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E3 Ubiquitin-Protein Ligase RNF14 (RNF14) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1470179

This protein contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant… More details

$1255 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
E3 ubiquitin-protein ligase RNF14 (RNF14), Recombinant Protein
Full Product Name
Recombinant Human E3 ubiquitin-protein ligase RNF14 (RNF14)
Product Gene Name
RNF14 recombinant protein
Product Synonym Gene Name
RNF14
Sequence
MSSEDREAQE DELLALASIY DGDEFRKAES VQGGETRIYL DLPQNFKIFV SGNSNECLQN SGFEYTICFL PPLVLNFELP PDYPSSSPPS FTLSGKWLSP TQLSALCKHL DNLWEEHRGS VVLFAWMQFL KEETLAYLNI VSPFELKIGS QKKVQRRTAQ ASPNTELDFG GAAGSDVDQE EIVDERAVQD VESLSNLIQE ILDFDQAQQI KCFNSKLFLC SICFCEKLGS ECMYFLECRH VYCKACLKDY FEIQIRDGQV QCLNCPEPKC PSVATPGQVK ELVEAELFAR YDRLLLQSSL DLMADVVYCP RPCCQLPVMQ EPGCTMGICS SCNFAFCTLC RLTYHGVSPC KVTAEKLMDL RNEYLQADEA NKRLLDQRYG KRVIQKALEE MESKEWLEKN SKSCPCCGTP IEKLDGCNKM TCTGCMQYFC WICMGSLSRA NPYKHFNDPG SPCFNRLFYA VDVDDDIWED EVED
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
39,634 Da
Sequence Positions
1-474, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
605675
3D Structure
ModBase 3D Structure for Q9UBS8
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RNF14 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RNF14 purchase

MBS1470179 is a recombinant protein targeting RNF14. Also known as Recombinant Human E3 ubiquitin-protein ligase RNF14 (RNF14). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for RNF14. It may not necessarily be applicable to this product.

NCBI GI #
318067966
NCBI GeneID
9604
NCBI Accession #
NP_001188294.1
UniProt Primary Accession #
Q9UBS8
UniProt Secondary Accession #
O94793; Q6IBV0; A0AV26; A6NMR2; A8MTW5; B3KN72; B7ZLV2; D3DQE4
UniProt Related Accession #
Q9UBS8
GenBank Nucleotide #
NM_001201365.1
NCBI Official Full Name
E3 ubiquitin-protein ligase RNF14 isoform 1
NCBI Official Synonym Full Names
ring finger protein 14
NCBI Official Symbol
RNF14
NCBI Official Synonym Symbols
ARA54; HFB30; TRIAD2; HRIHFB2038
UniProt Protein Name
E3 ubiquitin-protein ligase RNF14
UniProt Synonym Protein Names
Androgen receptor-associated protein 54; HFB30; RING finger protein 14; Triad2 protein
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
RNF14
UniProt Synonym Gene Names
ARA54
NCBI Protein Information
E3 ubiquitin-protein ligase RNF14

NCBI Summary for RNF14

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]
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UniProt Comments for RNF14

Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.

Research Articles on RNF14

1. Ring Finger Protein 14 (RNF14) is a binding partner for all TCF/LEF transcription factors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RNF14 recombinant protein

 Reference Product  PubMed Publications
 NCOA4 recombinant protein  >11 publications with RNF14 and NCOA4

Pathways associated with RNF14 recombinant protein

 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram

Diseases associated with RNF14 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >13 publications with RNF14 and Neoplasms
 Genital Diseases, Male Antibodies  >12 publications with RNF14 and Genital Diseases, Male
 Prostatic Diseases Antibodies  >11 publications with RNF14 and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >11 publications with RNF14 and Prostatic Neoplasms
 Carcinoma Antibodies  >2 publications with RNF14 and Carcinoma
 Breast Neoplasms Antibodies  >1 publications with RNF14 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with RNF14 and Cell Transformation, Neoplastic
 Necrosis Antibodies  >1 publications with RNF14 and Necrosis

Organs/Tissues associated with RNF14 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >11 publications with RNF14 and Prostate
 Muscle Antibodies  >2 publications with RNF14 and Muscle
 Ovary Antibodies  >1 publications with RNF14 and Ovary
 Thyroid Antibodies  >1 publications with RNF14 and Thyroid
 Nerve Antibodies  >1 publications with RNF14 and Nerve
 Vascular Antibodies  >1 publications with RNF14 and Vascular
 Lymph Node Antibodies  >1 publications with RNF14 and Lymph Node
 Blood Antibodies  >1 publications with RNF14 and Blood
 Testis Antibodies  >1 publications with RNF14 and Testis
 Brain Antibodies  >1 publications with RNF14 and Brain
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