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Transforming Growth Factor Beta Receptor II (TGFBR2) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS147146

Description: TGFBR2 Human Recombinant produced in in Sf9 Baculoviruscells is a single, non-glycosylated polypeptide chain containing 383 aminoacids (23-166a.a) and having a molecular mass of 43.3kDa (Migrates at 40-57kDaon SDS-PAGE under reducing conditions).… More details

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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Transforming Growth Factor Beta Receptor II (TGFBR2), Recombinant Protein
Full Product Name
Recombinant Human Transforming Growth Factor Beta Receptor II, His Tag
Product Gene Name
TGFBR2 recombinant protein
Product Synonym Names
AAT3; FAA3; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; TGFBR-2; TGF-betareceptor type-2; Transforming growth factor-beta receptor type II; TGF-betareceptor type II; TGF-beta type II receptor; TbetaR-II; TGFBR2; TGFBR2 Human, His; Transforming Growth Factor Beta Receptor II, His Tag Human Recombinant
Sequence
TIPPHVQKSV NNDMIVTDNN GAVKFPQLCK FCDVRFSTCD NQKSCMSNCS ITSICEKPQE VCVAVWRKND ENITLETVCH DPKLPYHDFI LEDAASPKCI MKEKKKPGET FFMCSCSSDE CNDNIIFSEE YNTSNPDLLL VIFQLEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSRDELTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGKHHH HHH.
Host
Sf9, Baculovirus cells
Form/Format
Sterile filtered colorless solution
Solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol
Purity/Purification
Greater than 95% as determined by SDS-PAGE
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at-20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles
Molecular Weight
67,457 Da
OMIM
M85079 mRNA
3D Structure
ModBase 3D Structure for P37173

Product Categories/Family for TGFBR2 recombinant protein

Protein Kinases; Enzymes; Protein Kinases; TGFBR2 Human; His

Other Notes

Small volumes of TGFBR2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TGFBR2 purchase

MBS147146 is a recombinant protein targeting TGFBR2. Also known as Recombinant Human Transforming Growth Factor Beta Receptor II, His Tag. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for TGFBR2. It may not necessarily be applicable to this product.

NCBI GI #
116242818
NCBI GeneID
7048
NCBI Accession #
P37173.2
UniProt Primary Accession #
P37173
UniProt Secondary Accession #
Q15580; Q6DKT6; Q99474; B4DTV5
UniProt Related Accession #
P37173
NCBI Official Full Name
TGF-beta receptor type-2
NCBI Official Synonym Full Names
transforming growth factor beta receptor 2
NCBI Official Symbol
TGFBR2
NCBI Official Synonym Symbols
AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TBRII; TBR-ii; TGFR-2; TGFbeta-RII
UniProt Protein Name
TGF-beta receptor type-2
UniProt Synonym Protein Names
TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II
Protein Family
TGF-beta receptor
UniProt Gene Name
TGFBR2
UniProt Synonym Gene Names
TGFR-2; TGF-beta receptor type II; TbetaR-II
NCBI Protein Information
TGF-beta receptor type-2

NCBI Summary for TGFBR2

The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]
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UniProt Comments for TGFBR2

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
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Research Articles on TGFBR2

1. MiR-130 is up-regulated in gastric cancer (GC) tissues and directly targets TGF-beta type II receptor (TGFbetaR2).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TGFBR2 recombinant protein

 Reference Product  PubMed Publications
 TGFBR1 recombinant protein  >125 publications with TGFBR2 and TGFBR1
 TGFB1 recombinant protein  >67 publications with TGFBR2 and TGFB1
 SMAD2 recombinant protein  >33 publications with TGFBR2 and SMAD2
 TGFB2 recombinant protein  >28 publications with TGFBR2 and TGFB2
 SMAD4 recombinant protein  >25 publications with TGFBR2 and SMAD4
 CTNNB1 recombinant protein  >15 publications with TGFBR2 and CTNNB1
 TGFBR3 recombinant protein  >13 publications with TGFBR2 and TGFBR3
 SMAD7 recombinant protein  >12 publications with TGFBR2 and SMAD7
 TGFB3 recombinant protein  >10 publications with TGFBR2 and TGFB3
 ACVRL1 recombinant protein  >8 publications with TGFBR2 and ACVRL1

Pathways associated with TGFBR2 recombinant protein

 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with TGFBR2 recombinant protein

 Disease Name  Pubmed Publications
 Marfan Syndrome Antibodies  >81 publications with TGFBR2 and Marfan Syndrome
 Aortic Aneurysm Antibodies  >80 publications with TGFBR2 and Aortic Aneurysm
 Loeys-Dietz Syndrome Antibodies  >71 publications with TGFBR2 and Loeys-Dietz Syndrome
 Heart Diseases Antibodies  >68 publications with TGFBR2 and Heart Diseases
 Carcinoma Antibodies  >68 publications with TGFBR2 and Carcinoma
 Bone Diseases Antibodies  >64 publications with TGFBR2 and Bone Diseases
 Craniofacial Abnormalities Antibodies  >52 publications with TGFBR2 and Craniofacial Abnormalities
 Aneurysm, Dissecting Antibodies  >45 publications with TGFBR2 and Aneurysm, Dissecting
 Aortic Aneurysm, Thoracic Antibodies  >44 publications with TGFBR2 and Aortic Aneurysm, Thoracic
 Microsatellite Instability Antibodies  >43 publications with TGFBR2 and Microsatellite Instability

Organs/Tissues associated with TGFBR2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >2 publications with TGFBR2 and Placenta
 Uncharacterized Tissue Antibodies  >1 publications with TGFBR2 and Uncharacterized Tissue
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