Human DUSP18 Active Protein – Cat# MBS147107

Dual Specificity Phosphatase 18 (DUSP18) Human Active Protein

Name: DUSP18 Active Protein; Dual Specificity Phosphatase 18; Human; MyBioSource
Brand: MyBioSource
SKU: MBS147107
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS147107

Description: DUSP18 produced in E Coli is a single, non-glycosylated polypeptide chain containing 212 amino acids (1-188a.a.) and having a molecular mass of 23.6kDa. DUSP18 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Dual Specificity Phosphatase 18 (DUSP18), Active Protein

Full Product Name

Recombinant Human Dual Specificity Phosphatase 18, Active

Product Gene Name

DUSP18 active protein

Product Synonym Names

Dual specificity protein phosphatase 18; Low molecular weight dual specificity phosphatase 20; LMW-DSP20; DUSP18; LMWDSP20; VHP; DUSP26; DUSP18 Human, Active; Dual Specificity Phosphatase 18 Human Recombinant, Active

Sequence

MGSSHHHHHH SSGLVPRGSH MGSH MTAPSC AFPVQFRQPS VSGLSQITKS LYISNGVAAN NKLMLSSNQI TMVINVSVEV VNTLYEDIQY MQVPVADSPN SRLCDFFDPI ADHIHSVEMK QGRTLLHCAA GVSRSAALCL AYLMKYHAMS LLDAHTWTKS CRPIIRPNSG FWEQLIHYEF QLFGKNTVHM VSSPVGMIPD IYEKEVRLMI PL

Host

Escherichia Coli

Form/Format

Sterile filtered clear solution
Protein solution (0.5mg/ml) is formulated in 20mM Tris-HCl buffer (pH8.0), 0.1mM PMSF, 1mM DTT, 40% glycerol and 1mM EDTA

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at-20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles

Molecular Weight

21,066 Da

OMIM

AF533017 mRNA

3D Structure

ModBase 3D Structure for Q8NEJ0

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity is > 300 units/mg, and is defined as the amount of enzyme that hydrolyze 1.0 nmole of p-nitrophenyl phosphate (pNPP) per minute at pH 7.5 at 37 degree C

Product Categories/Family for DUSP18 active protein

Enzymes; Phosphatase; DUSP18 Human; Active

Other Notes

Small volumes of DUSP18 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DUSP18 purchase

MBS147107 is an active protein targeting DUSP18. Also known as Recombinant Human Dual Specificity Phosphatase 18, Active. Host: Escherichia Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for DUSP18. It may not necessarily be applicable to this product.

NCBI GI #

29840768

NCBI GeneID

150290

NCBI Accession #

Q8NEJ0.1

UniProt Primary Accession #

Q8NEJ0

UniProt Secondary Accession #

B3KPA4

UniProt Related Accession #

Q8NEJ0

NCBI Official Full Name

Dual specificity protein phosphatase 18

NCBI Official Synonym Full Names

dual specificity phosphatase 18

NCBI Official Symbol

DUSP18

NCBI Official Synonym Symbols

DSP18; DUSP20; LMWDSP20

UniProt Protein Name

Dual specificity protein phosphatase 18

UniProt Synonym Protein Names

Low molecular weight dual specificity phosphatase 20

Protein Family

Dual specificity protein phosphatase

UniProt Gene Name

DUSP18

UniProt Synonym Gene Names

LMWDSP20; LMW-DSP20

NCBI Protein Information

dual specificity protein phosphatase 18

NCBI Summary for DUSP18

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

UniProt Comments for DUSP18

Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).

Research Articles on DUSP18

1. The crystal structure of human DSP18 (official symbol DUSP18) has been determined at 2.0 A resolution.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with DUSP18 active protein

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>3 publications with DUSP18 and Testis
Liver Antibodies	>2 publications with DUSP18 and Liver
Brain Antibodies	>2 publications with DUSP18 and Brain
Ovary Antibodies	>1 publications with DUSP18 and Ovary