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TRAF-Interacting Protein (TRAIP) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1471621

This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with… More details

$1250 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TRAF-interacting protein (Traip), Recombinant Protein
Full Product Name
Recombinant Mouse TRAF-interacting protein (Traip)
Product Gene Name
Traip recombinant protein
Product Synonym Gene Name
Traip
Sequence
MPIRALCTIC SDFFDHSRDV AAIHCGHTFH LQCLIQWFET APSRTCPQCR IQVGKKTIIN KLFFDLAQEE ENVLDAEFLK NELDSVKAQL SQKDREKRDS QAIIDTLRDT LEERNATVES LQNALNKAEM LCSTLKKQMK FLEQRQDETK QAREEAHRLK CKMKTMEQIE LLLQSQRSEV EEMIRDMGVG QSAVEQLAVY CVSLKKEYEN LKEARKATGE LADRLKKDLV SSRSKLKTLN TELDQAKLEL RSAQKDLQSA DQEITSLRKK LMILQGTLSL PPATNETVSR LVFESPAPVE MMNPRLHQPP FGDEIDLNTT FDVNTPPTQT SGSQHCLPKK LCLERARSPM QNVLKKVHKV SKPESQLSLG GQRCVGELDE ELAGAFPLFI RNAVLGQKQP NRTTAESRCS TDVVRIGFDG LGGRTKFIQP RDTTIIRPVP VKSKAKSKQK VRIKTVSSAS QPKLDTFLCQ
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
25,585 Da
Sequence Positions
1-470, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q8VIG6
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Traip recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Traip purchase

MBS1471621 is a recombinant protein targeting Traip. Also known as Recombinant Mouse TRAF-interacting protein (Traip). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Traip. It may not necessarily be applicable to this product.

NCBI GI #
31560535
NCBI GeneID
22036
NCBI Accession #
NP_035764.2
UniProt Primary Accession #
Q8VIG6
UniProt Secondary Accession #
O08854; Q922M8; Q9CPP4
UniProt Related Accession #
Q8VIG6
GenBank Nucleotide #
NM_011634.3
NCBI Official Full Name
E3 ubiquitin-protein ligase TRAIP
NCBI Official Synonym Full Names
TRAF-interacting protein
NCBI Official Symbol
Traip
NCBI Official Synonym Symbols
Trip
UniProt Protein Name
E3 ubiquitin-protein ligase TRAIP
UniProt Synonym Protein Names
RING-type E3 ubiquitin transferase TRAIPCurated; TRAF-interacting protein
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
Traip
UniProt Synonym Gene Names
Trip
NCBI Protein Information
E3 ubiquitin-protein ligase TRAIP

UniProt Comments for Traip

E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation () (PubMed:17544371, PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase. Might also play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity. The function in translesion synthesis is controversial ().
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Research Articles on Traip

1. TRIP as a negative regulator in TLR3/4- and RIG-I-triggered antiviral responses and suggested TRIP as a potential target for the intervention of diseases with uncontrolled IFN-beta production.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Traip recombinant protein

 Products by Pathway  Pathway Diagram
 TNF-alpha NF-kB Signaling Pathway antibodies  TNF-alpha NF-kB Signaling Pathway Diagram

Diseases associated with Traip recombinant protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >3 publications with Traip and Necrosis
 Neoplasms Antibodies  >1 publications with Traip and Neoplasms
 Skin Neoplasms Antibodies  >1 publications with Traip and Skin Neoplasms

Organs/Tissues associated with Traip recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >1 publications with Traip and Skin
 Brain Antibodies  >1 publications with Traip and Brain
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