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TERF1-Interacting Nuclear Factor 2 (TINF2) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1470669

MBS1470669 is a recombinant protein targeting TINF2. Also known as Recombinant Human TERF1-interacting nuclear factor 2 (TINF2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1225 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TERF1-interacting nuclear factor 2 (TINF2), Recombinant Protein
Full Product Name
Recombinant Human TERF1-interacting nuclear factor 2 (TINF2)
Product Gene Name
TINF2 recombinant protein
Product Synonym Gene Name
TINF2
Sequence
ATPLVAGPAA LRFAAAASWQ VVRGRCVEHF PRVLEFLRSL RAVAPGLVRY RHHERLCMGL KAKVVVELIL QGRPWAQVLK ALNHHFPESG PIVRDPKATK QDLRKILEAQ ETFYQQVKQL SEAPVDLASK LQELEQEYGE PFLAAMEKLL FEYLCQLEKA LPTPQAQQLQ DVLSWMQPGV SITSSLAWRQ YGVDMGWLLP ECSVTDSVNL AEPMEQNPPQ QQRLALHNPL PKAKPGTHLP QGPSSRTHPE PLAGRHFNLA PLGRRRVQSQ WASTRGGHKE RPTVMLFPFR NLGSPTQVIS KPESKEEHAI YTADLAMGTR AASTGKSKSP CQTLGGRALK ENPVDLPATE QKENCLDCYM DPLRLSLLPP RARKPVCPPS LCSSVITIGD LVLDSDEEEN GQGEGKESLE NYQKTKFDTL IPTLCEYLPP SGHGAIPVSS CDCRDSSRPL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
15,434 Da
Sequence Positions
2-451, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
268130
3D Structure
ModBase 3D Structure for Q9BSI4
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TINF2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TINF2. It may not necessarily be applicable to this product.

NCBI GI #
151101266
NCBI GeneID
26277
NCBI Accession #
NP_001092744.1
UniProt Primary Accession #
Q9BSI4
UniProt Secondary Accession #
Q9H904; Q9UHC2; B3W5Q7
UniProt Related Accession #
Q9BSI4
GenBank Nucleotide #
NM_001099274.1
NCBI Official Full Name
TERF1-interacting nuclear factor 2 isoform 1
NCBI Official Synonym Full Names
TERF1 interacting nuclear factor 2
NCBI Official Symbol
TINF2
NCBI Official Synonym Symbols
TIN2; DKCA3
UniProt Protein Name
TERF1-interacting nuclear factor 2
UniProt Synonym Protein Names
TRF1-interacting nuclear protein 2
Protein Family
TERF1-interacting nuclear factor
UniProt Gene Name
TINF2
UniProt Synonym Gene Names
TIN2
NCBI Protein Information
TERF1-interacting nuclear factor 2

NCBI Summary for TINF2

This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq, Mar 2010]
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UniProt Comments for TINF2

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
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Research Articles on TINF2

1. We report ophthalmic findings in twins with Revesz syndrome due to a previously unreported mutation in TINF2 and propose that phenotypic and molecular overlaps between DKC spectrum disorders and pediatric retinal vasculopathies may reflect a shared pathophysiologic basis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TINF2 recombinant protein

 Reference Product  PubMed Publications
 TERF2 recombinant protein  >9 publications with TINF2 and TERF2
 TERF1 recombinant protein  >4 publications with TINF2 and TERF1
 ACD recombinant protein  >3 publications with TINF2 and ACD

Pathways associated with TINF2 recombinant protein

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 Meiosis Pathway antibodies  Meiosis Pathway Diagram
 Meiotic Synapsis Pathway antibodies  Meiotic Synapsis Pathway Diagram
 Packaging Of Telomere Ends Pathway antibodies  Packaging Of Telomere Ends Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram
 Shelterin Complex Pathway antibodies  Shelterin Complex Pathway Diagram
 Telomere Maintenance Pathway antibodies  Telomere Maintenance Pathway Diagram

Diseases associated with TINF2 recombinant protein

 Disease Name  Pubmed Publications
 Dyskeratosis Congenita Antibodies  >33 publications with TINF2 and Dyskeratosis Congenita
 Neoplasms Antibodies  >13 publications with TINF2 and Neoplasms
 Dyskeratosis Congenita, Autosomal Dominant Antibodies  >9 publications with TINF2 and Dyskeratosis Congenita, Autosomal Dominant
 Kidney Diseases Antibodies  >8 publications with TINF2 and Kidney Diseases
 Bone Marrow Diseases Antibodies  >8 publications with TINF2 and Bone Marrow Diseases
 Fibrosis Antibodies  >7 publications with TINF2 and Fibrosis
 Death Antibodies  >4 publications with TINF2 and Death
 Nervous System Malformations Antibodies  >3 publications with TINF2 and Nervous System Malformations
 Growth Disorders Antibodies  >3 publications with TINF2 and Growth Disorders
 Hypertension Antibodies  >2 publications with TINF2 and Hypertension

Organs/Tissues associated with TINF2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >28 publications with TINF2 and Bone Marrow
 Bone Antibodies  >28 publications with TINF2 and Bone
 Blood Antibodies  >18 publications with TINF2 and Blood
 Kidney Antibodies  >11 publications with TINF2 and Kidney
 Skin Antibodies  >8 publications with TINF2 and Skin
 Liver Antibodies  >4 publications with TINF2 and Liver
 Vascular Antibodies  >4 publications with TINF2 and Vascular
 Stomach Antibodies  >4 publications with TINF2 and Stomach
 Eye Antibodies  >3 publications with TINF2 and Eye
 Lung Antibodies  >3 publications with TINF2 and Lung
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