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Erythropoietin Receptor (EPOR) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS147080

Description: EPOR produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 232 amino acids (25-250a.a.) and having a molecular mass of 25.6kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). EPOR is… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Erythropoietin Receptor (EPOR), Active Protein
Full Product Name
Recombinant Human Erythropoietin Receptor, Sf9
Product Gene Name
EPOR active protein
Product Synonym Names
EPO-R; EPOR; Erythropoietin Receptor; EPOR Human, Sf9; Erythropoietin Receptor Human Recombinant, Sf9
Sequence
APPPNLPDPK FESKAALLAA RGPEELLCFT ERLEDLVCFW EEAASAGVGP GNYSFSYQLE DEPWKLCRLH QAPTARGAVR FWCSLPTADT SSFVPLELRV TAASGAPRYH RVIHINEVVL LDAPVGLVAR LADESGHVVL RWLPPPETPM TSHIRYEVDV SAGNGAGSVQ RVEILEGRTE CVLSNLRGRT RYTFAVRARM AEPSFGGFWS AWSEPVSLLT PSDLDPHHHH HH.
Host
Sf9, Baculovirus cells
Form/Format
Sterile filtered clear solution
Protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol
Purity/Purification
Greater than 95.0% as determined by analysis by SDS-PAGE
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at-20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles
Molecular Weight
35,809 Da
OMIM
M60459 mRNA
3D Structure
ModBase 3D Structure for P19235
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Measured by its ability to inhibit EPO dependentproliferation assay using TF-1 human erythroleukemic cells. The ED50 for thiseffect less or equal to 70ng/ml

Product Categories/Family for EPOR active protein

Cytokines and Growth Factors; Growth Factors; Erythropoietin; EPOR Human; Sf9

Other Notes

Small volumes of EPOR active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EPOR purchase

MBS147080 is an active protein targeting EPOR. Also known as Recombinant Human Erythropoietin Receptor, Sf9. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for EPOR. It may not necessarily be applicable to this product.

NCBI GI #
119524
NCBI GeneID
2057
NCBI Accession #
P19235.1
UniProt Primary Accession #
P19235
UniProt Secondary Accession #
Q15443; Q2M205; B2RCG4
UniProt Related Accession #
P19235
NCBI Official Full Name
Erythropoietin receptor
NCBI Official Synonym Full Names
erythropoietin receptor
NCBI Official Symbol
EPOR
NCBI Official Synonym Symbols
EPO-R
UniProt Protein Name
Erythropoietin receptor
Protein Family
Erythropoietin receptor
UniProt Gene Name
EPOR
UniProt Synonym Gene Names
EPO-R
NCBI Protein Information
erythropoietin receptor

NCBI Summary for EPOR

This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
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UniProt Comments for EPOR

Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.

Research Articles on EPOR

1. High EPOR expression is associated with monoclonal gammopathy of undetermined significance and multiple myeloma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with EPOR active protein

 Reference Product  PubMed Publications
 EPO active protein  >722 publications with EPOR and EPO
 JAK2 active protein  >194 publications with EPOR and JAK2
 PTPN6 active protein  >14 publications with EPOR and PTPN6
 GRB2 active protein  >10 publications with EPOR and GRB2
 SOCS3 active protein  >8 publications with EPOR and SOCS3
 SOCS2 active protein  >6 publications with EPOR and SOCS2
 LYN active protein  >6 publications with EPOR and LYN
 CRKL active protein  >6 publications with EPOR and CRKL

Pathways associated with EPOR active protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 EPO Receptor Signaling Pathway antibodies  EPO Receptor Signaling Pathway Diagram
 EPO Signaling Pathway antibodies  EPO Signaling Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Kit Receptor Signaling Pathway antibodies  Kit Receptor Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram

Diseases associated with EPOR active protein

 Disease Name  Pubmed Publications
 Anemia Antibodies  >168 publications with EPOR and Anemia
 Polycythemia Antibodies  >79 publications with EPOR and Polycythemia
 Cardiovascular Diseases Antibodies  >73 publications with EPOR and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >63 publications with EPOR and Disease Models, Animal
 Kidney Diseases Antibodies  >40 publications with EPOR and Kidney Diseases
 Breast Neoplasms Antibodies  >32 publications with EPOR and Breast Neoplasms
 Inflammation Antibodies  >31 publications with EPOR and Inflammation
 Necrosis Antibodies  >29 publications with EPOR and Necrosis
 Adenocarcinoma Antibodies  >29 publications with EPOR and Adenocarcinoma
 Heart Diseases Antibodies  >19 publications with EPOR and Heart Diseases

Organs/Tissues associated with EPOR active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >357 publications with EPOR and Blood
 Bone Antibodies  >139 publications with EPOR and Bone
 Brain Antibodies  >111 publications with EPOR and Brain
 Kidney Antibodies  >89 publications with EPOR and Kidney
 Liver Antibodies  >76 publications with EPOR and Liver
 Heart Antibodies  >48 publications with EPOR and Heart
 Embryonic Tissue Antibodies  >33 publications with EPOR and Embryonic Tissue
 Lung Antibodies  >27 publications with EPOR and Lung
 Eye Antibodies  >25 publications with EPOR and Eye
 Skin Antibodies  >12 publications with EPOR and Skin
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