Human IL10RB Recombinant Protein – Cat# MBS147052

Interleukin 10 Receptor Beta (IL10RB) Human Recombinant Protein

Name: IL10RB Recombinant Protein; Interleukin 10 Receptor Beta; Human; MyBioSource
Brand: MyBioSource
SKU: MBS147052
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS147052

Description: IL10RB Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 440 amino acids (20-220 a.a.) and having a molecular mass of 50.5kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa).… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin 10 Receptor Beta (IL10RB), Recombinant Protein

Full Product Name

Recombinant Human Interleukin 10 Receptor Beta

Product Gene Name

IL10RB recombinant protein

Product Synonym Names

Interleukin-10 receptor subunit beta; IL-10 receptor subunit beta; IL-10R subunit beta; IL-10RB; Cytokine receptor class-II member 4; Cytokine receptor family 2 member 4; CRF2-4; Interleukin-10 receptor subunit 2; IL-10R subunit 2; IL-10R2; CDw210b; IL10RB. ; IL10RB Human; Recombinant Human Interleukin 10 Receptor Beta

Sequence

MVPPPENVRM NSVNFKNILQ WESPAFAKGN LTFTAQYLSY RIFQDKCMNT TLTECDFSSL SKYGDHTLRV RAEFADEHSD WVNITFCPVD DTIIGPPGMQ VEVLADSLHM RFLAPKIENE YETWTMKNVY NSWTYNVQYW KNGTDEKFQI TPQYDFEVLR NLEPWTTYCV QVRGFLPDRN KAGEWSEPVC EQTTHDETVP SLEPKSCDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGKHHHHHH

Host

Sf9, Insect cells

Form/Format

Sterile filtered colorless solution
Protein solution (1.0mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at-20 degree C for longer periods of time.
For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles

Molecular Weight

36,995 Da

OMIM

Z17227 mRNA

3D Structure

ModBase 3D Structure for Q08334

Product Categories/Family for IL10RB recombinant protein

Cytokines and Growth Factors; Cytokines; Interleukin; IL10RB Human

Other Notes

Small volumes of IL10RB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL10RB purchase

MBS147052 is a recombinant protein targeting IL10RB. Also known as Recombinant Human Interleukin 10 Receptor Beta. Host: Sf9, Insect cells.

Additional Details

NCBI/Uniprot data below describe general gene information for IL10RB. It may not necessarily be applicable to this product.

NCBI GI #

56757647

NCBI GeneID

3588

NCBI Accession #

Q08334.2

UniProt Primary Accession #

Q08334

UniProt Secondary Accession #

Q9BUU4

UniProt Related Accession #

Q08334

NCBI Official Full Name

Interleukin-10 receptor subunit beta

NCBI Official Synonym Full Names

interleukin 10 receptor subunit beta

NCBI Official Symbol

IL10RB

NCBI Official Synonym Symbols

CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2

UniProt Protein Name

Interleukin-10 receptor subunit beta

UniProt Synonym Protein Names

Cytokine receptor class-II member 4; Cytokine receptor family 2 member 4; CRF2-4; Interleukin-10 receptor subunit 2; IL-10R subunit 2; IL-10R2; CD_antigen: CDw210b

Protein Family

Interleukin-10 receptor

UniProt Gene Name

IL10RB

UniProt Synonym Gene Names

CRFB4; D21S58; D21S66; IL-10 receptor subunit beta; IL-10R subunit beta; IL-10RB; CRF2-4; IL-10R subunit 2; IL-10R2

NCBI Protein Information

interleukin-10 receptor subunit beta

NCBI Summary for IL10RB

The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]

UniProt Comments for IL10RB

Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.

Research Articles on IL10RB

1. IL-10 and IL-10R gene polymorphisms may not contribute to the susceptibility to MM but may be associated with the severity and prognosis of MM. In particular, IL-10RB K47E polymorphism may contribute to the poor prognosis of MM patients treated with thalidomide and/or bortezomib.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL10RB recombinant protein

Reference Product	PubMed Publications
IL10RA recombinant protein	>22 publications with IL10RB and IL10RA
IL28B recombinant protein	>8 publications with IL10RB and IL28B
IL29 recombinant protein	>7 publications with IL10RB and IL29
IL28RA recombinant protein	>6 publications with IL10RB and IL28RA
IL22RA2 recombinant protein	>3 publications with IL10RB and IL22RA2
IL22RA1 recombinant protein	>3 publications with IL10RB and IL22RA1
IL28A recombinant protein	>2 publications with IL10RB and IL28A
JAK1 recombinant protein	>1 publications with IL10RB and JAK1

Pathways associated with IL10RB recombinant protein

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Interleukin-10 Signaling Pathway antibodies	Interleukin-10 Signaling Pathway Diagram
Interleukin-19, 20, 22, 24 Pathway antibodies	Interleukin-19, 20, 22, 24 Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram

Diseases associated with IL10RB recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>27 publications with IL10RB and Inflammation
Liver Diseases Antibodies	>11 publications with IL10RB and Liver Diseases
Necrosis Antibodies	>9 publications with IL10RB and Necrosis
Disease Models, Animal Antibodies	>5 publications with IL10RB and Disease Models, Animal
Fibrosis Antibodies	>4 publications with IL10RB and Fibrosis
Hepatitis B Antibodies	>4 publications with IL10RB and Hepatitis B
Carcinoma, Hepatocellular Antibodies	>3 publications with IL10RB and Carcinoma, Hepatocellular
Lung Neoplasms Antibodies	>3 publications with IL10RB and Lung Neoplasms
Cardiovascular Diseases Antibodies	>3 publications with IL10RB and Cardiovascular Diseases
Non-alcoholic Fatty Liver Disease Antibodies	>2 publications with IL10RB and Non-alcoholic Fatty Liver Disease

Organs/Tissues associated with IL10RB recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>34 publications with IL10RB and Blood
Liver Antibodies	>11 publications with IL10RB and Liver
Intestine Antibodies	>9 publications with IL10RB and Intestine
Lung Antibodies	>6 publications with IL10RB and Lung
Skin Antibodies	>6 publications with IL10RB and Skin
Brain Antibodies	>6 publications with IL10RB and Brain
Kidney Antibodies	>4 publications with IL10RB and Kidney
Heart Antibodies	>2 publications with IL10RB and Heart
Prostate Antibodies	>2 publications with IL10RB and Prostate
Lymph Antibodies	>2 publications with IL10RB and Lymph