Human IL17RA Recombinant Protein – Cat# MBS147050

Interleukin-17 Receptor Alpha (IL17RA) Human Recombinant Protein

Name: IL17RA Recombinant Protein; Interleukin-17 Receptor Alpha; Human; MyBioSource
Brand: MyBioSource
SKU: MBS147050
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS147050

Description: IL17RA Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 527 amino acids (33-320) and having a molecular mass of 60.4kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa).… More details

$250 / 0.001 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin-17 Receptor Alpha (IL17RA), Recombinant Protein

Full Product Name

Recombinant Human Interleukin-17 Receptor Alpha

Product Gene Name

IL17RA recombinant protein

Product Synonym Names

Interleukin 17 Receptor A; IL-17 Receptor A; IL-17RA; CDw217; IL17R; Interleukin-17 Receptor A; Interleukin 17 Receptor; CD217 Antigen; HIL-17R; CANDF5; CD217; IMD51; IL17RA Human; Interleukin-17 Receptor Alpha Human Recombinant

Sequence

LRLLDHRALV CSQPGLNCTV KNSTCLDDSW IHPRNLTPSS PKDLQIQLHF AHTQQGDLFP VAHIEWTLQT DASILYLEGA ELSVLQLNTN ERLCVRFEFL SKLRHHHRRW RFTFSHFVVD PDQEYEVTVH HLPKPIPDGD PNHQSKNFLV PDCEHARMKV TTPCMSSGSL WDPNITVETL EAHQLRVSFT LWNESTHYQI LLTSFPHMEN HSCFEHMHHI PAPRPEEFHQ RSNVTLTLRN LKGCCRHQVQ IQPFFSSCLN DCLRHSATVS CPEMPDTPEP IPDYMPLWVE PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG KHHHHHH

Host

Sf9, Baculovirus cells

Form/Format

Sterile filtered colorless solution
Protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol

Purity/Purification

Greater than 90% as determined by SDS-PAGE

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at-20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles

Molecular Weight

92,153 Da

OMIM

U58917 mRNA

3D Structure

ModBase 3D Structure for Q96F46

Product Categories/Family for IL17RA recombinant protein

Cytokines and Growth Factors; Cytokines; Interleukin; IL17RA Human

Other Notes

Small volumes of IL17RA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL17RA purchase

MBS147050 is a recombinant protein targeting IL17RA. Also known as Recombinant Human Interleukin-17 Receptor Alpha. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for IL17RA. It may not necessarily be applicable to this product.

NCBI GI #

116242517

NCBI GeneID

23765

NCBI Accession #

Q96F46.2

UniProt Primary Accession #

Q96F46

UniProt Secondary Accession #

O43844; Q20WK1

UniProt Related Accession #

Q96F46

NCBI Official Full Name

Interleukin-17 receptor A

NCBI Official Synonym Full Names

interleukin 17 receptor A

NCBI Official Symbol

IL17RA

NCBI Official Synonym Symbols

CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R

UniProt Protein Name

Interleukin-17 receptor A

UniProt Synonym Protein Names

CDw217; CD_antigen: CD217

Protein Family

Interleukin-17 receptor

UniProt Gene Name

IL17RA

UniProt Synonym Gene Names

IL17R; IL-17 receptor A; IL-17RA

NCBI Protein Information

interleukin-17 receptor A

NCBI Summary for IL17RA

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

UniProt Comments for IL17RA

Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).

Research Articles on IL17RA

1. Here, we discuss the latest discoveries on the role of the IL-17A/IL-17RA axis in driving host pulmonary defence and immunopathology.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL17RA recombinant protein

Reference Product	PubMed Publications
IL17A recombinant protein	>117 publications with IL17RA and IL17A
IL17C recombinant protein	>116 publications with IL17RA and IL17C
IL17RC recombinant protein	>11 publications with IL17RA and IL17RC
IL17F recombinant protein	>10 publications with IL17RA and IL17F
TRAF6 recombinant protein	>6 publications with IL17RA and TRAF6
IL23A recombinant protein	>4 publications with IL17RA and IL23A
IL17RE recombinant protein	>2 publications with IL17RA and IL17RE

Pathways associated with IL17RA recombinant protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
IL17 Signaling Pathway antibodies	IL17 Signaling Pathway Diagram

Diseases associated with IL17RA recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>45 publications with IL17RA and Inflammation
Necrosis Antibodies	>23 publications with IL17RA and Necrosis
Disease Models, Animal Antibodies	>12 publications with IL17RA and Disease Models, Animal
Fibrosis Antibodies	>7 publications with IL17RA and Fibrosis
Carcinoma Antibodies	>6 publications with IL17RA and Carcinoma
Liver Diseases Antibodies	>4 publications with IL17RA and Liver Diseases
Hyperplasia Antibodies	>3 publications with IL17RA and Hyperplasia
Liver Neoplasms Antibodies	>2 publications with IL17RA and Liver Neoplasms
Kidney Diseases Antibodies	>2 publications with IL17RA and Kidney Diseases
Neoplasms, Experimental Antibodies	>2 publications with IL17RA and Neoplasms, Experimental

Organs/Tissues associated with IL17RA recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>62 publications with IL17RA and Blood
Lung Antibodies	>14 publications with IL17RA and Lung
Kidney Antibodies	>12 publications with IL17RA and Kidney
Bone Antibodies	>9 publications with IL17RA and Bone
Muscle Antibodies	>8 publications with IL17RA and Muscle
Heart Antibodies	>7 publications with IL17RA and Heart
Skin Antibodies	>7 publications with IL17RA and Skin
Intestine Antibodies	>7 publications with IL17RA and Intestine
Vascular Antibodies	>6 publications with IL17RA and Vascular
Bone Marrow Antibodies	>5 publications with IL17RA and Bone Marrow