• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Nuclear Receptor Coactivator 3 (NCOA3) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1471558

This protein is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300CBP-associated factor and CREB… More details

$870 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Nuclear receptor coactivator 3 (NCOA3), Recombinant Protein
Full Product Name
Recombinant Human Nuclear receptor coactivator 3 (NCOA3) , partial
Product Gene Name
NCOA3 recombinant protein
Product Synonym Gene Name
NCOA3
Sequence
FQGQEAAVMM DQKAGLYGQT YPAQGPPMQG GFHLQGQSPS FNSMMNQMNQ QGNFPLQGMH PRANIMRPRT NTPKQLRMQL QQRLQGQQFL NQSRQALELK MENPTAGGAA VMRPMMQPQV SSQQGFLNAQ MVAQRSRELL SHHFRQQRVA MMMQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQTQAFSPPP NVTASPSMDG LLAGPTMPQA PP
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
154,892 Da
Sequence Positions
1095-1306a; Partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
601937
3D Structure
ModBase 3D Structure for Q9Y6Q9
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NCOA3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NCOA3 purchase

MBS1471558 is a recombinant protein targeting NCOA3. Also known as Recombinant Human Nuclear receptor coactivator 3 (NCOA3) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for NCOA3. It may not necessarily be applicable to this product.

NCBI GI #
291490685
NCBI GeneID
8202
NCBI Accession #
NP_001167559.1
UniProt Primary Accession #
Q9Y6Q9
UniProt Secondary Accession #
Q0VF45; Q5JYD9; Q5JYE0; Q9BR49; Q9UPC9; Q9UPG4; Q9UPG7; A4LAZ5
UniProt Related Accession #
Q9Y6Q9
GenBank Nucleotide #
NM_001174088.1
NCBI Official Full Name
nuclear receptor coactivator 3 isoform d
NCBI Official Synonym Full Names
nuclear receptor coactivator 3
NCBI Official Symbol
NCOA3
NCBI Official Synonym Symbols
ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42
UniProt Protein Name
Nuclear receptor coactivator 3
UniProt Synonym Protein Names
ACTR; Amplified in breast cancer 1 protein; AIB-1; CBP-interacting protein; pCIP; Class E basic helix-loop-helix protein 42; bHLHe42; Receptor-associated coactivator 3; RAC-3; Steroid receptor coactivator protein 3; SRC-3; Thyroid hormone receptor activator molecule 1; TRAM-1
Protein Family
Nuclear receptor coactivator
UniProt Gene Name
NCOA3
UniProt Synonym Gene Names
AIB1; BHLHE42; RAC3; TRAM1; NCoA-3; AIB-1; pCIP; bHLHe42; RAC-3; SRC-3; TRAM-1
NCBI Protein Information
nuclear receptor coactivator 3

NCBI Summary for NCOA3

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]
Show more

UniProt Comments for NCOA3

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
Show more

Research Articles on NCOA3

1. The model had 92% sensitivity and 92% specificity. We obtained similar results in the independent validation cohort. AIB1 and EIF5A2 show promise for the noninvasive detection of bladder cancer. The model based on AIB1, EIF5A2, and NMP22 outperformed each of the three individual biomarkers for detecting Bladder cancer.
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NCOA3 recombinant protein

 Reference Product  PubMed Publications
 CREBBP recombinant protein  >19 publications with NCOA3 and CREBBP
 ERBB2 recombinant protein  >12 publications with NCOA3 and ERBB2
 CCND1 recombinant protein  >11 publications with NCOA3 and CCND1
 CARM1 recombinant protein  >10 publications with NCOA3 and CARM1
 VDR recombinant protein  >8 publications with NCOA3 and VDR
 MYC recombinant protein  >7 publications with NCOA3 and MYC
 NCOR2 recombinant protein  >7 publications with NCOA3 and NCOR2
 E2F1 recombinant protein  >5 publications with NCOA3 and E2F1
 PPARG recombinant protein  >5 publications with NCOA3 and PPARG
 EP300 recombinant protein  >5 publications with NCOA3 and EP300

Pathways associated with NCOA3 recombinant protein

 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram
 Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies  Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
 Retinoic Acid Receptors-mediated Signaling Pathway antibodies  Retinoic Acid Receptors-mediated Signaling Pathway Diagram

Diseases associated with NCOA3 recombinant protein

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >127 publications with NCOA3 and Breast Neoplasms
 Adenocarcinoma Antibodies  >28 publications with NCOA3 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >19 publications with NCOA3 and Neoplasms, Experimental
 Prostatic Neoplasms Antibodies  >16 publications with NCOA3 and Prostatic Neoplasms
 Disease Models, Animal Antibodies  >13 publications with NCOA3 and Disease Models, Animal
 Ovarian Neoplasms Antibodies  >12 publications with NCOA3 and Ovarian Neoplasms
 Hyperplasia Antibodies  >11 publications with NCOA3 and Hyperplasia
 Liver Neoplasms Antibodies  >11 publications with NCOA3 and Liver Neoplasms
 Inflammation Antibodies  >10 publications with NCOA3 and Inflammation
 Liver Diseases Antibodies  >10 publications with NCOA3 and Liver Diseases

Organs/Tissues associated with NCOA3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >30 publications with NCOA3 and Blood
 Liver Antibodies  >29 publications with NCOA3 and Liver
 Prostate Antibodies  >28 publications with NCOA3 and Prostate
 Thyroid Antibodies  >21 publications with NCOA3 and Thyroid
 Lymph Antibodies  >19 publications with NCOA3 and Lymph
 Lymph Node Antibodies  >19 publications with NCOA3 and Lymph Node
 Lung Antibodies  >17 publications with NCOA3 and Lung
 Uterus Antibodies  >17 publications with NCOA3 and Uterus
 Brain Antibodies  >16 publications with NCOA3 and Brain
 Muscle Antibodies  >16 publications with NCOA3 and Muscle
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000