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Succinyl-Coa Ligase [ADP-Forming] Subunit Beta, Mitochondrial (SUCLA2) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1471457

Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. This protein is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha… More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial (SUCLA2), Recombinant Protein
Full Product Name
Recombinant Human Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial (SUCLA2)
Product Gene Name
SUCLA2 recombinant protein
Product Synonym Gene Name
SUCLA2
Sequence
LSLHEYMSME LLQEAGVSVP KGYVAKSPDE AYAIAKKLGS KDVVIKAQVL AGGRGKGTFE SGLKGGVKIV FSPEEAKAVS SQMIGKKLFT KQTGEKGRIC NQVLVCERKY PRREYYFAIT MERSFQGPVL IGSSHGGVNI EDVAAESPEA IIKEPIDIEE GIKKEQALQL AQKMGFPPNI VESAAENMVK LYSLFLKYDA TMIEINPMVE DSDGAVLCMD AKINFDSNSA YRQKKIFDLQ DWTQEDERDK DAAKANLNYI GLDGNIGCLV NGAGLAMATM DIIKLHGGTP ANFLDVGGGA TVHQVTEAFK LITSDKKVLA ILVNIFGGIM RCDVIAQGIV MAVKDLEIKI PVVVRLQGTR VDDAKALIAD SGLKILACDD LDEAARMVVK LSEIVTLAKQ AHVDVKFQLP I
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
48,040 Da
Sequence Positions
53-463aa; Full-Length of the Mature Protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
603921
3D Structure
ModBase 3D Structure for Q9P2R7
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SUCLA2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SUCLA2 purchase

MBS1471457 is a recombinant protein targeting SUCLA2. Also known as Recombinant Human Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial (SUCLA2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for SUCLA2. It may not necessarily be applicable to this product.

NCBI GI #
11321583
NCBI GeneID
8803
NCBI Accession #
NP_003841.1
UniProt Primary Accession #
Q9P2R7
UniProt Secondary Accession #
O95194; Q5T9Q4; Q5T9Q6; Q9NV21; Q9NVP7; B2RDE7
UniProt Related Accession #
Q9P2R7
GenBank Nucleotide #
NM_003850.2
NCBI Official Full Name
succinate--CoA ligase
NCBI Official Synonym Full Names
succinate-CoA ligase ADP-forming beta subunit
NCBI Official Symbol
SUCLA2
NCBI Official Synonym Symbols
A-SCS; A-BETA; MTDPS5; SCS-betaA
UniProt Protein Name
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
UniProt Synonym Protein Names
ATP-specific succinyl-CoA synthetase subunit beta
UniProt Gene Name
SUCLA2
UniProt Synonym Gene Names
A-SCS; SCS-betaA
NCBI Protein Information
succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial

NCBI Summary for SUCLA2

Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]
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UniProt Comments for SUCLA2

ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:15877282). The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit ().
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Research Articles on SUCLA2

1. SUCLA2 mutation is associated with Down syndrome and mitochondrial depletion syndrome.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SUCLA2 recombinant protein

 Reference Product  PubMed Publications
 SUCLG1 recombinant protein  >16 publications with SUCLA2 and SUCLG1

Pathways associated with SUCLA2 recombinant protein

 Products by Pathway  Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway Diagram
 Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway antibodies  Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway Diagram
 Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway antibodies  Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway Diagram
 Citric Acid Cycle (TCA Cycle) Pathway antibodies  Citric Acid Cycle (TCA Cycle) Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram

Diseases associated with SUCLA2 recombinant protein

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >8 publications with SUCLA2 and Liver Diseases
 Atrophy Antibodies  >5 publications with SUCLA2 and Atrophy
 Heart Diseases Antibodies  >2 publications with SUCLA2 and Heart Diseases
 Pain Antibodies  >1 publications with SUCLA2 and Pain
 Kidney Diseases Antibodies  >1 publications with SUCLA2 and Kidney Diseases
 MITOCHONDRIAL DNA DEPLETION SYNDROME 5 (ENCEPHALOMYOPATHIC WITH OR WITHOUT METHYLMALONIC ACIDURIA) Antibodies  >1 publications with SUCLA2 and MITOCHONDRIAL DNA DEPLETION SYNDROME 5 (ENCEPHALOMYOPATHIC WITH OR WITHOUT METHYLMALONIC ACIDURIA)

Organs/Tissues associated with SUCLA2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >18 publications with SUCLA2 and Muscle
 Brain Antibodies  >15 publications with SUCLA2 and Brain
 Blood Antibodies  >9 publications with SUCLA2 and Blood
 Liver Antibodies  >7 publications with SUCLA2 and Liver
 Heart Antibodies  >2 publications with SUCLA2 and Heart
 Bone Antibodies  >1 publications with SUCLA2 and Bone
 Skin Antibodies  >1 publications with SUCLA2 and Skin
 Placenta Antibodies  >1 publications with SUCLA2 and Placenta
 Eye Antibodies  >1 publications with SUCLA2 and Eye
 Nerve Antibodies  >1 publications with SUCLA2 and Nerve
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