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Serine/Threonine-Protein Kinase RIO1 (RIOK1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1468999

This gene includes two alternatively spliced transcript variants, which encode different isoforms. The function of this gene has not been determined. More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Serine/threonine-protein kinase RIO1 (RIOK1), Recombinant Protein
Full Product Name
Recombinant Human Serine/threonine-protein kinase RIO1 (RIOK1)
Product Gene Name
RIOK1 recombinant protein
Product Synonym Gene Name
RIOK1
Sequence
MDYRRLLMSR VVPGQFDDAD SSDSENRDLK TVKEKDDILF EDLQDNVNEN GEGEIEDEEE EGYDDDDDDW DWDEGVGKLA KGYVWNGGSN PQANRQTSDS SSAKMSTPAD KVLRKFENKI NLDKLNVTDS VINKVTEKSR QKEADMYRIK DKADRATVEQ VLDPRTRMIL FKMLTRGIIT EINGCISTGK EANVYHASTA NGESRAIKIY KTSILVFKDR DKYVSGEFRF RHGYCKGNPR KMVKTWAEKE MRNLIRLNTA EIPCPEPIML RSHVLVMSFI GKDDMPAPLL KNVQLSESKA RELYLQVIQY MRRMYQDARL VHADLSEFNM LYHGGGVYII DVSQSVEHDH PHALEFLRKD CANVNDFFMR HSVAVMTVRE LFEFVTDPSI THENMDAYLS KAMEIASQRT KEERSSQDHV DEEVFKRAYI PRTLNEVKNY ERDMDIIMKL KEEDMAMNAQ QDNILYQTVT GLKKDLSGVQ KVPALLENQV EERTCSDSED IGSSECSDTD SEEQGDHARP KKHTTDPDID KKERKKMVKE AQREKRKNKI PKHVKKRKEK TAKTKKGK
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
65,583 Da
Sequence Positions
1-568, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
617753
3D Structure
ModBase 3D Structure for Q9BRS2
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RIOK1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RIOK1 purchase

MBS1468999 is a recombinant protein targeting RIOK1. Also known as Recombinant Human Serine/threonine-protein kinase RIO1 (RIOK1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for RIOK1. It may not necessarily be applicable to this product.

NCBI GI #
23510356
NCBI GeneID
83732
NCBI Accession #
NP_113668.2
UniProt Primary Accession #
Q9BRS2
UniProt Secondary Accession #
Q8NDC8; Q96NV9; B2RB28
UniProt Related Accession #
Q9BRS2
GenBank Nucleotide #
NM_031480.2
NCBI Official Full Name
serine/threonine-protein kinase RIO1 isoform 1
NCBI Official Synonym Full Names
RIO kinase 1
NCBI Official Symbol
RIOK1
NCBI Official Synonym Symbols
RIO1; AD034; RRP10; bA288G3.1
UniProt Protein Name
Serine/threonine-protein kinase RIO1
UniProt Synonym Protein Names
RIO kinase 1
UniProt Gene Name
RIOK1
NCBI Protein Information
serine/threonine-protein kinase RIO1

NCBI Summary for RIOK1

The protein encoded by this gene competes with pICln for inclusion in the protein arginine methyltransferase 5 complex. This complex targets substrates for dimethylation. The encoded protein is essential for the last steps in the maturation of 40S subunits. [provided by RefSeq, Jan 2017]

UniProt Comments for RIOK1

Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (). Despite the protein kinase domain is proposed to act predominantly as an ATPase (). The catalytic activity regulates its dynamic association with the 40S subunit ().
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Research Articles on RIOK1

1. Docking studies revealed that TIBI can occupy the ATP-binding site of Rio1 in a manner similar to toyocamycin, and enhances the thermostability of the enzyme.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RIOK1 recombinant protein

 Reference Product  PubMed Publications
 PRMT5 recombinant protein  >3 publications with RIOK1 and PRMT5
 TGFBRAP1 recombinant protein  >1 publications with RIOK1 and TGFBRAP1
 RASGEF1A recombinant protein  >1 publications with RIOK1 and RASGEF1A
 SBNO1 recombinant protein  >1 publications with RIOK1 and SBNO1

Pathways associated with RIOK1 recombinant protein

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Major Pathway Of RRNA Processing In The Nucleolus And Cytosol antibodies  Major Pathway Of RRNA Processing In The Nucleolus And Cytosol Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram
 RRNA Processing Pathway antibodies  RRNA Processing Pathway Diagram
 RRNA Processing In The Nucleus And Cytosol Pathway antibodies  RRNA Processing In The Nucleus And Cytosol Pathway Diagram

Diseases associated with RIOK1 recombinant protein

 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >2 publications with RIOK1 and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >1 publications with RIOK1 and Lung Neoplasms

Organs/Tissues associated with RIOK1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Stomach Antibodies  >1 publications with RIOK1 and Stomach
 Uterus Antibodies  >1 publications with RIOK1 and Uterus
 Lung Antibodies  >1 publications with RIOK1 and Lung
 Brain Antibodies  >1 publications with RIOK1 and Brain
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