GI #
147901863
NCBI GeneID
17288
NCBI Accession #
NP_032612.2
UniProt Primary Accession #
Q61847
UniProt Secondary Accession #
Q059K0
UniProt Related Accession #
Q61847
GenBank Nucleotide #
NM_008586.2
NCBI Official Full Name
meprin A subunit beta
NCBI Official Synonym Full Names
meprin 1 beta
NCBI Official Symbol
Mep1b
NCBI Official Synonym Symbols
Mep-1b
UniProt Protein Name
Meprin A subunit beta
UniProt Synonym Protein Names
Endopeptidase-2; Meprin B
Protein Family
Meprin
UniProt Gene Name
Mep1b
UniProt Synonym Gene Names
Mep-1b
NCBI Protein Information
meprin A subunit beta

UniProt Comments for MEP1B

MEP1B: Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011]

Protein type: EC 3.4.24.63; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 18 A2|18 11.81 cM

Cellular Component: membrane

Molecular Function: metalloendopeptidase activity
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Research Articles on MEP1B

1. meprin alpha and meprin beta join the modulators of Reelin signalling as they cleave Reelin at a specific site and are upregulated under specific pathological conditions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with MEP1B recombinant protein

 Products by Pathway  Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram

Diseases associated with MEP1B recombinant protein

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >2 publications with MEP1B and Kidney Diseases
 Liver Neoplasms Antibodies  >1 publications with MEP1B and Liver Neoplasms
 Fibrosis Antibodies  >1 publications with MEP1B and Fibrosis
 Liver Diseases Antibodies  >1 publications with MEP1B and Liver Diseases
 Acute Kidney Injury Antibodies  >1 publications with MEP1B and Acute Kidney Injury

Organs/Tissues associated with MEP1B recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >4 publications with MEP1B and Kidney
 Embryonic Tissue Antibodies  >3 publications with MEP1B and Embryonic Tissue
 Intestine Antibodies  >3 publications with MEP1B and Intestine
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