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Neuroligin-1 (NLGN1) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1471251

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. More details

$1970 / 0.5 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Neuroligin-1 (Nlgn1), Recombinant Protein
Full Product Name
Recombinant Rat Neuroligin-1 (Nlgn1), partial
Product Gene Name
Nlgn1 recombinant protein
Product Synonym Gene Name
Nlgn1
Sequence
QKLDD VDPLVTTNFG KIRGIKKELN NEILGPVIQF LGVPYAAPPT GEHRFQPPEP PSPWSDIRNA TQFAPVCPQN IIDGRLPEVM LPVWFTNNLD VVSSYVQDQS EDCLYLNIYV PTEDVKRISK ECARKPGKKI CRKGDIRDSG GPKPVMVYIH GGSYMEGTGN LYDGSVLASY GNVIVITVNY RLGVLGFLST GDQAAKGNYG LLDLIQALRW TSENIGFFGG DPLRITVFGS GAGGSCVNLL TLSHYSEGNR WSNSTKGLFQ RAIAQSGTAL SSWAVSFQPA KYARILATKV GCNVSDTVEL VECLQKKPYK ELVDQDVQPA RYHIAFGPVI DGDVIPDDPQ ILMEQGEFLN YDIMLGVNQG EGLKFVENIV DSDDGVSASD FDFAVSNFVD NLYGYPEGKD VLRETIKFMY TDWADRHNPE TRRKTLLALF TDHQWVAPAV ATADLHSNFG SPTYFYAFYH HCQTDQVPAW ADAAHGDEVP YVLGIPMIGP TELFPCNFSK NDVMLSAVVM TYWTNFAKTG DPNQPVPQDT KFIHTKPNRF EEVAWTRYSQ KDQLYLHIGL KPRVKEHYRA NKVNLWLELV PHLHNLNDIS QYTSTTTKVP STDITLRPTR KNSTPVTSAF PTAKQDDPKQ QPSPFSVDQR DYSTELS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
92,026 Da
Sequence Positions
46-697
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q62765
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Nlgn1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nlgn1 purchase

MBS1471251 is a recombinant protein targeting Nlgn1. Also known as Recombinant Rat Neuroligin-1 (Nlgn1), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Nlgn1. It may not necessarily be applicable to this product.

NCBI GI #
16758736
NCBI GeneID
116647
NCBI Accession #
NP_446320.1
UniProt Primary Accession #
Q62765
UniProt Related Accession #
Q62765
GenBank Nucleotide #
NM_053868.2
NCBI Official Full Name
neuroligin-1
NCBI Official Synonym Full Names
neuroligin 1
NCBI Official Symbol
Nlgn1
UniProt Protein Name
Neuroligin-1
UniProt Synonym Protein Names
Neuroligin I
Protein Family
Neuroligin
UniProt Gene Name
Nlgn1
NCBI Protein Information
neuroligin-1

NCBI Summary for Nlgn1

transmembrane ligand for neurexins; involved in development and maturation of synaptic connections [RGD, Feb 2006]

UniProt Comments for Nlgn1

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep ().
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Research Articles on Nlgn1

1. We concluded that NLGN1 gene and protein expression is higher in the motor frontal cortex, hippocampus and in the prefrontal cortex in the forced swimming animal model of depression in WKy rats

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Nlgn1 recombinant protein

 Reference Product  PubMed Publications
 Nrxn1 recombinant protein  >10 publications with Nlgn1 and Nrxn1
 Nrxn3 recombinant protein  >3 publications with Nlgn1 and Nrxn3
 Nrxn2 recombinant protein  >2 publications with Nlgn1 and Nrxn2
 Dlg4 recombinant protein  >2 publications with Nlgn1 and Dlg4
 Shank3 recombinant protein  >1 publications with Nlgn1 and Shank3

Pathways associated with Nlgn1 recombinant protein

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Serotonin And Anxiety Pathway antibodies  Serotonin And Anxiety Pathway Diagram

Diseases associated with Nlgn1 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with Nlgn1 and Nervous System Diseases
 Brain Diseases Antibodies  >5 publications with Nlgn1 and Brain Diseases
 Autistic Disorder Antibodies  >5 publications with Nlgn1 and Autistic Disorder
 Neurobehavioral Manifestations Antibodies  >3 publications with Nlgn1 and Neurobehavioral Manifestations
 Learning Disorders Antibodies  >2 publications with Nlgn1 and Learning Disorders
 Congenital Abnormalities Antibodies  >2 publications with Nlgn1 and Congenital Abnormalities
 Abnormalities, Multiple Antibodies  >1 publications with Nlgn1 and Abnormalities, Multiple
 Neoplasm Metastasis Antibodies  >1 publications with Nlgn1 and Neoplasm Metastasis
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with Nlgn1 and Prenatal Exposure Delayed Effects
 Recurrence Antibodies  >1 publications with Nlgn1 and Recurrence

Organs/Tissues associated with Nlgn1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with Nlgn1 and Brain
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