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C-Type Lectin Domain Family 1, Member B (CLEC1B) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146929

Description: CLEC1B Human Recombinant produced in Sf9 Baculovirus cells is a single, non-glycosylated polypeptide chain containing 184 amino acids (55-229a.a) and having a molecular mass of 21.8kD (Molecular size on SDS-PAGE will appear at approximately… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
C-type Lectin Domain Family 1, Member B (CLEC1B), Recombinant Protein
Full Product Name
Recombinant Human C-type Lectin Domain Family 1, Member B, Sf9
Product Gene Name
CLEC1B recombinant protein
Product Synonym Names
CLEC1B Human, Sf9; C-Type Lectin Domain Family 1 Member B; C-Type Lectin-Like Receptor 2; CLEC-2; CLEC2; C-Type Lectin Domain Family 1; Member B; 1810061I13Rik; PRO1384; QDED721; CLEC2B; C-type lectin domain family 1 member B; C-type lectin-like receptor 2; C-type Lectin Domain Family 1, Member B, Human Recombinant, Sf9
Sequence
ADP SVMQRNYLQG ENENRTG TLQQLAKRFC QYVVKQSELK GTFKGHKCSP CDTNWRYYGD SCYGFFRHNL TWEESKQYCT DMNATLLKID NRNIVEYIKA RTHLIRWVGL SRQKSNEVWK WEDGSVISEN MFEFLEDGKG NMNCAYFHNG KMHPTFCENK HYLMCERKAG MTKVDQLPHH HHHH.
Host
Sf9, Baculovirus cells
Form/Format
Sterile filtered colorless solution.
CLEC1B protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Molecular Weight
23,096 Da
OMIM
AF124841 mRNA
3D Structure
ModBase 3D Structure for Q9P126

Product Categories/Family for CLEC1B recombinant protein

Recombinant & Natural Proteins

Other Notes

Small volumes of CLEC1B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLEC1B purchase

MBS146929 is a recombinant protein targeting CLEC1B. Also known as Recombinant Human C-type Lectin Domain Family 1, Member B, Sf9. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CLEC1B. It may not necessarily be applicable to this product.

NCBI GI #
153252048
NCBI GeneID
51266
NCBI Accession #
NP_001092901.1
UniProt Primary Accession #
Q9P126
UniProt Secondary Accession #
Q6UWX7; Q8NHR6
UniProt Related Accession #
Q9P126
GenBank Nucleotide #
NM_001099431.1
NCBI Official Full Name
C-type lectin domain family 1 member B isoform b
NCBI Official Synonym Full Names
C-type lectin domain family 1 member B
NCBI Official Symbol
CLEC1B
NCBI Official Synonym Symbols
CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik
UniProt Protein Name
C-type lectin domain family 1 member B
UniProt Synonym Protein Names
C-type lectin-like receptor 2; CLEC-2
Protein Family
C-type lectin domain family
UniProt Gene Name
CLEC1B
UniProt Synonym Gene Names
CLEC2; CLEC-2
NCBI Protein Information
C-type lectin domain family 1 member B

NCBI Summary for CLEC1B

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]
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UniProt Comments for CLEC1B

CLEC1B: Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 12p13.31-p13.2

Cellular Component: plasma membrane

Molecular Function: protein binding; transmembrane receptor activity

Biological Process: cell surface receptor linked signal transduction; defense response; platelet activation
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Research Articles on CLEC1B

1. CLEC-2 regulates Akt and MAPK downstream of PI3K and PKC, leading to phosphorylation and inhibition of GSK3alpha/beta, and enhanced platelet aggregation and secretion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CLEC1B recombinant protein

 Products by Pathway  Pathway Diagram
 GPVI-mediated Activation Cascade Pathway antibodies  GPVI-mediated Activation Cascade Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram

Diseases associated with CLEC1B recombinant protein

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2 publications with CLEC1B and Carcinoma
 Carcinoma, Hepatocellular Antibodies  >2 publications with CLEC1B and Carcinoma, Hepatocellular
 Hypersensitivity Antibodies  >1 publications with CLEC1B and Hypersensitivity
 Neoplasm Metastasis Antibodies  >1 publications with CLEC1B and Neoplasm Metastasis
 Liver Diseases Antibodies  >1 publications with CLEC1B and Liver Diseases
 Lung Diseases Antibodies  >1 publications with CLEC1B and Lung Diseases
 Liver Neoplasms Antibodies  >1 publications with CLEC1B and Liver Neoplasms
 Fibrosis Antibodies  >1 publications with CLEC1B and Fibrosis
 Lung Neoplasms Antibodies  >1 publications with CLEC1B and Lung Neoplasms

Organs/Tissues associated with CLEC1B recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with CLEC1B and Liver
 Lung Antibodies  >1 publications with CLEC1B and Lung
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